INT67580

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.86
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Sell) plasma membrane (Sell)
Anatomy Link Frequency
neutrophils 4
granulocytes 2
leukocytes 2
Sell (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 25 100.00 Very High Very High Very High
diclofenac 21 96.56 Very High Very High Very High
Inflammatory response 3 94.88 High High
Kinase C 2 90.56 High High
antagonist 1 76.88 Quite High
Inflammation 1 59.04 Quite High
cytokine 2 50.00 Quite Low
chemokine 1 10.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 13 100.00 Very High Very High Very High
Adhesions 8 97.84 Very High Very High Very High
Hypertension 8 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the KD-IX-73-4, an inhibitor of L-selectin proteolysis was able to block the effect of NSAIDs on L-selectin expression.
Regulation (effect) of Gene_expression (expression) of L-selectin associated with cinod
1) Confidence 0.51 Published 2000 Journal Blood Section Abstract Doc Link 11071659 Disease Relevance 0.29 Pain Relevance 0.85
Venular shear rate, venular diameters, number of circulating leukocytes, and post-leukotriene B4 expression of l-selectin and CD11/CD18 integrin in leukocytes were unaffected by any treatment.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of l-selectin in leukocytes
2) Confidence 0.26 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716214 Disease Relevance 0.57 Pain Relevance 0.60
Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration.
Regulation (role) of Gene_expression (expression) of L-selectin in neutrophils associated with inflammation and cinod
3) Confidence 0.23 Published 2000 Journal Blood Section Title Doc Link 11071659 Disease Relevance 0.38 Pain Relevance 0.78
Neither treatment tested increased the venular shear rate or modified the venular diameters, number of circulating leukocytes, and L-selectin expression on granulocytes.
Neg (Neither) Regulation (modified) of Gene_expression (expression) of L-selectin in granulocytes
4) Confidence 0.19 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16044031 Disease Relevance 0.56 Pain Relevance 0.57
RESULTS: Pretreatment of neutrophils with either NSAID prevented the changes in L-selectin and CD11b expression induced by TNF alpha, GM-CSF, and FMLP, but not those induced by PMA or A23187.
Regulation (changes) of Gene_expression (expression) of L-selectin in neutrophils
5) Confidence 0.03 Published 1997 Journal Arthritis Rheum. Section Body Doc Link 9008610 Disease Relevance 0.06 Pain Relevance 0

General Comments

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