INT67397

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 11.36
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 3
blood 2
lymph nodes 1
lymphoid tissue 1
skin 1
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 171 100.00 Very High Very High Very High
Inflammation 83 100.00 Very High Very High Very High
Neuritis 36 99.66 Very High Very High Very High
Sciatic nerve 4 96.20 Very High Very High Very High
diclofenac 11 93.76 High High
Peripheral nervous system 2 88.44 High High
anticonvulsant 2 86.32 High High
Paracetamol 2 77.76 Quite High
cINOD 5 75.00 Quite High
peptic ulcer disease 1 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 87 100.00 Very High Very High Very High
Cancer 12 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 36 99.66 Very High Very High Very High
Immunization 3 99.38 Very High Very High Very High
Acrodermatitis 5 99.10 Very High Very High Very High
Gastritis 17 98.66 Very High Very High Very High
Erythema 6 98.22 Very High Very High Very High
Disease Susceptibility 1 95.88 Very High Very High Very High
Hepatotoxicity 8 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the observed polymorphisms, resulting in low IL-10 and high IL-4 gene transcription, could favor a T helper (Th)-2 mediated antibody response to neoantigenic stimulation associated with disease susceptibility.
Transcription (transcription) of IL-4 associated with disease susceptibility
1) Confidence 0.54 Published 2004 Journal Hepatology Section Abstract Doc Link 15122773 Disease Relevance 0.67 Pain Relevance 0.36
In order to further analyze the role of these T cells and their corresponding cytokines in EAN, we studied the expression of mRNA for IFN-gamma, IL-4, and IL-10 in the cauda equina of rats with EAN using a quantitative competitive reverse transcriptase PCR method.
Transcription (expression) of IL-4 in T cells associated with neuritis and cytokine
2) Confidence 0.50 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9628467 Disease Relevance 1.05 Pain Relevance 0.60
Increased mRNA expression for IFN-gamma and TNF-alpha was registered correlating with the peak of clinical signs of EAN, and high levels of mRNA expression for IL-4, IL-10, and TGF-beta were associated with EAN recovery.
Transcription (expression) of IL-4 associated with neuritis
3) Confidence 0.28 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.09 Pain Relevance 1.14
VPA (300 mg/kg, intraperitoneally) administration to EAN rats once daily immediately following immunization significantly suppressed mRNA levels of interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-4, IL-6 and IL-17 in the lymph nodes of EAN rats.
Transcription (levels) of IL-4 in lymph nodes associated with necrosis, cancer, immunization and neuritis
4) Confidence 0.26 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18953683 Disease Relevance 1.37 Pain Relevance 1.01
Splenic T cells were isolated and the production and mRNA expression of interleukin (IL)-2, interferon-gamma, IL-4, and IL-10 were assayed.
Transcription (expression) of IL-4 in T cells
5) Confidence 0.23 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
To study the potential role of cytokines in context with cytokine autoantibodies (Aabs) in EAN, we used in situ hybridization to detect mRNA expression of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-4, IL-10, and transforming growth factor (TGF)-beta in lymph node mononuclear cell (MNC) and in sciatic nerve sections, as well as ELISA for detection of their autoantibodies in sera and cerebrospinal fluid (CSF) over the course of EAN.
Transcription (expression) of IL-4 in mononuclear cell associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
6) Confidence 0.21 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.13 Pain Relevance 1.01
Th1 cytokine (IL-2 and interferon-gamma) production and mRNA expression in splenic T cells of traumatized rats were significantly decreased on postoperative day 3 (P < 0.001, trauma group versus control group), whereas Th2 cytokine (IL-4 and IL-10) production and mRNA expression were increased (P < 0.001).
Transcription (expression) of IL-4 in T cells
7) Confidence 0.20 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
/IL-4 at 12 and 24 hours after ERCP were found
Transcription (/) of IL-4
8) Confidence 0.11 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.32 Pain Relevance 0
Interestingly, no difference was observed in the IL-4 and INF-?
Neg (no) Transcription (observed) of IL-4
9) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2909993 Disease Relevance 0.49 Pain Relevance 0.21
Antral biopsies from all Hp-infected patients showed IFN-gamma, TNF-alpha, and IL-12, but not IL-4, mRNA expression, whereas no cytokine mRNA signal was found in the mucosa of controls.
Transcription (expression) of IL-4 associated with gastritis and cytokine
10) Confidence 0.06 Published 1997 Journal J. Immunol. Section Abstract Doc Link 8993017 Disease Relevance 1.69 Pain Relevance 0.29
Results showed expression of interferon-gamma, interleukin-6, interleukin-10, interleukin-12 p40, and tumor necrosis factor-alpha in all patients tested at the onset of reactional episodes, but interleukin-4 mRNA was rarely detected in the lesions (n = 4).
Transcription (detected) of interleukin-4 associated with necrosis and cancer
11) Confidence 0.02 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 11121122 Disease Relevance 0.89 Pain Relevance 0.28
IL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Transcription (expression) of IL-4 in blood
12) Confidence 0.02 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.36 Pain Relevance 0.23
IL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Transcription (levels) of IL-4 in blood
13) Confidence 0.02 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.36 Pain Relevance 0.23
In an effort to understand pathogenic factors that lead to different outcomes in dermatoborrelioses, skin biopsy samples from 42 patients with erythema migrans and 27 patients with acrodermatitis chronica atrophicans were analyzed for mRNA expression of five pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1 beta, interleukin-6, interferon-gamma, and interleukin-2) and two anti-inflammatory cytokines (interleukin-4 and interleukin-10) by in situ hybridization with cytokine-specific riboprobes.
Transcription (expression) of interleukin-4 in skin associated with necrosis, erythema, inflammation, cancer, acrodermatitis and cytokine
14) Confidence 0.01 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 11121150 Disease Relevance 1.82 Pain Relevance 0.60
PN is associated with a rapid fall in lymphocyte cell counts and a change in cell profiles in gut-associated lymphoid tissue; this profile change is related to decreased levels of the Th2 cytokines IL-4 and IL-10 [23].
Transcription (levels) of Th2 cytokines IL-4 in lymphoid tissue associated with cytokine
15) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.12 Pain Relevance 0.11

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