INT67624

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 1997
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 4.15
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Phex) endoplasmic reticulum (Phex)
Anatomy Link Frequency
fibroblast 2
brain 1
skin 1
Phex (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 5 99.92 Very High Very High Very High
Dynorphin 10 99.84 Very High Very High Very High
Enkephalin 11 99.46 Very High Very High Very High
Pain 3 90.36 High High
Bile 1 86.44 High High
Morphine 1 84.16 Quite High
transdermal 1 77.76 Quite High
narcan 2 75.28 Quite High
cerebral cortex 1 75.00 Quite High
Potency 1 48.08 Quite Low
Disease Link Frequency Relevance Heat
Rickets 18 99.62 Very High Very High Very High
Malignant Neoplastic Disease 6 99.56 Very High Very High Very High
Neurilemmoma 6 99.16 Very High Very High Very High
Paraneoplastic Syndromes 3 97.36 Very High Very High Very High
Hypophosphatemia 3 94.84 High High
Cancer 6 94.08 High High
Autosomal Disorder 3 91.00 High High
Pain 3 90.36 High High
Fatigue 3 90.12 High High
Muscle Weakness 3 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HMS-97 cells might be useful for further studies that aim to determine the genetic mechanism that leads to the observed PHEX and FGF-23 expression, both of which might have a direct role in the pathogenesis of oncogenic osteomalacia.
Gene_expression (expression) of PHEX associated with rickets
1) Confidence 0.26 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.24 Pain Relevance 0.06
A case of neuroendocrine oncogenic osteomalacia associated with a PHEX and fibroblast growth factor-23 expressing sinusidal malignant schwannoma.
Gene_expression (expressing) of PHEX in fibroblast associated with malignant neoplastic disease, rickets and neurilemmoma
2) Confidence 0.26 Published 2001 Journal Bone Section Title Doc Link 11595624 Disease Relevance 1.47 Pain Relevance 0.09
The cell line did express PHEX (phosphate-regulating gene with homologies to endopeptidases located on the X-chromosome) and FGF-23 (fibroblast growth factor-23) transcripts on northern hybridization; however, none of the known mutations from the related mendelian disorders of X-linked hypophosphatemic rickets or autosomal-dominant hypophosphatemic rickets could be detected.
Gene_expression (express) of PHEX in fibroblast associated with autosomal disorder and rickets
3) Confidence 0.18 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.43 Pain Relevance 0.09
Rat brain cortical cells in primary culture were used to investigate long-term effects of opiates on endopeptidases acting on dynorphin peptides.
Gene_expression (acting) of endopeptidases in brain associated with dynorphin and opiate
4) Confidence 0.05 Published 1997 Journal Brain Res. Section Abstract Doc Link 9237522 Disease Relevance 0 Pain Relevance 0.98
From the inhibitory study using specific inhibitors, it was clarified that enkephalin and elcatonin were mainly hydrolyzed by aminopeptidases, endopeptidases and serine proteases in the viable skin.
Gene_expression (hydrolyzed) of endopeptidases in skin associated with enkephalin
5) Confidence 0.02 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9013807 Disease Relevance 0 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox