INT6750

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Context Info
Confidence 0.28
First Reported 1983
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.01
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Klkb1) extracellular space (Klkb1) extracellular region (Klkb1)
molecular_function (Klkb1) cellular_component (Klkb1) biological_process (Klkb1)
Anatomy Link Frequency
plasma 6
Klkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 99.52 Very High Very High Very High
fluoxetine 1 99.20 Very High Very High Very High
addiction 1 98.96 Very High Very High Very High
Clonidine 4 98.12 Very High Very High Very High
sSRI 1 97.72 Very High Very High Very High
Serotonin 1 97.58 Very High Very High Very High
antidepressant 1 96.56 Very High Very High Very High
noradrenaline 2 96.48 Very High Very High Very High
Opioid 1 93.28 High High
antagonist 3 92.72 High High
Disease Link Frequency Relevance Heat
Stress 12 99.98 Very High Very High Very High
Phobia 3 99.56 Very High Very High Very High
Anxiety Disorder 4 95.92 Very High Very High Very High
Syndrome 1 95.60 Very High Very High Very High
Panic Disorder 1 84.28 Quite High
Epilepsy 2 74.16 Quite High
Affective Disorder 2 73.12 Quite High
Depression 2 67.52 Quite High
Pressure And Volume Under Development 1 49.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Panic-induced elevation of plasma MHPG levels in phobic-anxious patients.
Positive_regulation (elevation) of plasma MHPG in plasma associated with phobia
1) Confidence 0.28 Published 1983 Journal Arch. Gen. Psychiatry Section Title Doc Link 6838322 Disease Relevance 0.71 Pain Relevance 0.26
Plasma hormone levels increased within 5 min after the termination of the stimulus, while no marked changes were found during stimulation.
Positive_regulation (increased) of Plasma hormone in Plasma
2) Confidence 0.05 Published 1983 Journal J. Endocrinol. Section Abstract Doc Link 6833931 Disease Relevance 0 Pain Relevance 0.48
Neuropeptide Y (NPY) administration increases both hypothalamic corticotropin-releasing factor-like immunoreactivity (CRF-ir) and plasma adrenocorticotropin (ACTH).
Positive_regulation (increases) of plasma adrenocorticotropin in plasma associated with neuropeptide
3) Confidence 0.04 Published 1989 Journal Brain Res. Section Abstract Doc Link 2551461 Disease Relevance 0 Pain Relevance 0.32
Pretreatment of chronically stressed rats with NALT before reexposure to stress resulted in plasma hormone levels that were not different from those in animals pretreated with SAL.
Positive_regulation (resulted) of plasma hormone in plasma associated with stress
4) Confidence 0.02 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1332097 Disease Relevance 0.90 Pain Relevance 0.27
The newer antidepressants that selectively inhibit the reuptake of serotonin (SSRIs), although in different fashions for the different substances (fluoxetine, fluvoxamine, paroxetine) may cause an increase of plasma AED levels through inhibition of the isoenzyme P450 2D6.
Positive_regulation (increase) of plasma AED in plasma associated with antidepressant, ssri, serotonin and fluoxetine
5) Confidence 0.02 Published 1999 Journal Epilepsia Section Abstract Doc Link 10609607 Disease Relevance 0.28 Pain Relevance 0.66
Interleukin-1 beta i.c.v. stimulated the release of vasopressin above that elicited by PBS-BSA alone in non-lactating rats resulting in an approximate 1.2 to 2-fold increase in plasma hormone levels.
Positive_regulation (increase) of plasma hormone in plasma
6) Confidence 0.02 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8953469 Disease Relevance 0.12 Pain Relevance 0.10

General Comments

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