INT67352

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.55
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
mesangial cells 2
body 2
spinal cord 1
hippocampus 1
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 12 99.74 Very High Very High Very High
Hippocampus 12 99.28 Very High Very High Very High
Spinal cord 12 98.64 Very High Very High Very High
opiate 4 97.08 Very High Very High Very High
anesthesia 2 91.60 High High
Clonidine 2 48.88 Quite Low
Somatostatin 44 45.76 Quite Low
Dopamine 18 43.52 Quite Low
agonist 16 42.80 Quite Low
antagonist 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 16 95.64 Very High Very High Very High
Cancer 24 81.24 Quite High
Breast Cancer 2 76.48 Quite High
Weight Loss 1 67.76 Quite High
Meningioma 2 66.04 Quite High
Hypertrophy 4 54.40 Quite High
Acromegaly 54 50.00 Quite Low
Disease 14 49.20 Quite Low
Injury 1 42.92 Quite Low
Sepsis 1 42.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The circulating high affinity GH-binding protein (GHBP), which derives from the extracellular domain of the hepatic GH receptor, correlates inversely to GH levels and directly to body mass index (BMI) in healthy adults.
Transcription (derives) of GHBP in body associated with obesity
1) Confidence 0.61 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.32 Pain Relevance 0
The circulating high affinity GH-binding protein (GHBP), which derives from the extracellular domain of the hepatic GH receptor, correlates inversely to GH levels and directly to body mass index (BMI) in healthy adults.
Transcription (derives) of GH-binding protein in body associated with obesity
2) Confidence 0.61 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.32 Pain Relevance 0
Growth hormone, both the 20 kDa and the 22 kDa isoforms, amplify GHR and GHBP gene transcription in human mesangial cells in vitro and this effect was blocked specifically by pegvisomant (Meinhardt et al 2003).
Transcription (transcription) of GHBP gene in mesangial cells
3) Confidence 0.54 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.42 Pain Relevance 0
Growth hormone, both the 20 kDa and the 22 kDa isoforms, amplify GHR and GHBP gene transcription in human mesangial cells in vitro and this effect was blocked specifically by pegvisomant (Meinhardt et al 2003).
Transcription (transcription) of GHR in mesangial cells
4) Confidence 0.54 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.42 Pain Relevance 0
Northern blot analysis showed that in both tissues the levels of the transcripts for both GHR and GHBP were significantly decreased 4 h after a single dose of morphine.
Transcription (transcripts) of GHBP associated with morphine
5) Confidence 0.24 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.59
In this study we have characterized the nucleotide sequence of the cDNA for the growth hormone receptor (GHR) and examined the effects of morphine on the gene transcripts for GHR as well as GH binding protein (GHBP) in the male rat hippocampus and spinal cord.
Transcription (transcripts) of GHBP in spinal cord associated with hippocampus, spinal cord and morphine
6) Confidence 0.18 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.49
This result indicates that the opiate does not only affect the receptor protein as shown earlier by binding studies, but also reduces the expression or turnover of the GHR as well as GHBP at the transcription level.
Transcription (transcription) of GHBP associated with opiate
7) Confidence 0.18 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.55
IGF-I mRNA and GHR mRNA levels were related to the expression of a housekeeping gene (cyclophilin).
Transcription (levels) of GHR
8) Confidence 0.08 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9589657 Disease Relevance 0.07 Pain Relevance 0.18
In this study we have characterized the nucleotide sequence of the cDNA for the growth hormone receptor (GHR) and examined the effects of morphine on the gene transcripts for GHR as well as GH binding protein (GHBP) in the male rat hippocampus and spinal cord.
Transcription (transcripts) of GHBP in hippocampus associated with hippocampus, spinal cord and morphine
9) Confidence 0.06 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.49

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