INT67604

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.47
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINC1) extracellular region (SERPINC1) plasma membrane (SERPINC1)
Anatomy Link Frequency
monocytes 1
thrombocytes 1
thrombocytes 1
SERPINC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 167 99.98 Very High Very High Very High
depression 1 99.24 Very High Very High Very High
cva 60 98.24 Very High Very High Very High
cytokine 45 93.28 High High
Pain 7 88.20 High High
Morphine 1 86.48 High High
analgesia 1 85.56 High High
anesthesia 29 80.80 Quite High
Analgesic 1 80.76 Quite High
Inflammatory stimuli 5 78.88 Quite High
Disease Link Frequency Relevance Heat
Salmonella Infection 1 100.00 Very High Very High Very High
Sickle Cell Anemia 1 100.00 Very High Very High Very High
INFLAMMATION 175 99.98 Very High Very High Very High
Chronic Renal Failure 5 99.88 Very High Very High Very High
Depression 1 99.24 Very High Very High Very High
Sepsis 178 99.16 Very High Very High Very High
Diabetes Mellitus 1 99.06 Very High Very High Very High
Coagulation Disorder 33 99.02 Very High Very High Very High
Malaria 22 98.80 Very High Very High Very High
Cv General 3 Under Development 13 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The coagulation profile showed a fibrinogen level of 879 mg/dl and antithrombin III value of 9.5%.
Gene_expression (level) of antithrombin III
1) Confidence 0.67 Published 2000 Journal Surg. Today Section Abstract Doc Link 10930236 Disease Relevance 0.92 Pain Relevance 0.20
Following the debridement under control of diabetes mellitus, antimicrobial agents and argatroban, a newly synthesized antithrombin medicine, were administered.
Gene_expression (synthesized) of antithrombin associated with diabetes mellitus
2) Confidence 0.60 Published 1996 Journal Hinyokika Kiyo Section Abstract Doc Link 9013237 Disease Relevance 0.54 Pain Relevance 0.09
In their investigations into the intracellular mechanisms that underlie the anti-inflammatory effects of antithrombin, Oelschläger and coworkers [48] confirmed that antithrombin inhibits activation of nuclear factor-?
Gene_expression (effects) of antithrombin associated with inflammation
3) Confidence 0.55 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.42 Pain Relevance 0.19
Effects of antithrombin on monocytes and thrombocytes
Gene_expression (Effects) of antithrombin in thrombocytes
4) Confidence 0.55 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.65 Pain Relevance 0.06
In sepsis, laboratory data demonstrate not only changes in the number of leucocytes but also a reduction in the number of thrombocytes and antithrombin concentration.


Gene_expression (concentration) of antithrombin in thrombocytes associated with sepsis
5) Confidence 0.55 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 1.06 Pain Relevance 0.12
The largest number of patients with acquired antithrombin deficiency treated with human plasmatic antithrombin in a prospective controlled clinical study can be found in the KyberSept trial [19].
Gene_expression (deficiency) of antithrombin
6) Confidence 0.55 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 1.13 Pain Relevance 0
Levels of protein C, S and antithrombin III were unreliable in the setting of an acute thromboembolic event or during treatment with heparin and coumadin.
Gene_expression (Levels) of antithrombin III associated with cva
7) Confidence 0.36 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2045103 Disease Relevance 0.83 Pain Relevance 0.08
In the present study, we measured a coagulation profile including antithrombin III (AT III) and fibrin degradation product (FDP) to evaluate the impact of ulinastatin on the coagulation system.
Gene_expression (degradation product) of antithrombin III
8) Confidence 0.27 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.50 Pain Relevance 0.12
In the present study, we measured a coagulation profile including antithrombin III (AT III) and fibrin degradation product (FDP) to evaluate the impact of ulinastatin on the coagulation system.
Gene_expression (profile) of antithrombin III
9) Confidence 0.27 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.50 Pain Relevance 0.12
Exploration of other causes of splenic infarction, including constitutional underlying coagulation disorder (C and S-protein, Leyden mutation, homocystein, antithrombin III and antibody antiphospholipid measurement), sickle cell disease (normal haemoglobin electrophoresis) and concomitant Salmonella infection, were negative.


Neg (negative) Gene_expression (negative) of antithrombin III associated with sickle cell anemia, coagulation disorder, salmonella infection and splenic infarction
10) Confidence 0.22 Published 2010 Journal Malar J Section Body Doc Link PMC2984568 Disease Relevance 1.35 Pain Relevance 0.39
Effects of antithrombin on monocytes and thrombocytes
Gene_expression (Effects) of antithrombin in monocytes
11) Confidence 0.19 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.65 Pain Relevance 0.06
Protein C levels and antithrombin III levels were both determined by commercially available kits using chromogenic substrates (STA-STACHROM®; Diagnostica Stago, Asnieres, France).
Gene_expression (levels) of antithrombin III
12) Confidence 0.19 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.22 Pain Relevance 0
Thrombin generation proceeds via the (extrinsic) tissue factor/factor VIIa route concomitant with depression of inhibitory mechanisms of thrombin generation, such as antithrombin III and the protein C system.
Gene_expression (generation) of antithrombin associated with depression
13) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1750988 Disease Relevance 0.83 Pain Relevance 0.18
An increased frequency of Factor V Leiden, antithrombin deficiency and the prothrombin (G20210A) gene mutation have not been consistently identified [1].
Gene_expression (deficiency) of antithrombin
14) Confidence 0.06 Published 2008 Journal Thromb J Section Body Doc Link PMC2330027 Disease Relevance 1.88 Pain Relevance 0.11

General Comments

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