INT67610

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 53
Total Number 55
Disease Relevance 31.91
Pain Relevance 25.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
synovial cells 4
neurons 3
adipose tissue 3
astrocytes 3
SW480 1
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
noradrenaline 56 99.98 Very High Very High Very High
qutenza 55 99.98 Very High Very High Very High
agonist 47 99.92 Very High Very High Very High
cINOD 142 99.88 Very High Very High Very High
rheumatoid arthritis 14 99.64 Very High Very High Very High
Inflammation 209 99.54 Very High Very High Very High
Cannabinoid 14 99.44 Very High Very High Very High
aspirin 10 99.06 Very High Very High Very High
cytokine 45 98.80 Very High Very High Very High
Neuropathic pain 2 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 119 99.92 Very High Very High Very High
Apoptosis 62 99.68 Very High Very High Very High
Rheumatoid Arthritis 14 99.64 Very High Very High Very High
Colon Cancer 2 99.60 Very High Very High Very High
INFLAMMATION 292 99.54 Very High Very High Very High
Disease 122 99.50 Very High Very High Very High
Insulin Resistance 22 99.34 Very High Very High Very High
Alzheimer's Dementia 9 99.32 Very High Very High Very High
Aging 24 98.60 Very High Very High Very High
Hyperglycemia 12 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of astrocytes and neurons with 100 micro m NA resulted in an increase of PPARgamma mRNA as well as PPARgamma protein levels in both cell types.
Positive_regulation (increase) of PPARgamma in neurons associated with noradrenaline
1) Confidence 0.70 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.85 Pain Relevance 0.91
Our results indicate for the first time that PPARgamma expression can be modulated by the cAMP signalling pathway, and suggest that the anti-inflammatory effects of NA on brain cells may be partly mediated by increasing PPARgamma levels.
Positive_regulation (increasing) of PPARgamma in brain associated with inflammation and noradrenaline
2) Confidence 0.70 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.55 Pain Relevance 0.77
The effect of NSAIDs in Alzheimer's disease is probably mediated by activation of the peroxisome proliferator-activated receptor-gamma.
Positive_regulation (activation) of peroxisome proliferator-activated receptor-gamma associated with cinod and disease
3) Confidence 0.70 Published 2002 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 12448960 Disease Relevance 1.45 Pain Relevance 0.90
Additionally, these studies also suggest that inhibition of interleukin-2 is mediated by a PPARgamma, which is activated by a cyclooxygenase-2 metabolite of anandamide.
Positive_regulation (activated) of PPARgamma
4) Confidence 0.67 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.04
It has been postulated that some NSAIDs target pathological hallmarks of AD by interacting with several pathways, including the inhibition of cyclooxygenases (COX) and activation of the peroxisome proliferator-activated receptor gamma.
Positive_regulation (activation) of peroxisome proliferator-activated receptor gamma associated with cinod and disease
5) Confidence 0.67 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15485484 Disease Relevance 1.15 Pain Relevance 0.57
Our data demonstrate for the first time that the anti-inflammatory action of capsaicin may be mediated by PPARgamma activation in LPS-stimulated RAW 264.7 cells.
Positive_regulation (activation) of PPARgamma in RAW 264 associated with qutenza and inflammation
6) Confidence 0.67 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 15304360 Disease Relevance 0.48 Pain Relevance 1.16
Furthermore, the ability of NSAIDs and PPARgamma ligands to stimulate the activation of PPARgamma correlated with their ability to decrease cell viability(r = 0.92, p < 0.01) and ability to induce DNA fragmentation (r = 0.97, p < 0.001) in synovial cells.
Positive_regulation (activation) of PPARgamma in synovial cells associated with cinod
7) Confidence 0.66 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12065695 Disease Relevance 0.62 Pain Relevance 0.50
Luciferase reporter assay demonstrated that not only PPARgamma ligands but also NSAIDs, which could induce apoptosis, increased the activation of PPARgamma in synovial cells.
Positive_regulation (activation) of PPARgamma in synovial cells associated with cinod and apoptosis
8) Confidence 0.66 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12065695 Disease Relevance 0.75 Pain Relevance 0.53
These results suggest that PPARgamma is an attractive target for induction of apoptosis in rheumatoid synovial cells and that the activation of the PPARgamma pathway is associated with the apoptotic action of NSAIDs.
Positive_regulation (activation) of PPARgamma in synovial cells associated with cinod and apoptosis
9) Confidence 0.66 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12065695 Disease Relevance 0.70 Pain Relevance 0.43
In this study, we examined the effect of NSAIDs on the growth and apoptosis of synovial cells from patients with rheumatoid arthritis and analyzed the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) as a possible mechanism of action of NSAIDs.
Spec (analyzed) Positive_regulation (activation) of PPARgamma in synovial cells associated with rheumatoid arthritis, cinod and apoptosis
10) Confidence 0.66 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12065695 Disease Relevance 0.73 Pain Relevance 0.59
These studies also implicate other potential therapeutic actions of AJA through PPARgamma activation in multiple signaling pathways.
Positive_regulation (activation) of PPARgamma
11) Confidence 0.65 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12695526 Disease Relevance 0.32 Pain Relevance 0.20
Activation of PPARgamma by AJA requires the AF-2 helix of the receptor, suggesting that AJA activates PPARgamma through the ligand-dependent AF-2 function.
Positive_regulation (Activation) of PPARgamma
12) Confidence 0.65 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12695526 Disease Relevance 0.37 Pain Relevance 0.35
PPARgamma is bound and activated by fatty acid derivatives and prostaglandin J2.
Positive_regulation (activated) of PPARgamma
13) Confidence 0.64 Published 2000 Journal Br. J. Nutr. Section Abstract Doc Link 11242474 Disease Relevance 0.09 Pain Relevance 0.14
The action of capsaicin is associated with NF-kappaB inactivation and/or PPARgamma activation.
Positive_regulation (activation) of PPARgamma associated with qutenza
14) Confidence 0.64 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.13 Pain Relevance 0.69
Recent data in vitro suggested that NSAIDs negatively regulate microglial activation and immunostimulated amyloid precursor protein processing via PPARgamma activation.
Positive_regulation (activation) of PPARgamma associated with alzheimer's dementia and cinod
15) Confidence 0.63 Published 2005 Journal Brain Section Abstract Doc Link 15817521 Disease Relevance 0.92 Pain Relevance 0.74
Since several NSAIDs bind to and activate the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) which acts to inhibit the expression of proinflammatory genes, this receptor appears a good candidate to mediate the observed anti-inflammatory effects.
Positive_regulation (activate) of PPARgamma associated with inflammation and cinod
16) Confidence 0.63 Published 2005 Journal Brain Section Abstract Doc Link 15817521 Disease Relevance 0.95 Pain Relevance 0.61
PPARgamma is bound and activated by prostaglandin J2 and fatty acid derivatives, which are its natural ligands.
Positive_regulation (activated) of PPARgamma
17) Confidence 0.54 Published 1999 Journal Ann. Med. Section Abstract Doc Link 10574507 Disease Relevance 0.31 Pain Relevance 0.17
Recently, it has been shown that activation of PPARgamma by J(2) series cyclopentenone prostaglandins (cyPGs), especially 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) or synthetic agents, such as antidiabetic thiazolidinediones, causes anti-proliferation, apoptosis, differentiation, and anti-inflammation of certain types of cancer cells.
Positive_regulation (activation) of PPARgamma associated with inflammation, cancer and apoptosis
18) Confidence 0.52 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 14555212 Disease Relevance 1.03 Pain Relevance 0.15
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes containing p-trifluoromethyl, t-butyl, and phenyl [1,1-bis(3'-indolyl)-1-(p-phenyl)methane (DIM-C-pPhC(6)H(5))] substituents induce peroxisome proliferator-activated receptor gamma (PPARgamma)-mediated transactivation in SW480 colon cancer cells.
Positive_regulation (transactivation) of PPARgamma in SW480 associated with colon cancer
19) Confidence 0.50 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731770 Disease Relevance 0.31 Pain Relevance 0.08
Rosiglitazone (30 microM), AR-A014418 (1 microM), PG(J2) (10 microM), and NP031115 (1, 10 and 25 microM) activate PPARgamma in CHO transfected cells.
Positive_regulation (activate) of PPARgamma
20) Confidence 0.49 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18579278 Disease Relevance 0.13 Pain Relevance 0.35

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