INT67612

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 38
Total Number 42
Disease Relevance 22.67
Pain Relevance 8.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
plasma 1
muscle 1
colon 1
finger 1
epithelial cell 1
PPARG (Homo sapiens)
PPARG - P12A (2)
Pain Link Frequency Relevance Heat
agonist 86 100.00 Very High Very High Very High
diclofenac 16 100.00 Very High Very High Very High
cINOD 61 99.90 Very High Very High Very High
Cannabinoid 6 99.86 Very High Very High Very High
Dismenorea 2 99.76 Very High Very High Very High
qutenza 22 99.68 Very High Very High Very High
antagonist 19 99.32 Very High Very High Very High
endometriosis 2 99.24 Very High Very High Very High
Analgesic 6 98.78 Very High Very High Very High
Inflammation 63 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 256 100.00 Very High Very High Very High
Colorectal Cancer 18 99.84 Very High Very High Very High
Dysmenorrhea 2 99.76 Very High Very High Very High
Colon Cancer 256 99.70 Very High Very High Very High
Disease 100 99.64 Very High Very High Very High
Overweight 58 99.28 Very High Very High Very High
Death 44 99.26 Very High Very High Very High
Endometriosis (extended) 2 99.24 Very High Very High Very High
Diabetes Mellitus 348 99.12 Very High Very High Very High
Apoptosis 50 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent genome whole association studies failed to identify associations with PPARG SNPs [37–42].
PPARG Binding (associations) of
1) Confidence 0.48 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.57 Pain Relevance 0
The well-known PPARgamma ligands, troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) strongly induced PPARgamma binding activity.
PPARgamma Binding (activity) of
2) Confidence 0.48 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12711249 Disease Relevance 0.57 Pain Relevance 0.25
The ability of various eicosanoids to bind PPARgamma in colorectal carcinoma cells was investigated using luciferase reporter assays.
PPARgamma Binding (bind) of associated with colorectal cancer
3) Confidence 0.48 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12711249 Disease Relevance 0.55 Pain Relevance 0.07
Eligible for inclusion were all population-based cohort, case-control, or cross-sectional studies reporting on associations between the PPARG2 Pro12Ala variant and type 2 diabetes.
PPARG2 Binding (associations) of associated with diabetes mellitus
4) Confidence 0.48 Published 2010 Journal American Journal of Epidemiology Section Body Doc Link PMC2834889 Disease Relevance 0.36 Pain Relevance 0
The fact that non steroidal anti-inflammatory drugs (NSAIDs) delay the onset and reduce the risk to develop Alzheimer's disease, while they also bind to and activate PPARgamma, led to the hypothesis that one dimension of NSAID protection in AD may be mediated by PPARgamma.
PPARgamma Binding (bind) of associated with inflammation, cinod and disease
5) Confidence 0.48 Published 2007 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17569578 Disease Relevance 1.14 Pain Relevance 0.52
Biochemical studies indicate that AJA binds directly and selectively to the isotype gamma of the peroxisome proliferator-activated receptor (PPARgamma) suggesting that this may be a pharmacologically relevant receptor for this compound and a potential target for drug development in the treatment of pain and inflammation.
PPARgamma Binding (binds) of associated with pain and inflammation
6) Confidence 0.47 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17462987 Disease Relevance 0.28 Pain Relevance 0.40
ET-18-O-CH3 treatment resulted in elevated release of 15d-PGJ2 and DNA binding and transcriptional activity of PPARgamma.
PPARgamma Binding (binding) of
7) Confidence 0.46 Published 2005 Journal FEBS Lett. Section Abstract Doc Link 16253239 Disease Relevance 0.50 Pain Relevance 0.10
Although these compounds bind to PPARgamma transcription factors as agonists, emerging evidence suggests that TGZ acts independently of PPARgamma in many functions, including apoptosis.
PPARgamma Binding (bind) of associated with agonist and apoptosis
8) Confidence 0.45 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14662774 Disease Relevance 0.41 Pain Relevance 0.11
Unexpectedly, diclofenac bound PPARgamma at therapeutic concentrations (K(i) = 700 nM) but induced only 2-fold activation of PPARgamma at a concentration of 25 microM and antagonized PPARgamma trans-activation by rosiglitazone.
PPARgamma Binding (bound) of associated with diclofenac
9) Confidence 0.44 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11752200 Disease Relevance 0.24 Pain Relevance 0.81
PPARG SNPs may affect CHD risk through their association with cardiovascular risk factors.
PPARG Binding (association) of associated with coronary artery disease
10) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.66 Pain Relevance 0
This analysis suggests that DNA methylation is closely associated with repressive chromatin marks at the PPARG promoter to impair gene expression in CRC cells.


PPARG Binding (associated) of associated with colon cancer
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.28 Pain Relevance 0
On the basis of our data, it is tempting to speculate a possible intervention for the treatment of PPARG-negative CRCs, based on the combination of a conventional chemotherapy with epigenetic drugs and a specific PPAR?
PPARG Binding (intervention) of associated with colon cancer
12) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.46 Pain Relevance 0.13
The conventional NSAIDs that inhibit both cyclooxygenases (COX-1 and COX-2) also induced PPARgamma binding activity.
PPARgamma Binding (activity) of associated with cinod
13) Confidence 0.37 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12711249 Disease Relevance 0.47 Pain Relevance 0.45
Thiazolidinediones are highly specific ligands for PPARG and lead to the activation of the nuclear receptor on binding (52).
PPARG Binding (ligands) of
14) Confidence 0.37 Published 2010 Journal American Journal of Epidemiology Section Body Doc Link PMC2834889 Disease Relevance 0.70 Pain Relevance 0
We did not detect any somatic or germline mutations in PPARG to account for differential
PPARG Binding (account) of in germline
15) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2605846 Disease Relevance 0.93 Pain Relevance 0
Firstly, this might be explained by the gender-specific effect and the restrictive recessive genetic model of the PPARG association.
PPARG Binding (association) of
16) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.57 Pain Relevance 0
We found no consistent association for none of the 4 PPARG SNPs (C-681G, C-689T, Pro12Ala, and C1431T) in PRIME and ADVANCE.
PPARG Neg (no) Binding (association) of
17) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.47 Pain Relevance 0
Specific repressive chromatin marks and DNA methylation are associated with PPARG transcription
PPARG Binding (associated) of
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0 Pain Relevance 0.04
Larger studies are needed to validate these results, which suggest that the PPARgamma Pro12Ala polymorphism may interact with other factors to protect against colorectal adenoma.
PPARgamma (P12A) Binding (interact) of associated with adenoma
19) Confidence 0.36 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15564289 Disease Relevance 0.77 Pain Relevance 0.08
Indeed, most of the studies about nucleotide variations in PPARG have mainly focused on the association between a DNA variant and a specific phenotype (such as predictors of diabetes, obesity, and BMI) [57, 85–89] or related biochemical markers (plasma levels of hormones, peptides, or metabolites) demonstrated—or just supposed—to be transcriptionally regulated by PPAR?
PPARG Binding (association) of in plasma associated with diabetes mellitus and obesity
20) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.19 Pain Relevance 0

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