INT67614

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 8
Speculated 8
Reported most in Body
Documents 438
Total Number 450
Disease Relevance 293.28
Pain Relevance 63.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
liver 7
hepatocytes 5
skeletal muscle 4
platelet 3
lung 3
PPARA (Homo sapiens)
PPARA - V290M (1)
Pain Link Frequency Relevance Heat
agonist 6020 100.00 Very High Very High Very High
Inflammatory mediators 146 100.00 Very High Very High Very High
Inflammation 4323 99.98 Very High Very High Very High
cINOD 1009 99.96 Very High Very High Very High
Inflammatory response 485 99.92 Very High Very High Very High
Endocannabinoid 171 99.68 Very High Very High Very High
Osteoarthritis 285 99.44 Very High Very High Very High
Multiple sclerosis 304 99.40 Very High Very High Very High
COX-2 inhibitor 207 99.36 Very High Very High Very High
cytokine 785 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 7645 100.00 Very High Very High Very High
INFLAMMATION 5209 100.00 Very High Very High Very High
Diabetes Mellitus 3424 100.00 Very High Very High Very High
Obesity 4773 99.92 Very High Very High Very High
Colon Cancer 2347 99.92 Very High Very High Very High
Insulin Resistance 453 99.92 Very High Very High Very High
Necrosis 269 99.92 Very High Very High Very High
Stress 643 99.90 Very High Very High Very High
Hypoxia 336 99.90 Very High Very High Very High
Cancer 10843 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
that the causal events are activation of PPAR?
Positive_regulation (activation) of PPAR
1) Confidence 0.68 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.96 Pain Relevance 0.03
An increased PPAR?
Positive_regulation (increased) of PPAR
2) Confidence 0.68 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.10 Pain Relevance 0
On the contrary, other studies have shown that activation of PPAR?
Positive_regulation (activation) of PPAR
3) Confidence 0.68 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.22 Pain Relevance 0
Endogenous ligand activation of PPAR?
Positive_regulation (activation) of PPAR
4) Confidence 0.68 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.15 Pain Relevance 0.08
Specifically, it has been shown that activated PPAR?
Positive_regulation (activated) of PPAR
5) Confidence 0.68 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.56 Pain Relevance 0.23
In contrast, activation of PPAR?
Positive_regulation (activation) of PPAR
6) Confidence 0.68 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.20 Pain Relevance 0.04
Activation of PPAR?
Positive_regulation (Activation) of PPAR
7) Confidence 0.68 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.14 Pain Relevance 0.08
Finally, recent data indicate that activated PPAR?
Positive_regulation (activated) of PPAR
8) Confidence 0.68 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.41 Pain Relevance 0.13
Insulin resistance and diabetes mellitus cause a shift of myocardial energy metabolism away from glucose and toward increased reliance on fatty acids that is driven in part by activation of PPAR?
Positive_regulation (activation) of PPAR associated with diabetes mellitus and insulin resistance
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 1.36 Pain Relevance 0.11
Fenofibric acid derivatives exert their primary effects on lipid metabolism via the activation of peroxisome proliferator-activated receptor-alpha (PPAR-?)
Positive_regulation (activation) of PPAR
10) Confidence 0.67 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.08 Pain Relevance 0.08
Finally, we show that the same NSAIDs that activate PPARgamma are also efficacious activators of PPARalpha, a liver-enriched PPAR subtype that plays a key role in peroxisome proliferation.
Positive_regulation (activators) of PPAR in liver associated with cinod
11) Confidence 0.67 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9013583 Disease Relevance 0.22 Pain Relevance 0.44
Activation of peroxisome proliferator-activated receptor-alpha (PPAR-?)
Positive_regulation (Activation) of PPAR
12) Confidence 0.67 Published 2010 Journal Experimental Diabetes Research Section Abstract Doc Link PMC3014714 Disease Relevance 0.86 Pain Relevance 0.14
In our study, FF did not affect serum total Hcy levels in the diabetic group, whereas it increased total Hcy levels in the control group probably through PPAR-?
Positive_regulation (increased) of PPAR associated with diabetes mellitus
13) Confidence 0.67 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014714 Disease Relevance 0.85 Pain Relevance 0
However, direct activation of PPAR-?
Positive_regulation (activation) of PPAR
14) Confidence 0.67 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014714 Disease Relevance 0.70 Pain Relevance 0.03
regulates the activity of iNOS and activation of this PPAR
Positive_regulation (activation) of PPAR
15) Confidence 0.67 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.96 Pain Relevance 0.56
It is postulated that activation of PPAR?
Spec (postulated) Positive_regulation (activation) of PPAR
16) Confidence 0.67 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.83 Pain Relevance 0.60
On

the other hand, the activation of PPAR?

Positive_regulation (activation) of PPAR
17) Confidence 0.66 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.80 Pain Relevance 0.08
Activation of PPAR?
Positive_regulation (Activation) of PPAR
18) Confidence 0.66 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 1.94 Pain Relevance 0
membranes suggests that they could activate PPAR, induce PPAR binding to PPRE,
Positive_regulation (activate) of PPAR
19) Confidence 0.66 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0
activate PPAR?
Positive_regulation (activate) of PPAR
20) Confidence 0.66 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0

General Comments

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