INT67488

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Context Info
Confidence 0.31
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 4.60
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pc) ligase activity (Pc)
Anatomy Link Frequency
brains 1
dopaminergic neurons 1
Pc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
endometriosis 356 100.00 Very High Very High Very High
ischemia 11 98.50 Very High Very High Very High
Dismenorea 27 74.68 Quite High
alcohol 16 74.56 Quite High
Potency 9 71.64 Quite High
antagonist 4 29.32 Quite Low
agonist 3 28.60 Quite Low
Inflammation 7 25.00 Low Low
Central nervous system 1 25.00 Low Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 360 100.00 Very High Very High Very High
Stroke 28 99.50 Very High Very High Very High
Disease 74 99.34 Very High Very High Very High
Brain Hemorrhage 8 98.50 Very High Very High Very High
Spontaneous Abortion 96 92.48 High High
Premature Birth 42 90.72 High High
Reprotox - General 3 40 89.84 High High
Toxicity 37 86.40 High High
Parkinson's Disease 1 84.76 Quite High
Parkinsonian Disorders 1 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The uteri were more sensitive to PCB congeners with ortho-substituted light chlorination than those highly chlorinated, or those interacting with the Ah-receptor.
PCB Binding (interacting) of
1) Confidence 0.31 Published 1996 Journal Reprod. Toxicol. Section Abstract Doc Link 8998381 Disease Relevance 0.14 Pain Relevance 0.14
ORs and 95% confidence intervals (CIs) for the risk of endometriosis in association with serum PCB concentrations were estimated using unconditional logistic regression.
PCB Binding (association) of associated with endometriosis
2) Confidence 0.31 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.10 Pain Relevance 0.12
The most recent of these, an Italian case–control study, reported an odds ratio (OR) as high as 4.9 for the association between PCB 153 exposure and endometriosis (Porpora et al. 2009).
PCB Binding (association) of associated with endometriosis
3) Confidence 0.31 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.77 Pain Relevance 0.27
In contrast to that study, our study was not restricted to nulliparous women; however, we did evaluate our PCB–endometriosis associations stratified by parity, and our conclusions were not substantially different among nulliparous women.
PCB Binding (associations) of associated with endometriosis
4) Confidence 0.30 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.76 Pain Relevance 0.35
For those congeners with > 25% of samples below the limit of detection (PCB congeners 87, 101, 128, 149, 151, 157, 167, 172, 177, 178, 183, and 189), the percentage of quantified samples did not differ by disease status, nor were the quantified PCB congeners associated with endometriosis in analyses of categorized PCB concentration with observations below the detection limit included in the reference category (results not shown).
PCB Spec (analyses) Binding (associated) of associated with endometriosis and disease
5) Confidence 0.30 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.40 Pain Relevance 0.15
Although there are only a few studies evaluating groups with high levels of exposure, these studies are particularly informative with regard to the association between PCB and dioxin consumption and pregnancy outcomes.
PCB Binding (association) of
6) Confidence 0.29 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2367658 Disease Relevance 0.46 Pain Relevance 0
Our study supports an association between PCB and dioxin exposure and adverse pregnancy outcomes.
PCB Binding (association) of
7) Confidence 0.29 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2367658 Disease Relevance 0.44 Pain Relevance 0.05
The aim of this study was to investigate the association of maternal PCB and dioxin exposure with adverse pregnancy outcomes in Yusho women.


PCB Binding (association) of
8) Confidence 0.28 Published 2008 Journal Environ Health Perspect Section Abstract Doc Link PMC2367658 Disease Relevance 0.55 Pain Relevance 0
Interestingly, our analyses did not detect PCB congeners above control levels in the brains of adult animals exposed developmentally to A1254 at 0.1 mg/kg/day, even though this dose was neuroprotective against focal cerebral ischemia in females, suggesting that PCB effects on stroke outcome may result from PCB interactions with developmental processes.
PCB Binding (interactions) of in brains associated with brain hemorrhage, stroke and ischemia
9) Confidence 0.28 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.32 Pain Relevance 0.05
The possibility that orally administered PCB could reach the brain parenchyma in sufficient concentrations to influence microglial function is consistent with the findings of two rodent studies: orally administered C-phycocyanin (the spirulina holoprotein that includes PCB) suppresses the neurotoxic impact of the excitotoxin kainite in rats, and a diet high in spirulina ameliorates the loss of dopaminergic neurons in the MPTP-induced Parkinsonian syndrome in mice.
PCB Binding (administered) of in dopaminergic neurons associated with parkinson's disease and parkinsonian disorders
10) Confidence 0.12 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19576698 Disease Relevance 0.47 Pain Relevance 0
Conversely, biological activity associated with ortho-substituted PCB congeners is unaffected or increased by remediation.
PCB Binding (associated) of
11) Confidence 0.03 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1277862 Disease Relevance 0.19 Pain Relevance 0

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