INT67624

Context Info Confidence 0.26 First Reported 1997 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 5 Disease Relevance 4.15 Pain Relevance 1.67

Golgi apparatus (Phex) endoplasmic reticulum (Phex)

Anatomy Link Frequency fibroblast 2 brain 1 skin 1 Phex (Rattus norvegicus)

Pain Link Frequency Relevance Heat opiate 5 99.92 Dynorphin 10 99.84 Enkephalin 11 99.46 Pain 3 90.36 Bile 1 86.44 Morphine 1 84.16 transdermal 1 77.76 narcan 2 75.28 cerebral cortex 1 75.00 Potency 1 48.08

Disease Link Frequency Relevance Heat Rickets 18 99.62 Malignant Neoplastic Disease 6 99.56 Neurilemmoma 6 99.16 Paraneoplastic Syndromes 3 97.36 Hypophosphatemia 3 94.84 Cancer 6 94.08 Autosomal Disorder 3 91.00 Pain 3 90.36 Fatigue 3 90.12 Muscle Weakness 3 89.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HMS-97 cells might be useful for further studies that aim to determine the genetic mechanism that leads to the observed PHEX and FGF-23 expression, both of which might have a direct role in the pathogenesis of oncogenic osteomalacia.

Gene_expression (expression) of PHEX associated with rickets

1) Confidence 0.26 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.24 Pain Relevance 0.06

A case of neuroendocrine oncogenic osteomalacia associated with a PHEX and fibroblast growth factor-23 expressing sinusidal malignant schwannoma.

Gene_expression (expressing) of PHEX in fibroblast associated with malignant neoplastic disease, rickets and neurilemmoma

2) Confidence 0.26 Published 2001 Journal Bone Section Title Doc Link 11595624 Disease Relevance 1.47 Pain Relevance 0.09

The cell line did express PHEX (phosphate-regulating gene with homologies to endopeptidases located on the X-chromosome) and FGF-23 (fibroblast growth factor-23) transcripts on northern hybridization; however, none of the known mutations from the related mendelian disorders of X-linked hypophosphatemic rickets or autosomal-dominant hypophosphatemic rickets could be detected.

Gene_expression (express) of PHEX in fibroblast associated with autosomal disorder and rickets

3) Confidence 0.18 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.43 Pain Relevance 0.09

Rat brain cortical cells in primary culture were used to investigate long-term effects of opiates on endopeptidases acting on dynorphin peptides.

Gene_expression (acting) of endopeptidases in brain associated with dynorphin and opiate

4) Confidence 0.05 Published 1997 Journal Brain Res. Section Abstract Doc Link 9237522 Disease Relevance 0 Pain Relevance 0.98

From the inhibitory study using specific inhibitors, it was clarified that enkephalin and elcatonin were mainly hydrolyzed by aminopeptidases, endopeptidases and serine proteases in the viable skin.

Gene_expression (hydrolyzed) of endopeptidases in skin associated with enkephalin

5) Confidence 0.02 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9013807 Disease Relevance 0 Pain Relevance 0.45

General Comments

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