INT6762

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Context Info
Confidence 0.31
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 56
Total Number 62
Disease Relevance 6.62
Pain Relevance 30.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 4
stomach 4
brain 3
NG108-15 2
spleen 2
Srms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fortral 84 100.00 Very High Very High Very High
opiate 67 100.00 Very High Very High Very High
Opioid 40 100.00 Very High Very High Very High
narcan 38 100.00 Very High Very High Very High
Enkephalin 34 100.00 Very High Very High Very High
mu opioid receptor 4 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
B1 receptor 582 99.98 Very High Very High Very High
antagonist 152 99.98 Very High Very High Very High
agonist 128 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 4 99.76 Very High Very High Very High
Burns 3 99.56 Very High Very High Very High
Neuroblastoma 2 99.44 Very High Very High Very High
Diabetes Mellitus 390 99.08 Very High Very High Very High
Glioma 2 98.64 Very High Very High Very High
Pain 75 98.48 Very High Very High Very High
Pheochromocytoma 2 96.96 Very High Very High Very High
Nervous System Injury 24 94.40 High High
Ganglion Cysts 6 93.24 High High
Neuropathic Pain 384 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither a single injection of imipramine (10 mg/kg i.p.) nor addition of imipramine or fluoxetine into the binding assay medium mimicked the changes in the maximal binding of brain sigma sites induced by chronic treatment with these drugs.
sites Binding (binding) of in brain associated with fluoxetine
1) Confidence 0.31 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8359206 Disease Relevance 0 Pain Relevance 0.49
Repeated treatment with imipramine (10 mg/kg intraperitoneally (i.p.), once daily for 14 days) caused a decrease in the Bmax, without affecting the Kd, of [3H]DTG (1,3-di-o-tolylguanidine) binding to the haloperidol-sensitive sigma sites in the striatum, hippocampus and cerebral cortex of the rat.
sites Binding (binding) of in cerebral cortex associated with hippocampus and cerebral cortex
2) Confidence 0.31 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8359206 Disease Relevance 0 Pain Relevance 0.40
Identification and characterization of two sigma-like binding sites in the mouse neuroblastoma x rat glioma hybrid cell line NG108-15.
sites Binding (binding) of in NG108-15 associated with neuroblastoma and glioma
3) Confidence 0.28 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1658298 Disease Relevance 0.25 Pain Relevance 0.16
Thus, sigma binding sites in NG108-15 cells seem to correspond to recently detected sigma sites in a pheochromocytoma cell line (PC12). [3H]-1-(2-thienyl)-cyclohexyl]piperidine ([3H]TCP), a PCP receptor-selective ligand binds to NG108-15 cells with moderate affinity (Kd = 139 nM; maximal number of binding sites = 4.7 pmol/mg of protein).
sites Binding (binding) of in NG108-15 associated with pheochromocytoma
4) Confidence 0.28 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1658298 Disease Relevance 0.25 Pain Relevance 0.15
Haloperidol, a 'typical' neuroleptic, with affinity for both dopamine (DA) receptors and sigma binding sites, exacerbates morphine withdrawal in guinea-pigs.
sites Binding (affinity) of associated with dopamine, withdrawal and morphine
5) Confidence 0.19 Published 1993 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8097127 Disease Relevance 0 Pain Relevance 0.60
The use of paraffin-impregnated gauze for burns and skin graft donor sites is commonly associated with wound adherence with consequent pain and trauma upon removal.
sites Binding (associated) of in skin associated with pain, burns and injury
6) Confidence 0.19 Published 2009 Journal Int Wound J Section Abstract Doc Link 19719526 Disease Relevance 0.61 Pain Relevance 0.10
In this study, the effects of sigma ligands (+)- and (-)-SKF 10,047 (1 and 10 mg/kg s.c.), pentazocine (20 mg/kg s.c.) and DTG (1 and 10 mg/kg s.c.), non-competitive NMDA antagonists ketamine hydrochloride (20 mg/kg s.c.) and MK-801 (0.025, 0.1 and 1 mg/kg s.c.), 'atypical' neuroleptic drugs with (remoxipride 25 mg/kg s.c.) and without (raclopride 10 mg/kg s.c.; clozapine 25 mg/kg s.c.) affinity for sigma sites, and atropine sulphate (20 mg/kg s.c.), were investigated on the opiate withdrawal response induced by naloxone hydrochloride (15 mg/kg s.c.) in guinea-pigs treated 2 h before with a single dose of morphine sulphate (15 mg/kg s.c.). (+)- and (-)-SKF 10,047, pentazocine, ketamine and MK-801, given 0.5 h before naloxone, significantly attenuated the increased locomotor activity and other behaviours associated with morphine withdrawal in guinea-pigs.
sites Binding (affinity) of associated with eae, narcan, morphine, fortral, ketamine, antagonist, opiate and withdrawal
7) Confidence 0.19 Published 1993 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8097127 Disease Relevance 0 Pain Relevance 1.13
We have recently demonstrated that [3H]ohmefentanyl, a non-peptidergic opioid ligand which was suggested to cross the blood brain barrier in contrast to other peptidergic opioid ligands, bound not only to mu opioid receptor sites but also to sigma sites.
sites Binding (bound) of in blood associated with mu opioid receptor and opioid
8) Confidence 0.17 Published 1992 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1332831 Disease Relevance 0 Pain Relevance 0.40
We have recently demonstrated that [3H]ohmefentanyl, a non-peptidergic opioid ligand which was suggested to cross the blood brain barrier in contrast to other peptidergic opioid ligands, bound not only to mu opioid receptor sites but also to sigma sites.
sites Binding (bound) of in blood associated with mu opioid receptor and opioid
9) Confidence 0.17 Published 1992 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1332831 Disease Relevance 0 Pain Relevance 0.40
However, at high doses, DTG selectively suppressed the potentiation induced by a low dose of DTG and reduced the NMDA response below base line, presumably due to its low affinity for phencyclidine sites. 2-APHB, a structural analog of DTG devoid of affinity for sigma sites, had no effect on the NMDA response.
sites Binding (affinity) of
10) Confidence 0.17 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1532832 Disease Relevance 0 Pain Relevance 0.24
Spiperone, a butyrophenone with very low affinity for sigma sites, was ineffective in this paradigm.
sites Binding (affinity) of
11) Confidence 0.16 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1532832 Disease Relevance 0 Pain Relevance 0.21
The binding of [3H]-D-Ala2MePhe4Glyol enkephalin (3H-DAGO) to mu opioid sites was increased in many brain regions after chronic administration (7 days) of a low dose of naloxone (0.5 mg/kg/hr).
sites Binding (binding) of in brain associated with narcan, enkephalin and opioid
12) Confidence 0.15 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2846828 Disease Relevance 0 Pain Relevance 0.63
In contrast, after administration of a higher dose of naloxone (3.0 mg/kg/hr), the binding to mu, delta and kappa sites was increased in many brain areas, suggesting that up-regulation is observed only when a sufficient proportion of the receptors in vivo are occupied by the antagonist.
sites Binding (binding) of in brain associated with antagonist and narcan
13) Confidence 0.15 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2846828 Disease Relevance 0.07 Pain Relevance 0.83
Our data provide evidence that the rat stomach is endowed with sigma2 sites and I2 binding sites in addition to the previously identified non-I1/non-I2 [3H]clonidine binding sites.
sites Binding (binding) of in stomach associated with clonidine
14) Confidence 0.12 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9536007 Disease Relevance 0 Pain Relevance 0.35
Our data provide evidence that the rat stomach is endowed with sigma2 sites and I2 binding sites in addition to the previously identified non-I1/non-I2 [3H]clonidine binding sites.
sites Binding (binding) of in stomach associated with clonidine
15) Confidence 0.12 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9536007 Disease Relevance 0 Pain Relevance 0.35
Repeated treatment with imipramine (10 mg/kg intraperitoneally (i.p.), once daily for 14 days) caused a decrease in the Bmax, without affecting the Kd, of [3H]DTG (1,3-di-o-tolylguanidine) binding to the haloperidol-sensitive sigma sites in the striatum, hippocampus and cerebral cortex of the rat.
sites Binding (binding) of in hippocampus associated with hippocampus and cerebral cortex
16) Confidence 0.10 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8359206 Disease Relevance 0 Pain Relevance 0.40
Repeated treatment with imipramine (10 mg/kg intraperitoneally (i.p.), once daily for 14 days) caused a decrease in the Bmax, without affecting the Kd, of [3H]DTG (1,3-di-o-tolylguanidine) binding to the haloperidol-sensitive sigma sites in the striatum, hippocampus and cerebral cortex of the rat.
sites Binding (binding) of in striatum associated with hippocampus and cerebral cortex
17) Confidence 0.10 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8359206 Disease Relevance 0 Pain Relevance 0.40
Characterization of I2 imidazoline and sigma binding sites in the rat and human stomach.
sites Binding (Characterization) of in stomach
18) Confidence 0.09 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9536007 Disease Relevance 0 Pain Relevance 0.11
In rat stomach, binding of the radioligands was inhibited by imidazolines and by nonimidazoline sigma-site ligands, respectively, at different rank orders of affinity, which suggests the existence of I2-imidazoline binding sites as well as sigma2-sites.
sites Binding (binding) of in stomach
19) Confidence 0.09 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9536007 Disease Relevance 0 Pain Relevance 0.15
The present studies were undertaken to evaluate whether different types of opiate agonists interact in a distinguishable manner with mu, delta and kappa opiate binding sites.
sites Spec (whether) Binding (interact) of associated with agonist and opiate
20) Confidence 0.08 Published 1982 Journal Life Sci. Section Abstract Doc Link 6128658 Disease Relevance 0 Pain Relevance 0.72

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