INT67450

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Context Info
Confidence 0.06
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 131 100.00 Very High Very High Very High
Morphine 8 99.18 Very High Very High Very High
antagonist 37 98.30 Very High Very High Very High
mu opioid receptor 2 88.88 High High
Opioid 15 85.20 High High
withdrawal 3 84.64 Quite High
narcan 1 68.56 Quite High
analgesia 20 50.00 Quite Low
agonist 12 26.08 Quite Low
Enkephalin 7 25.00 Low Low
Disease Link Frequency Relevance Heat
Squamous Cell Carcinoma 1 86.36 High High
Opiate Addiction 2 85.20 High High
Bordatella Infection 1 67.52 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

32 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

15 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Colitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged exposure of the cells to morphine (10 microM; 2 d) resulted in homologous desensitization of MOR function as well as heterologous sensitization of adenylate cyclase (AC).
Negative_regulation (desensitization) of Localization (sensitization) of MOR associated with morphine
1) Confidence 0.06 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996236 Disease Relevance 0.24 Pain Relevance 0.67
Similarly, CTAP was effective in preventing MOR internalization induced by DAMGO but only partially prevented cytosolic MOR translocation induced by Na2S treatment (Figure 6, panel B).


Negative_regulation (prevented) of Localization (translocation) of MOR associated with antagonist and opioid receptor
2) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.59

General Comments

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