INT67401

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 20.04
Pain Relevance 11.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 3
MNC 3
monocytes 2
accessory cells 1
Il12a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 180 100.00 Very High Very High Very High
Inflammation 169 100.00 Very High Very High Very High
Catecholamine 6 99.82 Very High Very High Very High
Hyperalgesia 4 99.82 Very High Very High Very High
spastic colon 93 99.08 Very High Very High Very High
Peripheral nervous system 9 98.98 Very High Very High Very High
Neuritis 28 98.84 Very High Very High Very High
chemokine 8 98.08 Very High Very High Very High
Neurotransmitter 3 97.92 Very High Very High Very High
Multiple sclerosis 16 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 201 100.00 Very High Very High Very High
Cancer 19 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
Hyperalgesia 4 99.82 Very High Very High Very High
Coronary Artery Disease 12 99.76 Very High Very High Very High
Disease 72 99.52 Very High Very High Very High
Infection 20 99.40 Very High Very High Very High
Eosinophilia 2 99.28 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

92 99.08 Very High Very High Very High
Gastritis 18 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-lasting gene expression by particle-mediated intramuscular transfection modified with bupivacaine: combinatorial gene therapy with IL-12 and IL-18 cDNA against rat sarcoma at a distant site.
Gene_expression (expression) of IL-12 associated with sarcoma
1) Confidence 0.55 Published 2003 Journal Cancer Gene Ther. Section Title Doc Link 12679805 Disease Relevance 0.37 Pain Relevance 0.13
Preclinical studies demonstrated the successful inhibition of IL-12 and IL-23 production by the drug.
Gene_expression (production) of IL-12
2) Confidence 0.50 Published 2007 Journal IDrugs Section Abstract Doc Link 17187316 Disease Relevance 1.07 Pain Relevance 0.41
Apilimod is a small molecule that inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases - through the prevention of nuclear translocation of c-Rel.
Gene_expression (production) of IL-12 associated with autoimmune disease and cytokine
3) Confidence 0.50 Published 2007 Journal IDrugs Section Abstract Doc Link 17187316 Disease Relevance 0.68 Pain Relevance 0.25
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Gene_expression (production) of interleukin-12 associated with inflammation, disease and cytokine
4) Confidence 0.35 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.30 Pain Relevance 0.35
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Gene_expression (production) of IL-12 associated with inflammation, disease and cytokine
5) Confidence 0.35 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.30 Pain Relevance 0.35
Leishmania major: interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats.
Gene_expression (levels) of interleukin-12 associated with hyperalgesia and infection
6) Confidence 0.32 Published 2009 Journal Exp. Parasitol. Section Title Doc Link 19061890 Disease Relevance 0.79 Pain Relevance 0.56
In this study we report a different role for IL-13 in rats infected with L. major; rIL-13 stimulates expression of pro-inflammatory cytokines and IL-12 which is a key cytokine in protective immunity against Leishmania.
Gene_expression (expression) of IL-12 associated with inflammation and cytokine
7) Confidence 0.32 Published 2009 Journal Exp. Parasitol. Section Abstract Doc Link 19061890 Disease Relevance 0.77 Pain Relevance 0.56
In addition, adherent cells (monocytes/macrophages) will be stimulated for 24 hours with lipopolysaccharide to induce IL-6 and IL-12 production.
Gene_expression (production) of IL-12 in macrophages
8) Confidence 0.20 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.21 Pain Relevance 0.43
Prostaglandin E2 is known to enhance the production of TH2 cytokines via inhibition of the production of IL-12 by antigen presenting cells such as monocytes [13].
Gene_expression (production) of IL-12 in monocytes associated with cytokine
9) Confidence 0.15 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.90 Pain Relevance 0.49
Also, several other pro-inflammatory (IL-2, IL-12, IL-17 and IL-18) and anti-inflammatory (IL-4 and IL-13) cytokines have been shown to be present in a lesser extent in IBS.62

2) Role of cytokines

Gene_expression (present) of IL-12 associated with inflammation, spastic colon and cytokine
10) Confidence 0.14 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.47 Pain Relevance 1.04
Three patterns of cytokine mRNA expressing MNC in relation to clinical EAN could be distinguished: (i) IL-1beta mRNA expressing cells peaked already on day 3 post immunization (p.i.), and BPM- and P2-reactive TNF-alpha, and BPM-reactive IL-6 mRNA expressing cells were also detected already on day 7 p.i., i.e., before onset of clinical EAN; (ii) BPM- and P2-reactive TNF-alpha peaked together with P2-reactive TNF-beta, IL-6 and IL-12 mRNA expressing cells at height of clinical EAN, consistent with a disease-promoting role for these four cytokines; (iii) high levels of BPM- and P2-reactive IL-10 and cytolysin mRNA expressing cells were observed only during recovery (day 28 p.i.), consistent with a disease down-regulating role of IL-10 and cytolysin.
Gene_expression (expressing) of IL-12 mRNA in MNC associated with immunization, disease, neuritis and cytokine
11) Confidence 0.13 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9307234 Disease Relevance 1.15 Pain Relevance 0.99
To study the involvement of immunoregulatory cytokines, we induced EAN in Lewis rats by immunizing with bovine PNS myelin (BPM) and Freund's complete adjuvant. mRNA expression of the cytokines IL-1beta, IL-6, IL-10, IL-12, TNF-alpha and TNF-beta, and the cytolytic effector molecule cytolysin was examined in lymph node mononuclear cells (MNC) over the course of EAN by in situ hybridization after culture without antigen and in the presence of BPM, the myelin P2 protein, the control antigen acetylcholine receptor, or the mitogen PHA.
Gene_expression (expression) of IL-12 in MNC associated with peripheral nervous system, neuritis and cytokine
12) Confidence 0.13 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9307234 Disease Relevance 0.92 Pain Relevance 0.88
Endomorphin-2 modulates productions of TNF-alpha, IL-1beta, IL-10, and IL-12, and alters functions related to innate immune of macrophages.
Gene_expression (productions) of IL-12 in macrophages associated with cytokine
13) Confidence 0.10 Published 2002 Journal Inflammation Section Title Doc Link 12238565 Disease Relevance 0.26 Pain Relevance 0.37
inhibition, and although it was convincingly demonstrated that GK inhibit the production of IL-12, necessary for Th1 differentiation [12,24], it is tempting to speculate that additional influence through modulation of expression of molecules in accessory cells have minor contribution, if any.
Gene_expression (production) of IL-12 in accessory cells
14) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.09
Similarly, endomorphin-1 suppressed IL-10 and IL-12 productions in response to LPS.
Gene_expression (productions) of IL-12
15) Confidence 0.10 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12349950 Disease Relevance 0.17 Pain Relevance 0.27
Interleukin (IL)1beta, IL8, IL12A, IL18, TNFalpha, IFNgamma, IL4, IL6 and IL10 expression levels were analysed by real-time RT-PCR.
Gene_expression (expression) of IL12A
16) Confidence 0.09 Published 2008 Journal Scand. J. Immunol. Section Abstract Doc Link 18028289 Disease Relevance 1.16 Pain Relevance 0.39
Endomorphin-2 inhibited TNF-alpha, IL-10, and IL-12 productions, but potentiated IL-1beta production by macrophages.
Gene_expression (productions) of IL-12 in macrophages
17) Confidence 0.08 Published 2002 Journal Inflammation Section Abstract Doc Link 12238565 Disease Relevance 0.27 Pain Relevance 0.21
In addition, adherent cells (monocytes/macrophages) will be stimulated for 24 hours with lipopolysaccharide to induce IL-6 and IL-12 production.
Gene_expression (production) of IL-12 in monocytes
18) Confidence 0.07 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.21 Pain Relevance 0.43
The levels of IL-12 in patients having complex lesions tended to be higher than in those having simple lesions and levels of IL-10 tended to be lower in the former than the latter, but the differences were not statistically significant.
Gene_expression (levels) of IL-12
19) Confidence 0.06 Published 2005 Journal Cytokine Section Abstract Doc Link 15927856 Disease Relevance 0.63 Pain Relevance 0.39
To study a possible relation between cytokine profiles and presence versus absence of MS-like brain MRI lesions and CSF OB, we used in situ hybridization to examine mRNA expression of the proinflammatory interleukin-12 (IL-12), interferon-gamma, and tumor necrosis factor-alpha and the immune response downregulating IL-10, transforming growth factor-beta, and IL-4 in blood and CSF mononuclear cells (MNC) from 59 patients with untreated ON.
Gene_expression (expression) of interleukin-12 in mononuclear cells associated with necrosis, cancer, neuritis and cytokine
20) Confidence 0.04 Published 1998 Journal Neurology Section Abstract Doc Link 9443483 Disease Relevance 0.89 Pain Relevance 0.71

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