INT67618

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.77
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Inpp5k) endoplasmic reticulum (Inpp5k) plasma membrane (Inpp5k)
nucleus (Inpp5k) cytoplasm (Inpp5k)
Anatomy Link Frequency
spinal cord 1
Inpp5k (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 24 99.98 Very High Very High Very High
Central grey 3 99.68 Very High Very High Very High
Spinal cord 2 99.20 Very High Very High Very High
Antinociceptive 9 99.12 Very High Very High Very High
cINOD 1 96.76 Very High Very High Very High
narcan 2 95.56 Very High Very High Very High
antinociception 4 94.44 High High
intrathecal 1 76.24 Quite High
Intracerebroventricular 1 75.28 Quite High
tail-flick 1 66.56 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 99.68 Very High Very High Very High
INFLAMMATION 1 96.52 Very High Very High Very High
Cancer 3 75.00 Quite High
Skin Cancer 2 68.16 Quite High
Liver Cancer 2 66.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of specific subtypes of serine/threonine protein phosphatases (PPs) plays a role in the antinociceptive effect of acute morphine, but it is not known whether these enzymes are involved in morphine-induced antinociception in morphine-tolerant animals.
Spec (whether) Positive_regulation (activation) of PPs associated with antinociception, antinociceptive and morphine
1) Confidence 0.45 Published 2007 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17234262 Disease Relevance 0 Pain Relevance 1.10
Thus, PPs regulate prostaglandin metabolism via both positive (COX-2 induction) and inhibitory mechanisms.
Positive_regulation (induction) of PPs
2) Confidence 0.40 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9013627 Disease Relevance 0.48 Pain Relevance 0.12
Subcutaneously administered morphine increased activity of OA-sensitive PPs in the PAG and the spinal cord in a dose-dependent manner; this was prevented by concurrent administration of naloxone.
Positive_regulation (increased) of PPs in spinal cord associated with narcan, central grey, spinal cord and morphine
3) Confidence 0.30 Published 2005 Journal Brain Res. Section Abstract Doc Link 16102737 Disease Relevance 0.29 Pain Relevance 1.42

General Comments

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