INT6761

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 6
Speculated 4
Reported most in Abstract
Documents 100
Total Number 106
Disease Relevance 26.71
Pain Relevance 62.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
nerves 5
dorsal horn 3
plasma 2
spinal cord 2
trigeminal ganglia 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 7205 100.00 Very High Very High Very High
Neuropeptide 1095 100.00 Very High Very High Very High
antagonist 543 100.00 Very High Very High Very High
Migraine 232 100.00 Very High Very High Very High
headache 109 100.00 Very High Very High Very High
substance P 86 100.00 Very High Very High Very High
Somatostatin 28 100.00 Very High Very High Very High
Angina 9 99.84 Very High Very High Very High
lidocaine 9 99.80 Very High Very High Very High
Pain 99 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 238 100.00 Very High Very High Very High
Erectile Dysfunction 8 99.84 Very High Very High Very High
Angina 6 99.84 Very High Very High Very High
INFLAMMATION 65 99.72 Very High Very High Very High
Natriuresis 3 99.72 Very High Very High Very High
Gastroparesis 7 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 116 99.44 Very High Very High Very High
Pain 78 99.28 Very High Very High Very High
Neuroblastoma 35 99.24 Very High Very High Very High
Hyperalgesia 15 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High throughput screening led to the identification of (R)-Tyr-(S)-Lys dipeptide-like compounds that showed weak but unequivocal binding to the human CGRP receptor.
CGRP Binding (binding) of associated with calcitonin gene-related peptide
1) Confidence 0.48 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 16161996 Disease Relevance 0.32 Pain Relevance 1.49
It was found that HCEC specifically bound CGRP in a saturable manner with a Kd of 2.0 x 10-9 M.
CGRP Binding (bound) of in HCEC associated with calcitonin gene-related peptide
2) Confidence 0.47 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10754330 Disease Relevance 0.18 Pain Relevance 0.66
Because neutrophil infiltration of the clear corneal surface is a hallmark of corneal inflammation in the human eye, we determined whether CGRP can bind to human corneal epithelial cells (HCEC) and induce expression of the neutrophil chemotactic protein IL-8.
CGRP Binding (bind) of in eye associated with inflammation and calcitonin gene-related peptide
3) Confidence 0.47 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10754330 Disease Relevance 0.19 Pain Relevance 0.61
Additional residues deemed critical for hCGRP(1) receptor binding were identified from an alanine scan of [A(34),F(35)]CGRP(28-37)-NH(2) and included V(32) and F(37).
CGRP Binding (binding) of associated with calcitonin gene-related peptide
4) Confidence 0.47 Published 2001 Journal Biochemistry Section Abstract Doc Link 11444978 Disease Relevance 0.13 Pain Relevance 0.71
However, it also interacts with other CGRP-activated receptors, of unknown composition.
CGRP Binding (interacts) of
5) Confidence 0.46 Published 2005 Journal Cardiovasc Drug Rev Section Abstract Doc Link 15867946 Disease Relevance 0.09 Pain Relevance 0.29
Among those is olcegepant, which demonstrates extremely high affinity for human CGRP receptors, even higher affinity than the endogenous ligand [53].
CGRP Binding (affinity) of associated with calcitonin gene-related peptide
6) Confidence 0.45 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.37 Pain Relevance 1.14
Instead, it is postulated that the C-terminal phenylalaninamide of the ligand directly interacts with the mature CGRP receptor in order for this high affinity binding to occur.
CGRP Binding (interacts) of associated with calcitonin gene-related peptide
7) Confidence 0.43 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.49
Furthermore, the binding affinity of CGRP and related peptides is modulated by nucleotides such as GTP.
CGRP Binding (affinity) of
8) Confidence 0.42 Published 1997 Journal Neurosci Biobehav Rev Section Abstract Doc Link 9353797 Disease Relevance 0.21 Pain Relevance 0.07
No interaction between CGRP and SP or NKA was observed.
CGRP Neg (No) Binding (interaction) of associated with substance p and calcitonin gene-related peptide
9) Confidence 0.42 Published 1991 Journal Peptides Section Abstract Doc Link 1712469 Disease Relevance 0.78 Pain Relevance 1.10
Detection of CGRP was possible in these cells due to a binding of the antibody to CGRP that was itself bound to its cell surface receptor.
CGRP Binding (binding) of associated with calcitonin gene-related peptide
10) Confidence 0.42 Published 2004 Journal J Endod Section Abstract Doc Link 15085045 Disease Relevance 0.59 Pain Relevance 0.74
Because the changes in [125I]hCGRP binding did not parallel the hyperalgesia accompanying the unilateral adjuvant-induced inflammation, we believe that CGRP receptors are not directly involved with the hyperalgesia but may be involved with other plastic changes observed in the spinal cord during unilateral adjuvant-induced inflammation.
hCGRP Binding (binding) of in spinal cord associated with hyperalgesia, inflammation and spinal cord
11) Confidence 0.41 Published 1992 Journal Brain Res. Section Abstract Doc Link 1332803 Disease Relevance 1.01 Pain Relevance 0.94
Changes in [125I]hCGRP binding in rat spinal cord in an experimental model of acute, peripheral inflammation.

[125I]Human calcitonin gene-related peptide ([125I]hCGRP) binding in the dorsal horn of the spinal cord exhibited differential changes among laminae over time in response to unilateral adjuvant-induced inflammation.

hCGRP Binding (binding) of in spinal cord associated with inflammation, dorsal horn, calcitonin gene-related peptide and spinal cord
12) Confidence 0.41 Published 1992 Journal Brain Res. Section Title Doc Link 1332803 Disease Relevance 0.72 Pain Relevance 0.87
In tolerant animals, there was a marked increase in CGRP-like immunostaining and a decrease (30-45%) in [125I]human CGRP alpha binding in laminae I, II and III of the dorsal horn of the spinal cord.
CGRP Binding (binding) of in dorsal horn associated with dorsal horn, spinal cord and calcitonin gene-related peptide
13) Confidence 0.40 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7752094 Disease Relevance 0.07 Pain Relevance 1.63
For example, a purified CLR N-terminal domain overexpressed in E. coli was able to specifically bind 125I-CGRP and could displace this same radiolabeled peptide from a membrane preparation containing native CGRP receptors [25].
CGRP Binding (bind) of associated with calcitonin gene-related peptide
14) Confidence 0.38 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.32
Increasing concentrations of CGRP or the N-terminally acetylated peptide fragment, AcCGRP(19–37) were used to inhibit specific [125I-Tyr]CGRP(8–37) binding to membranes prepared from HEK293T-RAMP1 cells transiently transfected with wild type or mutant CLRs.
CGRP Binding (binding) of associated with calcitonin gene-related peptide
15) Confidence 0.38 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.40
Experiments were conducted by cumulatively adding calcitonin gene-related peptide (CGRP) or lidocaine to the organ baths.
calcitonin gene-related peptide Binding (adding) of associated with lidocaine and calcitonin gene-related peptide
16) Confidence 0.37 Published 1996 Journal J Reconstr Microsurg Section Abstract Doc Link 8723835 Disease Relevance 0.17 Pain Relevance 0.63
Experiments were conducted by cumulatively adding calcitonin gene-related peptide (CGRP) or lidocaine to the organ baths.
CGRP Binding (adding) of associated with lidocaine and calcitonin gene-related peptide
17) Confidence 0.37 Published 1996 Journal J Reconstr Microsurg Section Abstract Doc Link 8723835 Disease Relevance 0.17 Pain Relevance 0.63
There is a clear association between head pain and the release of calcitonin gene-related peptide (CGRP).
CGRP Spec (clear) Binding (association) of in head associated with headache and calcitonin gene-related peptide
18) Confidence 0.37 Published 2007 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 17845144 Disease Relevance 0.78 Pain Relevance 1.23
Acute ischemic chest pain is not associated with increased calcitonin gene-related peptide (CGRP) levels in peripheral plasma nor in the coronary circulation.
calcitonin gene-related peptide Binding (associated) of in plasma associated with angina and calcitonin gene-related peptide
19) Confidence 0.37 Published 1999 Journal Scand. Cardiovasc. J. Section Title Doc Link 10540919 Disease Relevance 0.94 Pain Relevance 0.91
Acute ischemic chest pain is not associated with increased calcitonin gene-related peptide (CGRP) levels in peripheral plasma nor in the coronary circulation.
CGRP Binding (associated) of in plasma associated with angina and calcitonin gene-related peptide
20) Confidence 0.37 Published 1999 Journal Scand. Cardiovasc. J. Section Title Doc Link 10540919 Disease Relevance 0.94 Pain Relevance 0.91

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