INT67399

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Context Info
Confidence 0.03
First Reported 1997
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.63
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
mononuclear cells 2
Il12a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 13 99.48 Very High Very High Very High
Neuritis 10 95.08 Very High Very High Very High
Inflammation 3 77.52 Quite High
peptic ulcer disease 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Necrosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Gastritis 17 99.62 Very High Very High Very High
Alagille Syndrome 1 96.40 Very High Very High Very High
Optic Neuritis 10 95.08 Very High Very High Very High
Duodenal Ulcer 1 89.52 High High
Congenital Anomalies 2 85.76 High High
Infection 2 81.76 Quite High
INFLAMMATION 3 77.52 Quite High
Ulcers 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study a possible relation between cytokine profiles and presence versus absence of MS-like brain MRI lesions and CSF OB, we used in situ hybridization to examine mRNA expression of the proinflammatory interleukin-12 (IL-12), interferon-gamma, and tumor necrosis factor-alpha and the immune response downregulating IL-10, transforming growth factor-beta, and IL-4 in blood and CSF mononuclear cells (MNC) from 59 patients with untreated ON.
Negative_regulation (downregulating) of Transcription (expression) of interleukin-12 in mononuclear cells associated with necrosis, cancer, neuritis and cytokine
1) Confidence 0.03 Published 1998 Journal Neurology Section Abstract Doc Link 9443483 Disease Relevance 0.92 Pain Relevance 0.76
Antral biopsies from all Hp-infected patients showed IFN-gamma, TNF-alpha, and IL-12, but not IL-4, mRNA expression, whereas no cytokine mRNA signal was found in the mucosa of controls.
Negative_regulation (showed) of Transcription (expression) of IL-12 associated with gastritis and cytokine
2) Confidence 0.01 Published 1997 Journal J. Immunol. Section Abstract Doc Link 8993017 Disease Relevance 1.71 Pain Relevance 0.29

General Comments

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