INT67368

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.08
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tph1)
Anatomy Link Frequency
trigeminal ganglia 1
Tph1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1 95.68 Very High Very High Very High
Migraine 1 84.16 Quite High
headache 1 83.44 Quite High
Serotonin 7 81.76 Quite High
spastic colon 2 50.00 Quite Low
menstrual migraine 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Migraine Disorders 1 84.16 Quite High
Functional Bowel Disorder 2 50.00 Quite Low
Inflammatory Bowel Disease 2 50.00 Quite Low
Menstral Migraine 1 50.00 Quite Low
Nociception 1 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, their use for studies on the glucocorticoid regulation of the TPH gene will be discussed.
Regulation (regulation) of TPH gene
1) Confidence 0.62 Published 1996 Journal Mol. Neurobiol. Section Abstract Doc Link 8989773 Disease Relevance 0.08 Pain Relevance 0.29
It is not known whether serotonin, its rate-limiting enzyme tryptophan hydroxylase (TPH), or its receptors are regulated by ovarian steroids in trigeminal ganglia.
Spec (whether) Regulation (regulated) of TPH in trigeminal ganglia
2) Confidence 0.60 Published 2006 Journal Headache Section Body Doc Link 16942467 Disease Relevance 0 Pain Relevance 0
RESULTS: Mucosal 5-HT, tryptophan hydroxylase 1 messenger RNA, serotonin transporter messenger RNA, and serotonin transporter immunoreactivity were all significantly reduced in UC, IBS-C, and IBS-D.
Regulation (immunoreactivity) of tryptophan hydroxylase 1 messenger RNA
3) Confidence 0.01 Published 2004 Journal Gastroenterology Section Body Doc Link 15188158 Disease Relevance 0 Pain Relevance 0

General Comments

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