INT67373

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Context Info
Confidence 0.39
First Reported 1996
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 6.28
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mefv) nucleus (Mefv) intracellular (Mefv)
cytoplasm (Mefv)
Mefv (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 246 99.84 Very High Very High Very High
Inflammation 60 81.40 Quite High
Pain 1 63.08 Quite High
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 52 100.00 Very High Very High Very High
Inflammatory Bowel Disease 357 99.84 Very High Very High Very High
Disease 289 99.84 Very High Very High Very High
Colitis 24 98.76 Very High Very High Very High
Amyloidosis 3 87.84 High High
INFLAMMATION 51 81.40 Quite High
Myalgia 1 76.20 Quite High
Apoptosis 3 66.68 Quite High
Injury 3 65.16 Quite High
Serositis 1 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although these mutations are found throughout the gene, five sequence alterations in MEFV represent the majority of FMF chromosomes, four of which are clustered in exon 10 (i.e.
Regulation (majority) of Gene_expression (chromosomes) of FMF associated with fever
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.50 Pain Relevance 0.25
MEFV mutations in exon 10 do not contribute to CD and UC susceptibility
Neg (not) Regulation (contribute) of Gene_expression (mutations) of MEFV associated with inflammatory bowel disease and crohn's disease
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.67 Pain Relevance 0.27
We therefore explored whether MEFV expression was regulated in IBD experimental models of colitis and whether MEFV variants were associated with CD and/or UC susceptibility.


Spec (whether) Regulation (regulated) of Spec (whether) Gene_expression (expression) of MEFV associated with colitis, inflammatory bowel disease and crohn's disease
3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.91 Pain Relevance 0.17
The most important achievement in recent years, however, is the mapping of the FMF susceptibility gene to chromosome 16p, a finding that raises hopes for prompt cloning of the gene and elucidation of the mechanisms involved in FMF expression.
Regulation (involved) of Gene_expression (expression) of FMF associated with fever
4) Confidence 0.17 Published 1996 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 8989806 Disease Relevance 1.20 Pain Relevance 0.06

General Comments

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