INT67609

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Context Info
Confidence 0.46
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 9.53
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
lung 2
Pparg (Mus musculus)
Pparg - P12A (4)
Pain Link Frequency Relevance Heat
cINOD 46 100.00 Very High Very High Very High
alcohol 10 100.00 Very High Very High Very High
Inflammation 89 99.70 Very High Very High Very High
Cannabinoid 6 99.44 Very High Very High Very High
Pain 6 98.38 Very High Very High Very High
peptic ulcer disease 2 97.60 Very High Very High Very High
agonist 16 96.68 Very High Very High Very High
COX2 8 94.36 High High
cannabis 3 91.08 High High
Analgesic 3 90.08 High High
Disease Link Frequency Relevance Heat
Ulcers 4 99.76 Very High Very High Very High
INFLAMMATION 125 99.70 Very High Very High Very High
Skin Cancer 13 99.44 Very High Very High Very High
Lung Cancer 14 99.28 Very High Very High Very High
Cancer 26 99.04 Very High Very High Very High
Infection 5 98.96 Very High Very High Very High
Nicotine Addiction 11 98.80 Very High Very High Very High
Breast Cancer 12 98.64 Very High Very High Very High
Stomach Cancer 1 98.36 Very High Very High Very High
Disease 25 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the association of Pro12Ala PPARgamma polymorphism and Helicobacter pylori infection with gastric cancer and peptic ulcer disease (PUD).
PPARgamma (P12A) Binding (association) of associated with peptic ulcer disease, ulcers, disease, stomach cancer and infection
1) Confidence 0.46 Published 2008 Journal Ann. Oncol. Section Abstract Doc Link 18372284 Disease Relevance 1.06 Pain Relevance 0.22
Here we report that AJA binds directly and specifically to the peroxisome proliferator-activated receptor gamma (PPARgamma), a pharmacologically important member of the nuclear receptor superfamily.
peroxisome proliferator-activated receptor gamma Binding (binds) of
2) Confidence 0.45 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12695526 Disease Relevance 0.33 Pain Relevance 0.38
Here we report that AJA binds directly and specifically to the peroxisome proliferator-activated receptor gamma (PPARgamma), a pharmacologically important member of the nuclear receptor superfamily.
PPARgamma Binding (binds) of
3) Confidence 0.45 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12695526 Disease Relevance 0.33 Pain Relevance 0.38
PPARgamma is bound and activated by fatty acid derivatives and prostaglandin J2.
PPARgamma Binding (bound) of
4) Confidence 0.44 Published 2000 Journal Br. J. Nutr. Section Abstract Doc Link 11242474 Disease Relevance 0.09 Pain Relevance 0.13
We propose that PPARgamma serves as a target for NSAIDs that accounts for COX-independent inhibition of lung cancer cell growth.
PPARgamma Binding (target) of in lung associated with lung cancer and cinod
5) Confidence 0.43 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12391285 Disease Relevance 0.69 Pain Relevance 0.43
PPARgamma is bound and activated by prostaglandin J2 and fatty acid derivatives, which are its natural ligands.
PPARgamma Binding (bound) of
6) Confidence 0.37 Published 1999 Journal Ann. Med. Section Abstract Doc Link 10574507 Disease Relevance 0.30 Pain Relevance 0.17
Recently, attention has been focused on the anti-proliferative activity of nonsteroidal anti-inflammatory drugs (NSAIDs) in cancerous or transformed cells, which is mediated through interaction with PPARgamma irrespective of their ability to inhibit COX-2.
PPARgamma Binding (interaction) of associated with inflammation and cinod
7) Confidence 0.36 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 14555212 Disease Relevance 0.96 Pain Relevance 0.50
Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid.
peroxisome proliferator-activated receptor gamma Binding (binding) of associated with cannabinoid
8) Confidence 0.33 Published 2003 Journal Mol. Pharmacol. Section Title Doc Link 12695526 Disease Relevance 0.31 Pain Relevance 0.38
We also observe interaction between NSAID, alcohol consumption and PPARgamma2 Pro12Ala genotype in relation to breast cancer risk.
PPARgamma2 (P12A) Binding (interaction) of associated with breast cancer, cinod and alcohol
9) Confidence 0.33 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 16959787 Disease Relevance 0.78 Pain Relevance 0.71
Since several NSAIDs bind to and activate the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) which acts to inhibit the expression of proinflammatory genes, this receptor appears a good candidate to mediate the observed anti-inflammatory effects.
PPARgamma Binding (bind) of associated with inflammation and cinod
10) Confidence 0.32 Published 2005 Journal Brain Section Abstract Doc Link 15817521 Disease Relevance 0.95 Pain Relevance 0.61
However, 15d-PGJ2 has not been correlated with painful sensations; rather, it is considered to mediate anti-inflammatory processes via binding to the nuclear peroxisome proliferator-activated receptor gamma (PPAR?).
peroxisome proliferator-activated receptor gamma Binding (binding) of associated with pain and inflammation
11) Confidence 0.25 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2515828 Disease Relevance 0.63 Pain Relevance 0.27
This paper describes molecular docking studies of a series of classical NSAIDs with PPARgamma receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been found to be responsible for some of the already established pharmacological effects observed for marketed drugs.
PPARgamma Binding (target) of associated with inflammation, cancer and cinod
12) Confidence 0.22 Published 2008 Journal Eur J Med Chem Section Abstract Doc Link 18222570 Disease Relevance 0.20 Pain Relevance 0.27
NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).
PPARgamma Binding (interactions) of associated with cinod
13) Confidence 0.22 Published 2008 Journal Eur J Med Chem Section Title Doc Link 18222570 Disease Relevance 0.19 Pain Relevance 0.29
There was interaction between IL-1B T-31C, COX-2 A-1195G and PPARgamma2 Pro(12)Ala and NSAID use in relation to lung cancer risk.
PPARgamma2 (P12A) Binding (interaction) of in lung associated with lung cancer and cinod
14) Confidence 0.21 Published 2008 Journal Mutat. Res. Section Abstract Doc Link 18164040 Disease Relevance 1.59 Pain Relevance 0.61
In this report, we show that indomethacin binds and activates peroxisome proliferator-activated receptor gamma (PPARgamma), a ligand-activated transcription factor known to play a pivotal role in adipogenesis.
PPARgamma Binding (binds) of
15) Confidence 0.18 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9013583 Disease Relevance 0.24 Pain Relevance 0.34
In addition to fatty acids, several synthetic compounds, such as fibrates and thiazolidinediones, bind and activate PPARalpha and PPARgamma, respectively.
PPARgamma Binding (bind) of
16) Confidence 0.07 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0 Pain Relevance 0
The polymorphisms IL6 G-174C, IL8 T-251A, PPARgamma2 Pro(12)Ala, IL1beta T-31C, and IL10 C-592A were not associated with risk of BCC.
PPARgamma2 (P12A) Binding (associated) of associated with skin cancer
17) Confidence 0.06 Published 2007 Journal Mutat. Res. Section Abstract Doc Link 17307204 Disease Relevance 0.89 Pain Relevance 0.36

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