INT67621

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.71
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
neocortex 3
hippocampal formation 1
brain 1
hippocampus 1
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 40 100.00 Very High Very High Very High
Glutamate 9 99.40 Very High Very High Very High
antidepressant 44 97.60 Very High Very High Very High
Spinal cord 8 96.00 Very High Very High Very High
depression 6 95.88 Very High Very High Very High
long-term potentiation 68 90.68 High High
antagonist 4 86.72 High High
gABA 2 85.80 High High
agonist 3 73.88 Quite High
cytokine 6 67.32 Quite High
Disease Link Frequency Relevance Heat
Stress 10 99.80 Very High Very High Very High
Infarction 1 99.78 Very High Very High Very High
Diabetes Mellitus 93 99.68 Very High Very High Very High
Spinal Cord Injury 6 96.48 Very High Very High Very High
Injury 6 95.96 Very High Very High Very High
Depression 6 95.88 Very High Very High Very High
Myocardial Infarction 71 91.04 High High
Aids-related Complex 28 87.60 High High
Fibrosis 16 67.04 Quite High
Cv Unclassified Under Development 7 50.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthesis of the neurotrophic factor brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus have been proposed to be influenced by endogenous glutamate.
Negative_regulation (influenced) of in brain Gene_expression (Synthesis) of TrkB in hippocampus associated with glutamate and hippocampus
1) Confidence 0.41 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.38
It is possible that a diminished availability of full-length TrkB and an enhanced expression of truncated TrkB receptors in the injured cord could play an important role in reducing the effect of BDNF following injury.
Negative_regulation (diminished) of Gene_expression (expression) of TrkB associated with injury
2) Confidence 0.38 Published 2007 Journal J. Neurotrauma Section Abstract Doc Link 17376001 Disease Relevance 0.41 Pain Relevance 0.33
It is possible that a diminished availability of full-length TrkB and an enhanced expression of truncated TrkB receptors in the injured cord could play an important role in reducing the effect of BDNF following injury.
Negative_regulation (diminished) of Gene_expression (expression) of TrkB associated with injury
3) Confidence 0.38 Published 2007 Journal J. Neurotrauma Section Abstract Doc Link 17376001 Disease Relevance 0.41 Pain Relevance 0.33
Rodent studies suggest that stress exposure reduces BDNF expression and TrkB signaling in the hippocampal formation and neocortex, while antidepressant treatment increases TrkB signaling and counteracts the behavioral effects of stress [16–20].
Negative_regulation (reduces) of Gene_expression (expression) of TrkB in neocortex associated with stress and antidepressant
4) Confidence 0.17 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.61 Pain Relevance 0.66
Rodent studies suggest that stress exposure reduces BDNF expression and TrkB signaling in the hippocampal formation and neocortex, while antidepressant treatment increases TrkB signaling and counteracts the behavioral effects of stress [16–20].
Negative_regulation (reduces) of in hippocampal formation Gene_expression (expression) of TrkB in neocortex associated with stress and antidepressant
5) Confidence 0.06 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.61 Pain Relevance 0.66
However, this infarction-triggered expression of the angiogenic growth factors seemed to be impaired in the diabetic animals (DLZMI, Fig. 1B and C).
Negative_regulation (impaired) of Gene_expression (expression) of factors associated with diabetes mellitus and infarction
6) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.62 Pain Relevance 0.06
From this one can speculate that the complex process of revascularization in ischemic tissue is improved by the number of soluble factors present in the EPC-CM, which are presumably able to target simultaneously multiple cell types.
Negative_regulation (number) of Gene_expression (present) of factors
7) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.05 Pain Relevance 0.09

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