INT67457

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Context Info
Confidence 0.24
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.28
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rara) nucleus (Rara) enzyme binding (Rara)
DNA binding (Rara) transcription factor binding (Rara) cytoplasm (Rara)
Anatomy Link Frequency
lung 2
neurites 1
Rara (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 128 95.84 Very High Very High Very High
Sciatic nerve 12 91.84 High High
Central nervous system 68 89.68 High High
Pain 14 89.60 High High
Inflammatory response 58 81.20 Quite High
dexamethasone 366 71.88 Quite High
cytokine 57 71.12 Quite High
ischemia 5 68.80 Quite High
alcohol 6 68.40 Quite High
agonist 36 64.00 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 623 100.00 Very High Very High Very High
Pressure And Volume Under Development 5 98.00 Very High Very High Very High
Necrosis 6 97.52 Very High Very High Very High
Carcinoma 5 93.92 High High
Wallerian Degeneration 4 91.12 High High
Targeted Disruption 49 90.88 High High
Pain 17 89.60 High High
Injury 82 87.44 High High
Disease 20 86.48 High High
Hypersensitivity 5 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell culture experiments indicated that RAR?
RAR Binding (indicated) of
1) Confidence 0.24 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.04 Pain Relevance 0.14
neurites, implying the involvement of RAR?
RAR Binding (involvement) of in neurites
2) Confidence 0.24 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.24 Pain Relevance 0.41
factor complex consists of an RAR/RXR heterodimer, ligand, and coactivators.
RAR Binding (heterodimer) of
3) Confidence 0.24 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.53 Pain Relevance 0.13
Statistically significant associations with RAR were older recipient age (p = 0.01), donor-recipient race mismatch (White donor to Black recipient) (p = 0.007), and dialysis requirement (p < 0.001).
RAR Binding (associations) of
4) Confidence 0.23 Published 1996 Journal Clin Transplant Section Abstract Doc Link 8996757 Disease Relevance 0.72 Pain Relevance 0.15
neurotrophin-independent RA/RAR?
RAR Binding (independent) of associated with rheumatoid arthritis
5) Confidence 0.21 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.84 Pain Relevance 0.12
Both isomers are able to bind to RAR, while only 9cRA can bind to RXR.
RAR Binding (bind) of
6) Confidence 0.17 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0.73 Pain Relevance 0.17
Using ChIP assays, ASH2, ALR and NCoA6(ASC-2) were reported to be recruited to the RAR?
RAR Binding (recruited) of
7) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.08 Pain Relevance 0
Alitretinoin (9-cis RA) is an endogenous retinoid with high binding affinity for both RAR and RXR receptor families.
RAR Binding (affinity) of associated with rheumatoid arthritis
8) Confidence 0.04 Published 2000 Journal Ann. Oncol. Section Abstract Doc Link 11142476 Disease Relevance 0.80 Pain Relevance 0
ATRA binds RAR with high affinity but does not bind to RXR, whereas 9-cis-RA, an isomer of ATRA, is a ligand that binds and transactivates both RARs and RXRs.
RAR Binding (binds) of associated with rheumatoid arthritis
9) Confidence 0.04 Published 1998 Journal Clin. Cancer Res. Section Abstract Doc Link 9626460 Disease Relevance 0.88 Pain Relevance 0
In addition, the regulation of free all-trans-RA by RA-binding proteins and interactions with RA receptors (RAR and RXR) contribute to appropriate lung development.
RAR Binding (interactions) of in lung associated with rheumatoid arthritis
10) Confidence 0.03 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.82 Pain Relevance 0.10
In addition, the regulation of free all-trans-RA by RA-binding proteins and interactions with RA receptors (RAR and RXR) contribute to appropriate lung development.
RAR Binding (binding) of in lung associated with rheumatoid arthritis
11) Confidence 0.03 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.82 Pain Relevance 0.12
For example, RAR-?
RAR Binding (example) of
12) Confidence 0.03 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.79 Pain Relevance 0.10

General Comments

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