INT67468

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Context Info
Confidence 0.44
First Reported 1996
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 4.40
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN5A)
Anatomy Link Frequency
pituitary 2
oocyte 2
embryos 1
sperm 1
SCN5A (Homo sapiens)
SCN5A - P1332L (1)
Pain Link Frequency Relevance Heat
Mexiletine 21 100.00 Very High Very High Very High
tetrodotoxin 12 100.00 Very High Very High Very High
Desipramine 6 100.00 Very High Very High Very High
agonist 42 99.88 Very High Very High Very High
Dismenorea 6 99.68 Very High Very High Very High
anesthesia 6 99.40 Very High Very High Very High
endometriosis 6 99.22 Very High Very High Very High
lidocaine 7 98.90 Very High Very High Very High
Nicotine 4 98.32 Very High Very High Very High
sodium channel 10 97.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Arrhythmia 17 99.78 Very High Very High Very High
Dysmenorrhea 6 99.68 Very High Very High Very High
Endometriosis (extended) 15 99.22 Very High Very High Very High
Recurrence 5 97.56 Very High Very High Very High
Reprotox - General 1 30 93.12 High High
Colon Cancer 5 91.88 High High
Neuroblastoma 2 88.40 High High
Ovarian Hyperstimulation Syndrome 22 88.24 High High
Cancer 7 87.64 High High
Diabetes Mellitus 397 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 atrioventricular (AV) block in a newborn with an SCN5A (P1332L) mutation[11], in a another case neither mexiletine nor flecainide was useful in long-term control of QT prolongation in a neonate with another SCN5A mutation (R1623Q)[9].
Regulation (control) of SCN5A (P1332L) associated with mexiletine
1) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.35 Pain Relevance 0.20
Intrinsic lidocaine affinity for Na channels expressed in Xenopus oocytes depends on alpha (hH1 vs. rSkM1) and beta 1 subunits.
Regulation (depends) of hH1 in oocytes associated with lidocaine
2) Confidence 0.44 Published 1999 Journal Cardiovasc. Res. Section Title Doc Link 10533585 Disease Relevance 0 Pain Relevance 0.33
The function of GPD1-L is poorly known at present, but preliminary in vitro data suggest that it controls the membrane expression of the sodium channels and that the mutation reduces the amount of sodium current similar to that observed for other BrS mutations affecting SCN5A.
Regulation (affecting) of SCN5A associated with heart arrhythmia and sodium channel
3) Confidence 0.44 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.66 Pain Relevance 0.19
Men explained that it was their wife's decision not to continue further IVF treatment and they did not always agree with their spouse's decision, and frustration over the decision was expressed.
Neg (not) Regulation (continue) of IVF
4) Confidence 0.37 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.13 Pain Relevance 0
Men and women, who had undergone IVF or ICSI (intra-cytoplasmic sperm injection) treatment at the Centre of Reproduction, University Hospital, Uppsala, Sweden, participated.
Regulation (undergone) of IVF in sperm
5) Confidence 0.37 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.11 Pain Relevance 0.06
After successfully and unambiguously passing the intake assessment, the candidates were enrolled for IVF in one of three selected IVF clinics in the Netherlands (the Reinier de Graaf Hospital in Voorburg, the Academic Medical Centre University Hospital in Amsterdam or the University Hospital in Groningen).
Regulation (enrolled) of IVF
6) Confidence 0.36 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2806181 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Adenomyosis had no adverse effects on IVF/ICSI outcomes in infertile women with proven endometriosis who were pretreated with long-term GnRH-agonist.


Neg (no) Regulation (effects) of IVF/ICSI
7) Confidence 0.35 Published 2010 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Body Doc Link 20409633 Disease Relevance 0 Pain Relevance 0
Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI.
Neg (no) Regulation (effects) of IVF/ICSI in pituitary associated with endometriosis and dismenorea
8) Confidence 0.35 Published 2010 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Title Doc Link 20409633 Disease Relevance 0.20 Pain Relevance 0.33
OBJECTIVE: To compare the efficacy and safety of Bravelle s.c., Bravelle i.m., and Follistim s.c. in patients undergoing controlled ovarian hyperstimulation for IVF-ET.
Regulation (controlled) of IVF-ET
9) Confidence 0.34 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12057729 Disease Relevance 0 Pain Relevance 0
CONCLUSION(S): Bravelle s.c. and Bravelle i.m. are comparable in efficacy and safety to Follistim s.c. in patients undergoing controlled ovarian hyperstimulation for IVF-ET.


Regulation (controlled) of IVF-ET
10) Confidence 0.34 Published 2002 Journal Fertil. Steril. Section Body Doc Link 12057729 Disease Relevance 0 Pain Relevance 0
Despite this avoidance of further debate on destruction of embryos, the utility of affected or non-viable PGD and in-vitro fertilisation (IVF) embryos for stem cell research (as one of the more controversial beneficiaries of PGD and IVF embryos not used for treatment), has reopened some of the previous discussions (Franklin 1997, Parry 2003).
Regulation (affected) of IVF in embryos
11) Confidence 0.34 Published 2008 Journal Sociology of Health & Illness Section Body Doc Link PMC2592482 Disease Relevance 0 Pain Relevance 0
The study population consists of twins and singletons born from IVF between 2003 and 2005, of whom parents have received IVF treatment in one of the five participating IVF centres in the Netherlands (Academic Medical Centre, Maastricht University Medical Centre, Radboud University Nijmegen Medical Centre, Erasmus Medical Centre and University Medical Center Utrecht).
Regulation (received) of IVF
12) Confidence 0.32 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2978208 Disease Relevance 0 Pain Relevance 0
Kahn carefully describes how these rabbinical debates and decisions affect the actual practice of Israeli IVF.
Regulation (affect) of IVF
13) Confidence 0.28 Published 2006 Journal Cult Med Psychiatry Section Body Doc Link PMC1705533 Disease Relevance 0.13 Pain Relevance 0.05
The degree to which these official Sunni Islamic fatwas on IVF have affected the actual practices of the Middle Eastern medical profession is also quite striking.
Regulation (affected) of IVF
14) Confidence 0.28 Published 2006 Journal Cult Med Psychiatry Section Body Doc Link PMC1705533 Disease Relevance 0 Pain Relevance 0
In both Egypt and Lebanon, as in other Muslim countries, nonbinding but authoritative Islamic religious proclamations called fatwas have profoundly affected the practice of IVF in ways that are not commonly seen in the West.
Regulation (affected) of IVF
15) Confidence 0.28 Published 2006 Journal Cult Med Psychiatry Section Body Doc Link PMC1705533 Disease Relevance 0 Pain Relevance 0
Na(+) channel activity and invasive potential were inhibited pharmacologically by tetrodotoxin or genetically by small interfering RNAs (siRNA) specifically targeting SCN5A.
Regulation (targeting) of SCN5A associated with tetrodotoxin
16) Confidence 0.27 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20651255 Disease Relevance 0.49 Pain Relevance 0.10
Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI.
Regulation (regulation) of IVF/ICSI in pituitary associated with endometriosis and dismenorea
17) Confidence 0.25 Published 2010 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Title Doc Link 20409633 Disease Relevance 0.20 Pain Relevance 0.34
The purposes of this study were to determine the efficacy of propofol anesthesia for oocyte retrieval and its effect on IVF outcomes.
Regulation (effect) of IVF in oocyte associated with anesthesia
18) Confidence 0.23 Published 1996 Journal J Med Assoc Thai Section Abstract Doc Link 8996995 Disease Relevance 0.21 Pain Relevance 0.34
In a prospective study comparing the efficacy of IVF and ICSI after TFF in a previous IVF attempt, the fertilization rate in a second cycle was significantly higher after ICSI than after IVF (48% respectively 11%, P < 0.001).
Regulation (efficacy) of IVF
19) Confidence 0.20 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2632644 Disease Relevance 0.26 Pain Relevance 0
It has been demonstrated that in a GnRHa down- regulated IVF patients, the response to FSH is independent of serum LH levels at the time of starting FSH administration or on the day of hCG administration [22,23].
Regulation (regulated) of IVF
20) Confidence 0.19 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.07 Pain Relevance 0

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