INT67608

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 41
Total Number 41
Disease Relevance 25.09
Pain Relevance 19.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
neurons 4
astrocytes 4
brain 2
fat 2
lipid droplets 2
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 158 100.00 Very High Very High Very High
agonist 92 100.00 Very High Very High Very High
Abeta 16 100.00 Very High Very High Very High
noradrenaline 80 99.92 Very High Very High Very High
intrathecal 1 99.84 Very High Very High Very High
COX2 6 99.80 Very High Very High Very High
cOX1 3 99.80 Very High Very High Very High
aspirin 4 99.74 Very High Very High Very High
qutenza 42 99.72 Very High Very High Very High
Dorsal horn 2 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 229 100.00 Very High Very High Very High
Cancer 102 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 12 99.84 Very High Very High Very High
Disease 107 99.54 Very High Very High Very High
Death 24 99.42 Very High Very High Very High
Breast Cancer 19 98.92 Very High Very High Very High
Apoptosis 84 98.88 Very High Very High Very High
Drug Induced Neurotoxicity 4 98.88 Very High Very High Very High
Aging 11 98.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.
Gene_expression (expression) of PPARgamma in astrocytes associated with noradrenaline
1) Confidence 0.78 Published 2003 Journal J. Neurochem. Section Title Doc Link 12887689 Disease Relevance 0.84 Pain Relevance 0.76
Conversely, decreased NA due to LC cell death in AD may reduce endogenous PPARgamma expression and therefore potentiate neuroinflammatory processes.
Gene_expression (expression) of PPARgamma associated with locus ceruleus, noradrenaline, disease and death
2) Confidence 0.78 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.71 Pain Relevance 0.73
Our results indicate for the first time that PPARgamma expression can be modulated by the cAMP signalling pathway, and suggest that the anti-inflammatory effects of NA on brain cells may be partly mediated by increasing PPARgamma levels.
Gene_expression (expression) of PPARgamma in brain associated with inflammation and noradrenaline
3) Confidence 0.78 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.75 Pain Relevance 0.86
Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.
Gene_expression (expression) of peroxisome proliferator activated receptor gamma in astrocytes associated with noradrenaline
4) Confidence 0.78 Published 2003 Journal J. Neurochem. Section Title Doc Link 12887689 Disease Relevance 0.84 Pain Relevance 0.75
To study a possible relationship between NA depletion and PPARgamma-mediated suppression of inflammation we investigated the influence of NA on PPARgamma expression in murine primary cortical astrocytes and neurons.
Gene_expression (expression) of PPARgamma in neurons associated with inflammation and noradrenaline
5) Confidence 0.78 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.90 Pain Relevance 0.87
Increased expression of PPARgamma, as well as ciglitazone and sulindac sulfide induced expression of E-cadherin, which has been linked to increased differentiation of NSCLC.
Gene_expression (expression) of PPARgamma associated with non-small-cell lung cancer
6) Confidence 0.70 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12391285 Disease Relevance 0.95 Pain Relevance 0.54
Overexpression of PPARgamma in NSCLC cells strongly inhibited the transformed growth properties of the cells, providing a molecular confirmation of the results obtained with the PPARgamma agonists.
Gene_expression (Overexpression) of PPARgamma associated with non-small-cell lung cancer and agonist
7) Confidence 0.70 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12391285 Disease Relevance 0.98 Pain Relevance 0.55
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Gene_expression (levels) of PPARgamma in neurons associated with noradrenaline
8) Confidence 0.68 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.84 Pain Relevance 0.90
Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.
Gene_expression (production) of PPARgamma in macrophages associated with necrosis, qutenza and cancer
9) Confidence 0.65 Published 2004 Journal FEBS Lett. Section Title Doc Link 15304360 Disease Relevance 0.55 Pain Relevance 1.26
Rheumatoid synovial cells expressed PPARgamma mRNA, and the PPARgamma ligands 15-deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone reduced the proliferation and induced apoptosis in synovial cells.
Gene_expression (expressed) of PPARgamma in synovial cells associated with apoptosis
10) Confidence 0.64 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12065695 Disease Relevance 0.92 Pain Relevance 0.64
between MMTV-PyV mice and the mice, generated by crossing PPARg+/?
Gene_expression (crossing) of PPARg
11) Confidence 0.62 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.15 Pain Relevance 0
To determine whether ibuprofen inhibits pro-amyloidogenic factors, APPsw (Tg2576) mice were treated with ibuprofen for 6 months, and expression levels of the Abeta and inflammation-related molecules alpha1 antichymotrypsin (ACT), apoE, BACE1, and peroxisome proliferator-activated receptor gamma) (PPARgamma) were measured.
Gene_expression (expression) of peroxisome proliferator-activated receptor gamma associated with inflammation and abeta
12) Confidence 0.60 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15688088 Disease Relevance 0.74 Pain Relevance 0.70
To determine whether ibuprofen inhibits pro-amyloidogenic factors, APPsw (Tg2576) mice were treated with ibuprofen for 6 months, and expression levels of the Abeta and inflammation-related molecules alpha1 antichymotrypsin (ACT), apoE, BACE1, and peroxisome proliferator-activated receptor gamma) (PPARgamma) were measured.
Gene_expression (expression) of PPARgamma associated with inflammation and abeta
13) Confidence 0.60 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15688088 Disease Relevance 0.75 Pain Relevance 0.71
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes containing para-trifluoromethyl (DIM-C-pPhCF(3)), t-butyl (DIM-C-pPhtBu), and phenyl (DIM-C-pPhC(6)H(5)) groups are methylene-substituted diindolylmetyhanes (C-DIMs) that activate peroxisome proliferator-activated receptor gamma (PPARgamma) in estrogen receptor alpha-negative MDA-MB-231 and MDA-MB-453 breast cancer cells.
Gene_expression (negative) of PPARgamma in MDA-MB-231 associated with breast cancer
14) Confidence 0.57 Published 2008 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 17624585 Disease Relevance 0.35 Pain Relevance 0.11
By using preadipocyte cultures, we found that evodiamine, but not capsaicin, increased phosphorylation of ERK/MAPK, reduced the expression of transcription factors such as peroxisome proliferator-activated receptor-gamma, and strongly inhibited adipocyte differentiation.
Gene_expression (expression) of peroxisome proliferator-activated receptor-gamma in adipocyte associated with qutenza
15) Confidence 0.54 Published 2008 Journal Endocrinology Section Abstract Doc Link 17884939 Disease Relevance 0.40 Pain Relevance 0.17
Pioglitazone is a thiazolidinedione (TZD) drug and an agonist of the peroxisome proliferator-activated receptor gamma (PPAR?)
Gene_expression (agonist) of peroxisome proliferator-activated receptor gamma associated with agonist
16) Confidence 0.46 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.99 Pain Relevance 0.36
Age-related loss of neuronal nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase-2 and PPAR gamma expression and is altered by long-term NS398 administration.
Gene_expression (expression) of PPAR gamma in hippocampus associated with aging, cox2 and hippocampus
17) Confidence 0.44 Published 2005 Journal J. Neurobiol. Section Title Doc Link 15551346 Disease Relevance 0.35 Pain Relevance 0.46
NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).
Gene_expression (basis) of PPARgamma associated with cinod
18) Confidence 0.42 Published 2008 Journal Eur J Med Chem Section Title Doc Link 18222570 Disease Relevance 0.19 Pain Relevance 0.29
Adipogenesis in stimulated 3T3-L1-preadipocytes was determined by oil red O-staining of intracellular lipid droplets, triglyceride levels, expression of peroxisome proliferator-activated receptor-gamma, and expression of fatty acid synthase.
Gene_expression (expression) of peroxisome proliferator-activated receptor-gamma in lipid droplets
19) Confidence 0.36 Published 2007 Journal Circ. Res. Section Abstract Doc Link 17347480 Disease Relevance 0.34 Pain Relevance 0.27
An extreme case of target selectivity is found for the peroxisome proliferator-activated receptor gamma (PPAR?)
Gene_expression (found) of peroxisome proliferator-activated receptor gamma
20) Confidence 0.34 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0.05

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