INT67568

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Context Info
Confidence 0.31
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.58
Pain Relevance 6.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
THP-1 6
HL-60 4
fibroblasts 2
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 678 100.00 Very High Very High Very High
Nicotine 172 99.98 Very High Very High Very High
rheumatoid arthritis 304 96.16 Very High Very High Very High
Morphine 8 94.80 High High
Kinase C inhibitor 1 83.84 Quite High
chemokine 61 79.28 Quite High
Osteoarthritis 32 76.00 Quite High
Inflammation 155 74.36 Quite High
cytokine 236 73.12 Quite High
Kinase C 2 68.48 Quite High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 715 99.98 Very High Very High Very High
Skin Cancer 7 99.86 Very High Very High Very High
Sarcoma 237 97.72 Very High Very High Very High
Infection 316 97.44 Very High Very High Very High
Adhesions 148 96.88 Very High Very High Very High
Rheumatoid Arthritis 304 96.16 Very High Very High Very High
Endometriosis (extended) 40 93.84 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 18 93.64 High High
Hypercalcemia 5 93.28 High High
Hepatitis B Virus Infection 3 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated secretion of pro-MMP-2 and MMP-2 was observed in the co-culture of differentiated THP-1 cells and fibroblasts (Fig. 5b).


Positive_regulation (Elevated) of Localization (secretion) of MMP-2 in THP-1 associated with metalloproteinase
1) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.39 Pain Relevance 0.65
Our studies report for the first time the role of KSHV induced MMP-2 and MMP-9 (Figure 8) secretion in HMVEC-d and latently infected TIVE-LTC cells.
Positive_regulation (induced) of Localization (secretion) of MMP-2 associated with herpes simplex virus and metalloproteinase
2) Confidence 0.24 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.44 Pain Relevance 0.56
In agreement with MMP-antibody array data, we observed a 3.3, 3.3, and 3.5-fold induction in total MMP-2 release at 4h, 8h, and 24h PI (Figures 9E and 9F).
Positive_regulation (induction) of Localization (release) of MMP-2 associated with metalloproteinase
3) Confidence 0.24 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.33 Pain Relevance 0.79
The gel zymography results show that MMP-9 and MMP-2 secretion increased significantly in the co-culture of isolated human CD14+ monocytes and fibroblasts for both the RA and normal control groups compared with the cultures of human monocytes or fibroblasts alone (Fig. 4).
Positive_regulation (increased) of Localization (secretion) of MMP-2 in fibroblasts associated with rheumatoid arthritis and metalloproteinase
4) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.68 Pain Relevance 0.89
The co-culture of undifferentiated THP-1 cells and fibroblasts showed a significantly elevated level of release and activation of MMP-2 and particularly MMP-9 compared with the cultures of THP-1 cells or fibroblasts alone (Fig. 5a).
Positive_regulation (activation) of Localization (release) of MMP-2 in THP-1 associated with metalloproteinase
5) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.28 Pain Relevance 0.70
1 integrin receptors and the subsequent induction of MMP-2 secretion.
Positive_regulation (induction) of Localization (secretion) of MMP-2
6) Confidence 0.23 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.96 Pain Relevance 0
Elevated secretion of pro-MMP-2 and MMP-2 was observed in the co-culture of differentiated THP-1 cells and fibroblasts (Fig. 5b).


Positive_regulation (Elevated) of Localization (secretion) of pro-MMP-2 in THP-1 associated with metalloproteinase
7) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.39 Pain Relevance 0.64
Latently infected TIVE-LTC cells demonstrated roughly about 1.8 and 1.5-fold induction in the release of total and active-MMP-2 as compared to TIVE cells (Figure 9G).
Positive_regulation (induction) of Localization (release) of active-MMP-2 associated with metalloproteinase
8) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.50 Pain Relevance 0.68
We have reported previously that OPN expression in human melanoma cells increases CD44 surface expression, MMP-2 secretion, and cell migration [10].
Positive_regulation (increases) of Localization (secretion) of MMP-2 associated with skin cancer
9) Confidence 0.12 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.91 Pain Relevance 0.25
Nicotine augments the release of MMP-9, but not MMP-2, from HL-60 cells
Positive_regulation (augments) of Localization (release) of MMP-2 in HL-60 associated with nicotine
10) Confidence 0.06 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.36 Pain Relevance 0.40
Nicotine-exposure during differentiation promoted the release of MMP-9 (see Figure 7A and 7B), but not MMP-2, from LPS-stimulated HL-60 cells.
Positive_regulation (promoted) of Localization (release) of MMP-2 in HL-60 associated with nicotine
11) Confidence 0.04 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.40 Pain Relevance 0.39
The zymography, reverse transcriptase polymerase chain reaction (RT/PCR), ELISA, and MMP-2 gene promoter activity assays showed significantly increased MMP-2 secretion and expression.
Positive_regulation (increased) of Localization (secretion) of MMP-2 associated with metalloproteinase
12) Confidence 0.04 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.56 Pain Relevance 0.25
In addition, indolactam V promotes U937 cell secretion of a 92 kDa gelatinase as demonstrated by zymography.
Positive_regulation (promotes) of Localization (secretion) of gelatinase
13) Confidence 0.02 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598903 Disease Relevance 0.39 Pain Relevance 0.61
Piroxicam also decreased the release of gelatinase and lysozyme induced by TNF alpha, but not by PMA.
Neg (not) Positive_regulation (induced) of Localization (release) of gelatinase
14) Confidence 0.01 Published 1997 Journal Arthritis Rheum. Section Body Doc Link 9008610 Disease Relevance 0 Pain Relevance 0

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