INT67589

Context Info Confidence 0.51 First Reported 1996 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 7.52 Pain Relevance 1.09

nucleus (MT1E) cytoplasm (MT1E)

Anatomy Link Frequency bladder 3 MT1E (Homo sapiens)

Pain Link Frequency Relevance Heat methadone 10 100.00 Peripheral nervous system 1 94.24 cva 4 92.40 Shingles 1 87.08 interstitial cystitis 3 84.28 Morphine 2 55.20 Codeine 2 54.40 cocaine 2 53.68 Pain 2 52.68 addiction 2 25.00

Disease Link Frequency Relevance Heat Herpes Zoster 14 99.98 Immunization 2 99.40 Pleural Effusion 4 99.32 Bladder Cancer 27 98.80 Cancer 40 96.68 Pressure And Volume Under Development 5 95.20 Toxicity 45 93.96 Cardiomegaly 1 93.08 Cv General 3 Under Development 2 92.40 Apoptosis 61 91.24

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Selective antibodies to (R)-methadone (Mtd) and to its racemate were produced in rabbits by immunization with conjugates of (R)- or (R,S)-hemisuccinyl-methadol-bovine serum albumin, respectively.

Gene_expression (produced) of Mtd associated with immunization and methadone

1) Confidence 0.51 Published 2001 Journal Chirality Section Abstract Doc Link 11284023 Disease Relevance 0.17 Pain Relevance 0.63

The expression of MT-1E mRNA was variable in both normal bladder and bladder cancer specimens.

Gene_expression (expression) of MT-1E mRNA in bladder associated with bladder cancer

2) Confidence 0.26 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.08 Pain Relevance 0.07

TB-MTD and culture were negative both in pericardial and pleural effusion.

Neg (negative) Gene_expression (negative) of TB-MTD associated with pleural effusion

3) Confidence 0.23 Published 2004 Journal Kekkaku Section Abstract Doc Link 15552940 Disease Relevance 1.84 Pain Relevance 0.14

DROSHA, ITGB4, IGF1R, MT1X, MT1E, BRAF) was likewise affected by Par-4 overexpression in HT29 cells (Figure 2A; see Additional file 2 for gene symbols and their corresponding gene names).

Gene_expression (overexpression) of MT1E

4) Confidence 0.21 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.52 Pain Relevance 0

The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer.

Gene_expression (expressed) of MT-1E in bladder associated with bladder cancer

5) Confidence 0.20 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.12 Pain Relevance 0.08

The expression of MT-1E mRNA was variable in both normal bladder and bladder cancer specimens.

Gene_expression (expression) of MT-1E mRNA in bladder associated with bladder cancer

6) Confidence 0.09 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.08 Pain Relevance 0.07

The MTD was reached at PLD doses of 30 and 40 mg/m2, every 21 or 28 days, and at TPT doses (0.5 to 1.0 mg/m2/day) administered with the classic shorter courses (days 1 to 3 or days 1 to 5).

Gene_expression (doses) of MTD

7) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 0.50 Pain Relevance 0

During latency, VZV expresses a limited set of transcripts of its immediate early (IE) and early (E) genes but no protein has been detected.

Gene_expression (expresses) of IE associated with herpes zoster

8) Confidence 0.02 Published 1996 Journal Vet. Microbiol. Section Abstract Doc Link 9010998 Disease Relevance 1.21 Pain Relevance 0.09

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