INT67423

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 7.40
Pain Relevance 3.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 24
chest 4
plasma 2
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diclofenac 11 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Inflammation 49 99.72 Very High Very High Very High
Angina 25 99.28 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 11 98.64 Very High Very High Very High
agonist 5 98.28 Very High Very High Very High
ischemia 3 96.60 Very High Very High Very High
lidocaine 4 95.84 Very High Very High Very High
withdrawal 14 91.08 High High
Pain 1 89.04 High High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 3 100.00 Very High Very High Very High
Angina 8 99.28 Very High Very High Very High
Acute Coronary Syndrome 15 98.76 Very High Very High Very High
Myocardial Infarction 28 97.82 Very High Very High Very High
Injury 3 97.64 Very High Very High Very High
Nicotine Addiction 10 96.96 Very High Very High Very High
Cv Unclassified Under Development 2 96.60 Very High Very High Very High
Stroke 2 95.40 Very High Very High Very High
Cv General 3 Under Development 13 95.20 Very High Very High Very High
Disease 3 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine, one of the most commonly used anesthetics, is known to inhibit platelet function, but its effect on platelet P-selectin expression and PLA remains unclear.
Regulation (effect) of Gene_expression (expression) of P-selectin in platelet
1) Confidence 0.60 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 19527965 Disease Relevance 0.55 Pain Relevance 0.26
The flow cytometer model markedly affects measurement of ex vivo whole blood platelet-bound P-selectin expression in patients with chest pain: are we comparing apples with oranges.
Regulation (affects) of Gene_expression (expression) of P-selectin in chest associated with angina
2) Confidence 0.60 Published 1999 Journal Thromb. Res. Section Title Doc Link 10554084 Disease Relevance 0.55 Pain Relevance 0.27
We investigated whether sevoflurane alters the expression of P-selectin on platelets and the formation of platelet-leukocyte conjugates.
Spec (whether) Regulation (alters) of Gene_expression (expression) of P-selectin in platelets
3) Confidence 0.60 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385361 Disease Relevance 0.19 Pain Relevance 0.44
Comparison of changes in circulating platelet-derived microparticles and platelet surface P-selectin expression after coronary stent implantation.
Regulation (changes) of Gene_expression (expression) of P-selectin in platelet associated with inflammation
4) Confidence 0.44 Published 2006 Journal Platelets Section Title Doc Link 16973503 Disease Relevance 0.27 Pain Relevance 0.18
CONCLUSION: Our findings may help to elucidate the inhibitory role of lidocaine on platelet P-selectin expression and PLA and infer possible therapeutic targets in the treatment of inflammatory diseases.
Regulation (elucidate) of Gene_expression (expression) of P-selectin in platelet
5) Confidence 0.44 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Body Doc Link 19527965 Disease Relevance 0 Pain Relevance 0
Platelet P-selectin expression did not significantly change after automated red cell exchange.
Neg (not) Regulation (change) of Gene_expression (expression) of P-selectin in Platelet
6) Confidence 0.43 Published 2007 Journal Ther Apher Dial Section Abstract Doc Link 17661830 Disease Relevance 0.21 Pain Relevance 0.09
Patients with a cardiac problem (unstable angina, congestive heart failure, acute myocardial infarction) had significantly elevated levels of soluble P-selectin (156.0 +/- 58.8 ng/mL, P =.002) and platelet-bound P-selectin (11.7% +/- 6.4% positive cells, P =.013) compared with the P-selectin profile among controls (102.6 +/- 29.0 ng/mL, 4.1% +/- 1.2% positivity) and among patients with noncardiac chest pain (114.7 +/- 36.6 ng/mL, 5.7% +/- 2.9% positivity).
Regulation (controls) of Gene_expression (profile) of P-selectin in chest
7) Confidence 0.43 Published 2000 Journal Am. Heart J. Section Body Doc Link 10650306 Disease Relevance 0.16 Pain Relevance 0
Expression of P-selectin was reduced by diclofenac and unaffected by enalapril, even when combined with diclofenac.
Neg (unaffected) Regulation (unaffected) of Gene_expression (Expression) of P-selectin associated with diclofenac
8) Confidence 0.39 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716214 Disease Relevance 0.58 Pain Relevance 0.61
Increased P-selectin activity in AMI appeared to be attenuated by direct PTCA, but augmented by thrombolysis, possibly due to direct stimulatory effects of TPA on P-selectin expression.
Regulation (effects) of Gene_expression (expression) of P-selectin associated with myocardial infarction and percutaneous transluminal coronary angioplasty
9) Confidence 0.38 Published 1998 Journal Angiology Section Abstract Doc Link 9783645 Disease Relevance 0.75 Pain Relevance 0.47
Flow-cytometric evaluation of platelet activity was performed in order to recognize GMP-140 expression on platelet membrane.
Regulation (recognize) of Gene_expression (expression) of GMP-140 in platelet
10) Confidence 0.38 Published 1999 Journal Clin Cardiol Section Body Doc Link 10486696 Disease Relevance 0 Pain Relevance 0
We evaluated the influence of the duration of cold preservation time on the expression of platelet GPIIb/IIIa and P-selectin and on the formation of leukocyte-platelet complexes after kidney transplantation.
Regulation (influence) of Gene_expression (expression) of P-selectin in platelet
11) Confidence 0.35 Published 2003 Journal Clin Transplant Section Abstract Doc Link 14703928 Disease Relevance 0.64 Pain Relevance 0.21
When stimulated with agonists, patients' platelets had significantly decreased fibrinogen binding (P < .03) but no difference in P-selectin expression compared with the age-matched group.
Neg (no) Regulation (difference) of Gene_expression (expression) of P-selectin in platelets associated with agonist
12) Confidence 0.14 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351370 Disease Relevance 0.27 Pain Relevance 0.24
CONCLUSIONS: The three main classes of antianginal medication have different and possible clinically relevant effects on platelet behavior in vivo, nitrates causing inhibition of aggregation (fibrinogen binding) and degranulation (P-selectin expression), calcium antagonists enhancing degranulation, and beta-blockers enhancing aggregation.


Regulation (degranulation) of Gene_expression (expression) of P-selectin in platelet
13) Confidence 0.12 Published 1997 Journal Circulation Section Body Doc Link 8994427 Disease Relevance 0 Pain Relevance 0
Changes in soluble P-selectin levels correlated only weakly with changes in sCD40L levels (correlation coefficient reached 0.32 at 4 weeks with P = 0.024; Fig. 2).Fig. 2Correlation between sCD40L and P-selectin levels
Regulation (Changes) of Gene_expression (levels) of P-selectin
14) Confidence 0.07 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.51 Pain Relevance 0.25
Secondary endpoints included changes from baseline in plasma soluble P-selectin and hsCRP levels.
Regulation (changes) of Gene_expression (levels) of P-selectin in plasma
15) Confidence 0.07 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.09 Pain Relevance 0.15
Our data indicate an association between increased prolactin values and enhanced P-selectin expression on platelets in patients with acute coronary syndromes.
Regulation (association) of Gene_expression (expression) of P-selectin in platelets associated with acute coronary syndrome
16) Confidence 0.06 Published 2006 Journal Horm. Metab. Res. Section Abstract Doc Link 17111306 Disease Relevance 0.91 Pain Relevance 0.16
The levels of platelet-derived microparticles (PDMPs), platelet activation markers (P-selectin, CD63, and PAC-1 on activated platelets), and C-C chemokines (monocyte chemotactic peptide [MCP]-1 and regulated on activation normally T-cell expressed and secreted [RANTES] were measured and compared in patients with acute myocardial infarction (AMI) or stable pectoris angina.
Regulation (regulated) of in platelet Gene_expression (expressed) of P-selectin in platelets associated with chemokine, heart rate under development, angina and myocardial infarction
17) Confidence 0.04 Published 2002 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 12361207 Disease Relevance 0.81 Pain Relevance 0.25
In addition, TPO levels significantly correlated with ex vivo platelet-monocyte aggregation and P-selectin expression.
Regulation (aggregation) of Gene_expression (expression) of P-selectin in platelet
18) Confidence 0.04 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 20006331 Disease Relevance 0.91 Pain Relevance 0.09

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