INT6749

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 4.41
Pain Relevance 13.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
nucleus accumbens 1
medial 1
lateral 1
brain 1
Dio1 1
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 584 100.00 Very High Very High Very High
Enkephalin 23 100.00 Very High Very High Very High
dopamine receptor 44 99.96 Very High Very High Very High
Nucleus accumbens 53 99.84 Very High Very High Very High
Opioid 22 99.82 Very High Very High Very High
antinociception 12 99.18 Very High Very High Very High
Morphine 80 99.12 Very High Very High Very High
Cannabinoid 65 99.12 Very High Very High Very High
Eae 15 98.84 Very High Very High Very High
Neurotransmitter 77 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 92 100.00 Very High Very High Very High
Urological Neuroanatomy 16 98.64 Very High Very High Very High
Cancer 121 97.04 Very High Very High Very High
Catalepsy 10 91.84 High High
Skin Cancer 106 89.80 High High
Parkinson's Disease 40 85.52 High High
Neuroblastoma 94 85.44 High High
Dwarfism 2 81.16 Quite High
Disease 62 79.28 Quite High
Targeted Disruption 23 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is well known that methamphetamine- and morphine-induced hyperlocomotion are mediated by the dopaminergic system and that interaction between postsynaptic D1- and D2-receptors may play an important role in the expression of various dopamine-mediated behaviors.
D1 Binding (interaction) of associated with dopamine and morphine
1) Confidence 0.38 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10928323 Disease Relevance 0 Pain Relevance 0.73
In vitro binding affinity (Ki) of these drugs to the D1 and D2 receptors in the striatum synaptic membrane was within the range of 60 nM to 706 microM, 0.5 nM to 75 microM and 860 nM to 115 microM, respectively.
D1 Binding (affinity) of in striatum
2) Confidence 0.37 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808703 Disease Relevance 0.48 Pain Relevance 0.17
TIQ binding to cortical adrenergic alpha1, alpha2 and beta receptors, striatal dopamine D1 and D2 receptors and cortical L-type calcium channels in the Wistar rat was also studied.
D1 Binding (binding) of associated with dopamine and calcium channel
3) Confidence 0.36 Published 2001 Journal J Neural Transm Section Abstract Doc Link 11459073 Disease Relevance 0.08 Pain Relevance 0.58
Striatal dopaminergic activity was evaluated by measuring: a) the ratio between the amounts of L-3,4-dihydroxyphenylacetic acid (DOPAC), the main intraneuronal metabolite of dopamine (DA), and the neurotransmitter itself, as an index of presynaptic activity; and b) the number and affinity of D1 and D2 dopaminergic receptors, as well as the amount of their coupled second messenger, cyclic adenosine monophosphate (cAMP), as postsynaptic parameters.
D1 Binding (affinity) of associated with adenocard, neurotransmitter and dopamine
4) Confidence 0.36 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1332081 Disease Relevance 0 Pain Relevance 0.91
Moreover, dopamine D1 and D2 receptor binding was measured.
D1 Binding (binding) of associated with dopamine
5) Confidence 0.34 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11919654 Disease Relevance 0 Pain Relevance 0.57
Except for a slight increase in the lateral septum, D1 receptor binding did not differ from wild-type in twenty-one other neocortical, limbic or basal ganglia regions examined in the KO.
D1 Binding (binding) of in lateral
6) Confidence 0.32 Published 2008 Journal J. Chem. Neuroanat. Section Abstract Doc Link 18406571 Disease Relevance 0.15 Pain Relevance 0.53
These findings suggest that delta but not mu opioid systems interact with D1 dopamine receptors, resulting in a marked increase in linear locomotion and contralateral circuling without causing marked changes in grooming behavior.
D1 Binding (interact) of associated with dopamine receptor and opioid
7) Confidence 0.29 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1354161 Disease Relevance 0 Pain Relevance 1.00
We explored the functional relevance of the interaction between dopamine D1 and D2 receptors and cannabinoid CB1 receptors with behavioral pharmacology experiments.
D1 Binding (interaction) of associated with dopamine and cannabinoid
8) Confidence 0.28 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17957223 Disease Relevance 0 Pain Relevance 0.91
It is interesting to note, however, that Dio1 (iodothyronine deiodinase), which is downregulated in most dwarf mouse strains and under CR (see Fig. 8), has been associated with positive selection and accelerated evolution within the mouse-chimp-human lineage (see supplemental data from [74]).
Dio1 Binding (associated) of in Dio1 associated with sprains and strains
9) Confidence 0.26 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.76 Pain Relevance 0
The distribution of this transient c-fos response corresponded to the early striosomal compartment since it matched with the regions of intense mu-opioid and dopamine-D1 receptor binding, as assessed by autoradiography performed on adjacent sections.
D1 Binding (binding) of associated with dopamine and opioid
10) Confidence 0.26 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.40
Upregulated dopamine D2-like binding and enkephalin in D1(-/-) mice may be due to decreased dopamine turnover.
D1 Binding (binding) of associated with dopamine and enkephalin
11) Confidence 0.25 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.28 Pain Relevance 1.41
We have evaluated the functional interaction between the D1 and D2 DA receptor subtypes at the cellular and behavioral levels.
D1 Binding (interaction) of associated with dopamine
12) Confidence 0.22 Published 2002 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12048106 Disease Relevance 0.13 Pain Relevance 0.50
The binding data revealed that S14905 has a high affinity for sigma receptors and very low affinity for both dopamine D1 and D2 receptors.
D1 Binding (affinity) of associated with dopamine
13) Confidence 0.21 Published 1995 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8998401 Disease Relevance 0 Pain Relevance 0.36
Morphine-induced antinociception in the formalin test: sensitization and interactions with D1 and D2 dopamine receptors and nitric oxide agents.
D1 Binding (interactions) of associated with antinociception, dopamine receptor and morphine
14) Confidence 0.20 Published 2007 Journal Behav Pharmacol Section Title Doc Link 17426481 Disease Relevance 0 Pain Relevance 1.35
Noteworthy, the D6 inhibitory effect was already evident at early days of treatment, and it was more statistically efficacious than D1 (D6 vs D1, P < 0.01).
D1 Binding (efficacious) of
15) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.91 Pain Relevance 0.06
Noteworthy, the D6 inhibitory effect was already evident at early days of treatment, and it was more statistically efficacious than D1 (D6 vs D1, P < 0.01).
D1 Binding (efficacious) of
16) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.92 Pain Relevance 0.06
However, the combined administration of the D1 and D2 agonists (+)-SKF81297 plus quinpirole restored movement and induced forward locomotion (Figure 4J), supporting the well-established cooperative interaction of D1 and D2-like DA receptors in locomotor activity [62].


D1 Binding (interaction) of associated with dopamine, eae and agonist
17) Confidence 0.17 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.09 Pain Relevance 0.61
To determine whether dopamine acting through D1 receptors mediates light resetting of retinal PER2::LUC rhythms, we applied the D1 receptor antagonist SCH-23390 (50 ?
D1 Binding (receptors) of associated with dopamine and antagonist
18) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.31
In doing so, the antibodies failed to bind the corresponding epitopes on the surface CB1Rs (compare Fig. 2A and 2C), but reached the intact epitopes on the internalized CB1Rs (Nt, D1 and E1; 1EL, D2 and E2).
D1 Binding (internalized) of
19) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.06 Pain Relevance 0.39
The Comt variant causes downstream differences in the expression of genes involved in synaptic function, and also modulates phenotypes such as dopamine D1 and D2 receptor binding and pharmacological responses to haloperidol.


D1 Binding (binding) of associated with dopamine
20) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923157 Disease Relevance 0.26 Pain Relevance 0.15

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