INT67620

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2011
Negated 3
Speculated 2
Reported most in Abstract
Documents 53
Total Number 55
Disease Relevance 22.45
Pain Relevance 28.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 20
brain 16
neurons 8
hypothalamus 3
neocortex 3
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 542 100.00 Very High Very High Very High
Hippocampus 355 100.00 Very High Very High Very High
Pain 153 100.00 Very High Very High Very High
IPN 13 99.84 Very High Very High Very High
fluoxetine 222 99.78 Very High Very High Very High
Neuronal excitability 1 99.76 Very High Very High Very High
antidepressant 610 99.62 Very High Very High Very High
analgesia 5 99.62 Very High Very High Very High
Nerve growth factor 20 99.56 Very High Very High Very High
Glutamate 49 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 245 100.00 Very High Very High Very High
Pain 176 100.00 Very High Very High Very High
Urological Neuroanatomy 31 100.00 Very High Very High Very High
Inflammatory Pain 13 99.84 Very High Very High Very High
Depression 788 98.88 Very High Very High Very High
Opiate Addiction 3 98.88 Very High Very High Very High
Ganglion Cysts 26 98.80 Very High Very High Very High
Suicidal Behaviour 26 98.80 Very High Very High Very High
Neurodegenerative Disease 95 98.64 Very High Very High Very High
Aids-related Complex 129 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results demonstrate that BDNF gene expression in certain brain structures is inhibited by inflammatory pain, yet estrogen may enhance central nervous system sensitization associated with sensory processing.
Negative_regulation (inhibited) of Gene_expression (expression) of BDNF gene in brain structures associated with ipn and central nervous system
1) Confidence 0.59 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 0.90 Pain Relevance 0.69
These results suggest that up- and down-regulation of BDNF gene expression in distinct subgroups of rat DRG neurons are caused by damage to the peripheral nerve.
Negative_regulation (regulation) of Gene_expression (expression) of BDNF gene in peripheral nerve associated with dorsal root ganglion
2) Confidence 0.59 Published 1999 Journal Neuroreport Section Abstract Doc Link 10619644 Disease Relevance 0.34 Pain Relevance 0.44
CONCLUSION: The expression of BDNF and PSD-95 in hippocampal CA1 decreases in morphine-depended rats withdrawn for 1 week.
Negative_regulation (decreases) of Gene_expression (expression) of BDNF
3) Confidence 0.58 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18630696 Disease Relevance 0.07 Pain Relevance 0
Results showed that either stress or pain down-regulates expression of both NK-1 receptor and BDNF genes in the hippocampus.
Negative_regulation (regulates) of Gene_expression (expression) of BDNF in hippocampus associated with stress, pain and hippocampus
4) Confidence 0.58 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964488 Disease Relevance 1.31 Pain Relevance 0.84
RESULTS: L5 spinal nerve transection induced mechanical allodynia and depression, and decreased the function of learning and memory as well as the expression of brain-derived neurotrophic factor.
Negative_regulation (decreased) of Gene_expression (expression) of brain-derived neurotrophic factor in brain
5) Confidence 0.51 Published 2010 Journal Eur J Anaesthesiol Section Body Doc Link 19915478 Disease Relevance 0.15 Pain Relevance 0
CONCLUSIONS: We found that neuropathic pain may impair cognitive function via downregulation of the expression of brain-derived neurotrophic factor of the hippocampus, and amitriptyline rather than lornoxicam can ameliorate cognitive dysfunction via upregulation of brain-derived neurotrophic factor of the hippocampus.


Negative_regulation (downregulation) of Gene_expression (expression) of brain-derived neurotrophic factor in hippocampus
6) Confidence 0.51 Published 2010 Journal Eur J Anaesthesiol Section Body Doc Link 19915478 Disease Relevance 0.12 Pain Relevance 0
The methoxamine-stimulated BDNF synthesis was inhibited by desensitizing pretreatment with TPA, indicating that the alpha1-stimulation was mediated via PKC activation.
Negative_regulation (inhibited) of Gene_expression (synthesis) of BDNF
7) Confidence 0.50 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17681645 Disease Relevance 0 Pain Relevance 0.53
In animal models, acute and chronic immobilisation stress resulted in decreased BDNF expression using mRNA assays.
Negative_regulation (decreased) of Gene_expression (expression) of BDNF associated with stress
8) Confidence 0.49 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 1.04 Pain Relevance 0.51
In the SNL group, expression of BDNF in the L4 (P < 0.05) and L5 (P < 0.01) superficial dorsal horn was significantly decreased compared to that in the sham group.
Negative_regulation (decreased) of Gene_expression (expression) of BDNF in dorsal horn
9) Confidence 0.47 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17377110 Disease Relevance 0 Pain Relevance 0
Decreased levels of BDNF in response to stress could lead to a loss of normal plasticity and also to damage and death of neurons.
Negative_regulation (Decreased) of Gene_expression (levels) of BDNF in neurons associated with stress and death
10) Confidence 0.45 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906869 Disease Relevance 0.83 Pain Relevance 0.36
Conversely, although imipramine did not provide significant behavioral analgesia, it significantly blocked both pain- and stress-evoked alterations in hippocampal and spinal NK-1 and BDNF gene expression.
Negative_regulation (blocked) of Gene_expression (expression) of BDNF gene in spinal associated with stress, pain and analgesia
11) Confidence 0.43 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16956981 Disease Relevance 1.28 Pain Relevance 1.61
BDNF gene expression in these neurons was down-regulated after application of capsaicin to the sciatic nerve.
Negative_regulation (down-regulated) of Gene_expression (expression) of BDNF gene in sciatic nerve associated with qutenza and sciatic nerve
12) Confidence 0.43 Published 1999 Journal Neuroreport Section Abstract Doc Link 10619644 Disease Relevance 0.28 Pain Relevance 0.46
Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat.
Negative_regulation (stress-evoked) of Gene_expression (expression) of brain-derived neurotrophic factor in brain associated with stress, pain, antidepressant and analgesic
13) Confidence 0.43 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16956981 Disease Relevance 1.28 Pain Relevance 1.60
We examined the expression profiles of these novel BDNF transcripts in bilateral L4/5 DRGs in an L5-selective spinal nerve ligation (SSNL) model and bilateral L5 DRGs in a complete Freund's adjuvant (CFA) model of rats.
Spec (examined) Negative_regulation (profiles) of Spec (examined) Gene_expression (expression) of BDNF in spinal nerve associated with spinal nerve ligature
14) Confidence 0.43 Published 2008 Journal Brain Res. Section Abstract Doc Link 18353280 Disease Relevance 0.47 Pain Relevance 0.50
RESULTS: The expression of BDNF and PSD-95 in hippocampal CA1 decreased in the withdrawn group with morphine dependence for 1 week as compared with that in normal saline (NS) group (P < 0.01), and it increased in the withdrawn group with morphine dependence for 2 weeks as compared with that in morphine-dependent group for 1 week (P < 0.05) but still decreased as compared with that in NS group (P < 0.01), and it decreased in the withdrawn group with morphine dependence for 4 weeks as compared with the other three groups (P < 0.01).
Negative_regulation (decreased) of Gene_expression (expression) of BDNF
15) Confidence 0.42 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18630696 Disease Relevance 0.09 Pain Relevance 0
We analyzed only a small number of rat brains to examine BDNF and synaptophysin expression in the whole cerebral hemisphere.
Spec (examine) Negative_regulation (examine) of Spec (examine) Gene_expression (expression) of BDNF in cerebral hemisphere
16) Confidence 0.42 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.18 Pain Relevance 0.14
Hippocampal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression is decreased in rat models of pain and stress.
Negative_regulation (decreased) of Gene_expression (expression) of brain-derived neurotrophic factor gene in brain associated with stress and pain
17) Confidence 0.42 Published 2005 Journal Neuroscience Section Title Doc Link 15964488 Disease Relevance 0.90 Pain Relevance 0.78
The present study was designed to evaluate the expression of BDNF and NT-3 in the context of opiate dependence and withdrawal in PGi.
Negative_regulation (evaluate) of Gene_expression (expression) of BDNF associated with addiction, opiate, withdrawal and bdmf
18) Confidence 0.42 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.26 Pain Relevance 1.65
An opposite effect was observed in the hippocampus, where CFA down-regulated NK-1 receptor and BDNF gene expression, phenomena previously observed in immobilization models of stress and depression.
Negative_regulation (regulated) of Gene_expression (expression) of BDNF in hippocampus associated with stress, depression and hippocampus
19) Confidence 0.41 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2174921 Disease Relevance 0.85 Pain Relevance 0.89
An opposite effect was observed in the hippocampus, where CFA down-regulated NK-1 receptor and BDNF gene expression, phenomena previously observed in immobilization models of stress and depression.
Negative_regulation (down) of Gene_expression (expression) of BDNF in hippocampus associated with stress, depression and hippocampus
20) Confidence 0.41 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2174921 Disease Relevance 0.85 Pain Relevance 0.89

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