INT67424

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 36
Total Number 41
Disease Relevance 17.08
Pain Relevance 7.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 35
leukocyte 7
chest 4
blood 2
plaques 2
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 215 100.00 Very High Very High Very High
agonist 37 99.98 Very High Very High Very High
adenocard 8 99.74 Very High Very High Very High
lidocaine 4 99.58 Very High Very High Very High
anesthesia 5 99.32 Very High Very High Very High
Angina 63 99.20 Very High Very High Very High
aspirin 182 97.86 Very High Very High Very High
analgesia 56 97.56 Very High Very High Very High
Opioid 127 93.36 High High
cINOD 12 93.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 264 100.00 Very High Very High Very High
Acute Coronary Syndrome 67 100.00 Very High Very High Very High
Adhesions 34 100.00 Very High Very High Very High
Atherosclerotic Plaque 2 99.84 Very High Very High Very High
Diabetes Mellitus 54 99.70 Very High Very High Very High
Coronary Heart Disease 13 99.38 Very High Very High Very High
Myocardial Infarction 36 99.28 Very High Very High Very High
Sickle Cell Anemia 4 99.28 Very High Very High Very High
Cv General 3 Under Development 33 99.20 Very High Very High Very High
Syndrome 8 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been reported that platelet expression and plasma levels of soluble P-selectin are increased in patients with unstable coronary artery syndromes.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in platelet associated with vascular disease
1) Confidence 0.68 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10947910 Disease Relevance 0.48 Pain Relevance 0.23
The relative increase in PDMPs was not correlated with the increase in P-selectin expression at 15 min or 24 h after coronary stenting, but was correlated at 48 h (R = 0.48, P < 0.05).
Positive_regulation (increase) of Gene_expression (expression) of P-selectin
2) Confidence 0.68 Published 2006 Journal Platelets Section Abstract Doc Link 16973503 Disease Relevance 0.20 Pain Relevance 0.11
BACKGROUND: Activation of platelets, which plays an important role in inflammation, has recently been reported to enhance platelet P-selectin expression and form platelet-leukocyte aggregation (PLA).
Positive_regulation (enhance) of Gene_expression (expression) of P-selectin in platelets associated with inflammation
3) Confidence 0.68 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 19527965 Disease Relevance 0.53 Pain Relevance 0.25
Lidocaine priming reduces ADP-induced P-selectin expression and platelet-leukocyte aggregation.
Positive_regulation (induced) of Gene_expression (expression) of P-selectin in leukocyte associated with lidocaine
4) Confidence 0.68 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Title Doc Link 19527965 Disease Relevance 0.53 Pain Relevance 0.27
Sevoflurane anesthesia attenuates adenosine diphosphate-induced P-selectin expression and platelet-leukocyte conjugate formation.
Positive_regulation (induced) of Gene_expression (expression) of P-selectin in leukocyte associated with adenocard and anesthesia
5) Confidence 0.68 Published 2004 Journal Anesth. Analg. Section Title Doc Link 15385361 Disease Relevance 0.18 Pain Relevance 0.48
In conclusion, automated red cell exchange procedures do not induce platelet P-selectin expression in patients with sickle cell disease in the steady state or in vaso-occlusive crisis.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of P-selectin in platelet associated with sickle cell anemia
6) Confidence 0.66 Published 2007 Journal Ther Apher Dial Section Abstract Doc Link 17661830 Disease Relevance 0.23 Pain Relevance 0.06
We found that P-selectin expression was significantly increased at 1 h but not 3 h after Indo administration, whereas ICAM-1 expression was significantly increased at both 1 and 3 h after Indo treatment.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin
7) Confidence 0.63 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.57 Pain Relevance 0.34
P-selectin expression is increased in atherosclerotic plaques, and high plasma levels of this molecule have been observed in patients with unstable angina.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in plaques associated with atherosclerotic plaque and angina
8) Confidence 0.61 Published 1998 Journal Hum. Mol. Genet. Section Abstract Doc Link 9668170 Disease Relevance 0.60 Pain Relevance 0.10
Both circulating PDMPs and P-selectin expression were enhanced in association with stent-induced platelet activation; however, the time course of changes in these two platelet activation markers was different.
Positive_regulation (circulating) of Gene_expression (expression) of P-selectin in platelet
9) Confidence 0.49 Published 2006 Journal Platelets Section Abstract Doc Link 16973503 Disease Relevance 0.19 Pain Relevance 0.10
Both circulating PDMPs and P-selectin expression were enhanced in association with stent-induced platelet activation; however, the time course of changes in these two platelet activation markers was different.
Positive_regulation (enhanced) of Gene_expression (expression) of P-selectin in platelet
10) Confidence 0.49 Published 2006 Journal Platelets Section Abstract Doc Link 16973503 Disease Relevance 0.18 Pain Relevance 0.10
Patients with a cardiac problem (unstable angina, congestive heart failure, acute myocardial infarction) had significantly elevated levels of soluble P-selectin (156.0 +/- 58.8 ng/mL, P =.002) and platelet-bound P-selectin (11.7% +/- 6.4% positive cells, P =.013) compared with the P-selectin profile among controls (102.6 +/- 29.0 ng/mL, 4.1% +/- 1.2% positivity) and among patients with noncardiac chest pain (114.7 +/- 36.6 ng/mL, 5.7% +/- 2.9% positivity).
Positive_regulation (elevated) of Gene_expression (levels) of P-selectin in chest
11) Confidence 0.48 Published 2000 Journal Am. Heart J. Section Body Doc Link 10650306 Disease Relevance 0.17 Pain Relevance 0
Patients with a cardiac problem (unstable angina, congestive heart failure, acute myocardial infarction) had significantly elevated levels of soluble P-selectin (156.0 +/- 58.8 ng/mL, P =.002) and platelet-bound P-selectin (11.7% +/- 6.4% positive cells, P =.013) compared with the P-selectin profile among controls (102.6 +/- 29.0 ng/mL, 4.1% +/- 1.2% positivity) and among patients with noncardiac chest pain (114.7 +/- 36.6 ng/mL, 5.7% +/- 2.9% positivity).
Positive_regulation (elevated) of Gene_expression (levels) of P-selectin in chest
12) Confidence 0.48 Published 2000 Journal Am. Heart J. Section Body Doc Link 10650306 Disease Relevance 0.17 Pain Relevance 0
Increased levels of soluble adhesion molecules E-selectin and P-selectin in patients with cardiac syndrome X.
Positive_regulation (Increased) of Gene_expression (levels) of P-selectin associated with syndrome and adhesions
13) Confidence 0.30 Published 2005 Journal Angiology Section Title Doc Link 15889194 Disease Relevance 1.09 Pain Relevance 0.25
There was a significant increase in basal expression of P-selectin in blood platelets taken from patients who underwent CABG under normothermic conditions (warm blood cardioplegia) as opposed to hypothermic patients (cold crystalloid cardioplegia).
Positive_regulation (increase) of Gene_expression (expression) of P-selectin in blood platelets
14) Confidence 0.28 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 11122546 Disease Relevance 0.14 Pain Relevance 0.19
This effect was partially reversed when platelets washed from the same blood sample were used, but even then P-selectin expression was significantly lower in PTCA patients than it was in control subjects.
Positive_regulation (lower) of Gene_expression (expression) of P-selectin in blood
15) Confidence 0.19 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 11122546 Disease Relevance 0.13 Pain Relevance 0.19
Patients with unstable angina had elevated levels of P-selectin, which seems to be associated with enhanced platelet and leukocyte activation.
Positive_regulation (elevated) of Gene_expression (levels) of P-selectin in platelet
16) Confidence 0.19 Published 2001 Journal Pol. Arch. Med. Wewn. Section Body Doc Link 12026533 Disease Relevance 0 Pain Relevance 0
GTN inhibited platelet fibrinogen binding and expression of P-selectin at rest and in response to agonist stimulation, whereas amlodipine enhanced P-selectin expression and atenolol increased fibrinogen binding in response to agonists.
Positive_regulation (enhanced) of Gene_expression (expression) of P-selectin in platelet
17) Confidence 0.18 Published 1997 Journal Circulation Section Body Doc Link 8994427 Disease Relevance 0 Pain Relevance 0
Median P-selectin expression was significantly increased in H pylori-positive patients compared with seronegative patients (0.815 vs 0.65; P =.039).
Positive_regulation (increased) of Gene_expression (expression) of P-selectin
18) Confidence 0.16 Published 2004 Journal J. Vasc. Surg. Section Body Doc Link 14981449 Disease Relevance 0.09 Pain Relevance 0
Atherectomy specimens had significantly greater P-selectin expression from patients with unstable angina than from patients with stable angina.
Positive_regulation (greater) of Gene_expression (expression) of P-selectin associated with angina
19) Confidence 0.15 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9070552 Disease Relevance 1.62 Pain Relevance 0.91
Both agonist-induced fibrinogen binding and P-selectin expression were, however, higher in the young subjects compared with either the older control group or the patients (P < .05).
Positive_regulation (induced) of Gene_expression (expression) of P-selectin associated with agonist
20) Confidence 0.14 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351370 Disease Relevance 0.29 Pain Relevance 0.25

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