INT67522

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
PGE1 2
embryonic kidney 2
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 16 100.00 Very High Very High Very High
agonist 9 100.00 Very High Very High Very High
Opioid 4 98.40 Very High Very High Very High
tolerance 4 98.12 Very High Very High Very High
Enkephalin 10 94.16 High High
MU agonist 1 27.40 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Glioma 1 70.40 Quite High
Neuroblastoma 1 70.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of agonist-induced down-regulation of the delta-opioid receptor with a proteasome inhibitor attenuates opioid tolerance in human embryonic kidney 293 cells.
Negative_regulation (Inhibition) of Negative_regulation (regulation) of delta-opioid receptor in embryonic kidney associated with tolerance, agonist, opioid receptor and opioid
1) Confidence 0.37 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.28
Inhibitors of protein kinase A (PKA) partially reversed the PGE1- and db-cAMP-mediated repression of the delta-opioid receptor mRNA levels.
Negative_regulation (reversed) of Negative_regulation (repression) of delta-opioid receptor mRNA in PGE1 associated with repression and opioid receptor
2) Confidence 0.04 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9003047 Disease Relevance 0.24 Pain Relevance 0.35

General Comments

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