INT67613

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 94
Total Number 96
Disease Relevance 69.15
Pain Relevance 34.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
macrophages 4
plaque 3
colon 3
CGCs 2
neurons 2
PPARG (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 269 100.00 Very High Very High Very High
COX2 401 99.98 Very High Very High Very High
cytokine 55 99.98 Very High Very High Very High
agonist 121 99.92 Very High Very High Very High
adenocard 1 99.82 Very High Very High Very High
diclofenac 50 99.78 Very High Very High Very High
Inflammation 184 99.52 Very High Very High Very High
Multiple sclerosis 11 99.28 Very High Very High Very High
Abeta 21 99.04 Very High Very High Very High
qutenza 11 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 196 100.00 Very High Very High Very High
Metabolic Syndrome 38 99.96 Very High Very High Very High
Disease 295 99.92 Very High Very High Very High
Apoptosis 68 99.92 Very High Very High Very High
Demyelinating Disease 19 99.84 Very High Very High Very High
Nevus 76 99.76 Very High Very High Very High
Cirrhosis 6 99.72 Very High Very High Very High
Colon Cancer 185 99.60 Very High Very High Very High
Skin Cancer 303 99.52 Very High Very High Very High
INFLAMMATION 285 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding that activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) suppresses inflammation in peripheral macrophages and in models of human autoimmune disease instigated the evaluation of this salutary action for the treatment of CNS disorders with an inflammatory component.
Positive_regulation (activation) of peroxisome proliferator-activated receptor-gamma in macrophages associated with autoimmune disease and inflammation
1) Confidence 0.70 Published 2007 Journal Nature clinical practice. Neurology Section Abstract Doc Link 17805244 Disease Relevance 0.62 Pain Relevance 0.27
The finding that activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) suppresses inflammation in peripheral macrophages and in models of human autoimmune disease instigated the evaluation of this salutary action for the treatment of CNS disorders with an inflammatory component.
Positive_regulation (activation) of PPARgamma in macrophages associated with autoimmune disease and inflammation
2) Confidence 0.70 Published 2007 Journal Nature clinical practice. Neurology Section Abstract Doc Link 17805244 Disease Relevance 0.63 Pain Relevance 0.27
The verification of these findings in human cells prompted the initiation of clinical studies evaluating PPARgamma activation in patients with multiple sclerosis.
Positive_regulation (activation) of PPARgamma associated with multiple sclerosis
3) Confidence 0.70 Published 2007 Journal Nature clinical practice. Neurology Section Abstract Doc Link 17805244 Disease Relevance 0.89 Pain Relevance 0.35
Finally, activation of PPARgamma has been found to be protective in several models of multiple sclerosis.
Positive_regulation (activation) of PPARgamma associated with multiple sclerosis
4) Confidence 0.70 Published 2007 Journal Nature clinical practice. Neurology Section Abstract Doc Link 17805244 Disease Relevance 0.99 Pain Relevance 0.40
In summary, indomethacin (>100 microM) directly activates PPARgamma in human colorectal cancer cells.
Positive_regulation (activates) of PPARgamma associated with colon cancer
5) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12606626 Disease Relevance 0.74 Pain Relevance 0.13
However, PPARgamma activation does not underlie the antineoplastic activity of indomethacin on human colorectal cancer cells in vitro.
Positive_regulation (activation) of PPARgamma associated with colon cancer
6) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12606626 Disease Relevance 0.67 Pain Relevance 0.13
Indomethacin directly activated PPARgamma in both cell lines (HCT116 > SW480).
Positive_regulation (activated) of PPARgamma in SW480
7) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12606626 Disease Relevance 0.74 Pain Relevance 0.15
Activation of peroxisome proliferator-activated receptor gamma does not explain the antiproliferative activity of the nonsteroidal anti-inflammatory drug indomethacin on human colorectal cancer cells.
Positive_regulation (Activation) of peroxisome proliferator-activated receptor gamma associated with inflammation, colon cancer and cinod
8) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12606626 Disease Relevance 0.72 Pain Relevance 0.19
PPARG transcriptional activation, on the other hand, appears to be modulated by the zinc-finger protein (ZAC) likely together with other still unknown factors [23].
Positive_regulation (activation) of PPARG in finger
9) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.41 Pain Relevance 0
The ability of various nonsteroidal anti-inflammatory drugs (NSAIDs) to induce PPARgamma activation was also evaluated.
Positive_regulation (activation) of PPARgamma associated with inflammation and cinod
10) Confidence 0.70 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12711249 Disease Relevance 0.50 Pain Relevance 0.45
The activation of peroxisome proliferator activated receptor gamma (PPARgamma) may play a role in the control of colorectal carcinogenesis.
Positive_regulation (activation) of PPARgamma
11) Confidence 0.70 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12711249 Disease Relevance 0.46 Pain Relevance 0.07
In general, however, neither COX-1- nor COX-2-specific inhibitors induced the activation of PPARgamma.
Positive_regulation (activation) of PPARgamma
12) Confidence 0.70 Published 2003 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12711249 Disease Relevance 0.39 Pain Relevance 0.44
The finding that activation of PPARs, and in particular, the PPARgamma isoform, suppresses inflammation in peripherial macrophages and in models of human autoimmune disease, instigated the experimental evaluation of these salutary actions for several CNS disorders that have an inflammatory component.
Positive_regulation (activation) of PPARgamma in macrophages associated with autoimmune disease and inflammation
13) Confidence 0.69 Published 2007 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17569578 Disease Relevance 0.52 Pain Relevance 0.12
The verification of these findings in human cells prompted the initiation of clinical studies evaluating PPARgamma activation in Multiple Sclerosis patients.
Positive_regulation (activation) of PPARgamma associated with demyelinating disease
14) Confidence 0.69 Published 2007 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17569578 Disease Relevance 0.99 Pain Relevance 0.36
Future directions for analgesic research are many, but include the use of nitric oxide (NO) NSAIDs; the possibility of decreasing NO in the central nervous system; inhibiting the vanilloid receptor-1; inhibiting adenosine kinase; activating PPARgamma; and mimicking superoxide dismutase, as well as combinations of complementary-acting analgesics.
Positive_regulation (activating) of PPARgamma in central nervous system associated with adenocard, analgesic, cinod and central nervous system
15) Confidence 0.69 Published 2001 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 11695256 Disease Relevance 0.77 Pain Relevance 1.29
These drugs also activated peroxisome proliferator-activated receptor gamma (PPARgamma) at concentration ranges that increase TFF2 expression, and upregulated TFF2 expression was suppressed by GW9662, a specific inhibitor of PPARgamma.
Positive_regulation (activated) of peroxisome proliferator-activated receptor gamma
16) Confidence 0.67 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14759512 Disease Relevance 0 Pain Relevance 0.30
NSAIDs activate the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma); however, a potent agonist of this receptor, pioglitazone, only modestly reduced SDS-soluble Abeta levels and did not affect amyloid plaque burden or microglia activation, indicating that PPARgamma activation is not involved in the Abeta lowering effect of NSAIDs.
Positive_regulation (activate) of peroxisome proliferator-activated receptor gamma in plaque associated with agonist, cinod, amyloid plaque and abeta
17) Confidence 0.67 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930788 Disease Relevance 1.01 Pain Relevance 0.76
Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells.
Positive_regulation (activation) of peroxisome proliferator-activated receptor gamma in HT-29 associated with qutenza, colon cancer and apoptosis
18) Confidence 0.67 Published 2004 Journal J Med Food Section Title Doc Link 15383218 Disease Relevance 1.14 Pain Relevance 0.60
NSAIDs activate the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma); however, a potent agonist of this receptor, pioglitazone, only modestly reduced SDS-soluble Abeta levels and did not affect amyloid plaque burden or microglia activation, indicating that PPARgamma activation is not involved in the Abeta lowering effect of NSAIDs.
Positive_regulation (activation) of PPARgamma in plaque associated with agonist, cinod, amyloid plaque and abeta
19) Confidence 0.67 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930788 Disease Relevance 0.80 Pain Relevance 0.75
In this report, we show that indomethacin binds and activates peroxisome proliferator-activated receptor gamma (PPARgamma), a ligand-activated transcription factor known to play a pivotal role in adipogenesis.
Positive_regulation (activates) of peroxisome proliferator-activated receptor gamma
20) Confidence 0.67 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9013583 Disease Relevance 0.24 Pain Relevance 0.34

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