INT67635

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Context Info
Confidence 0.04
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 11.40
Pain Relevance 6.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnas) endosome (Gnas) signal transduction (Gnas)
extracellular region (Gnas) plasma membrane (Gnas) GTPase activity (Gnas)
Anatomy Link Frequency
macrophages 1
cochlea 1
P19 1
retina 1
spinal cord 1
Gnas (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 30 100.00 Very High Very High Very High
depression 39 99.84 Very High Very High Very High
Spinal cord 10 99.82 Very High Very High Very High
analgesia 10 99.54 Very High Very High Very High
Morphine 13 99.48 Very High Very High Very High
opioid receptor 8 98.84 Very High Very High Very High
mu opioid receptor 2 97.80 Very High Very High Very High
Calcium channel 20 97.40 Very High Very High Very High
agonist 28 96.24 Very High Very High Very High
Opioid 2 94.64 High High
Disease Link Frequency Relevance Heat
Repression 645 100.00 Very High Very High Very High
Targeted Disruption 255 100.00 Very High Very High Very High
Depression 39 99.84 Very High Very High Very High
Colon Cancer 10 96.12 Very High Very High Very High
Autism 5 95.92 Very High Very High Very High
INFLAMMATION 114 94.16 High High
Polyps 4 91.12 High High
Epilepsy 6 90.48 High High
Headache 3 90.16 High High
Death 11 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A homozygous CGRP-/- mouse line was generated by the targeted disruption of exon 5 in the calcitonin/alphaCGRP gene using homologous recombination.
Negative_regulation (disruption) of exon associated with targeted disruption
1) Confidence 0.04 Published 1999 Journal Neuroreport Section Abstract Doc Link 10208559 Disease Relevance 0.10 Pain Relevance 0.47
Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.
Negative_regulation (lacking) of Exon in spinal cord associated with opioid receptor and spinal cord
2) Confidence 0.03 Published 2003 Journal J. Pharmacol. Sci. Section Title Doc Link 14737012 Disease Relevance 0.15 Pain Relevance 1.02
In vitro studies in embryonic stem cells demonstrated that deletion of exon 8 ablated PDC activity.
Negative_regulation (deletion) of exon in embryonic stem cells
3) Confidence 0.03 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11708858 Disease Relevance 0.17 Pain Relevance 0.08
Differential downregulation of protein kinase C isoforms in spreading depression.
Negative_regulation (downregulation) of isoforms associated with kinase c and depression
4) Confidence 0.01 Published 1996 Journal Neurosci. Lett. Section Title Doc Link 9014175 Disease Relevance 1.02 Pain Relevance 0.79
We recently reported that an aberrant, alternatively spliced CAPS2 mRNA that lacks exon 3 (CAPS2?
Negative_regulation (lacks) of exon
5) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1853102 Disease Relevance 0.10 Pain Relevance 0
We examined this question in knockout mice containing disruptions of either the first or second coding exon of MOR-1.
Negative_regulation (disruptions) of exon associated with targeted disruption
6) Confidence 0.01 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10195199 Disease Relevance 0.10 Pain Relevance 0.81
Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1.
Negative_regulation (lacking) of exon associated with analgesia and morphine
7) Confidence 0.01 Published 1999 Journal Nat. Neurosci. Section Title Doc Link 10195199 Disease Relevance 0.09 Pain Relevance 0.86
In mutagenesis analyses, we identify two types of CaRRE motifs required for repression of NR1 E21 and demonstrate that either of these CaRRE motifs can be sufficient to confer CaMK IV–dependent repression on a heterologous exon.
Negative_regulation (repression) of exon associated with repression
8) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.43 Pain Relevance 0
Recently, two exonic UAGG elements and one downstream intronic G tract were identified as important for the splicing repression of this exon [20].
Negative_regulation (repression) of exon associated with repression
9) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.49 Pain Relevance 0
Thus, the reduced exon repression observed in LS6 and LS7 mutants is presumably due to the loss of this element.
Negative_regulation (repression) of exon associated with repression
10) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.48 Pain Relevance 0
We previously showed that the repression of the BK channel STREX exon after depolarization requires calcium ion influx through L-type calcium channels and a downstream Ca++/calmodulin-dependent protein kinase (CaMK) [23].
Negative_regulation (repression) of exon associated with calcium channel and repression
11) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.16 Pain Relevance 0.05
Thus a CaRRE 1–like element presumably also mediates the repression of this exon.
Negative_regulation (repression) of exon associated with repression
12) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.39 Pain Relevance 0
We showed previously that the splicing repression of the BK channel STREX exon is mediated by a CaRRE (CACAUNRUUAU) located in the 3?
Negative_regulation (repression) of exon associated with repression
13) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.38 Pain Relevance 0
Similar to two copies of CaRRE 1, one copy of each silencer element led to the complete repression of the exon (Figure 4C, lanes 1–4).
Negative_regulation (repression) of exon associated with repression
14) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.34 Pain Relevance 0
For Adcyap1r1 exon 14, no CaRRE was found in our motif search, but the exon was seen to be repressed by depolarization in differentiated P19 cells.
Negative_regulation (repressed) of exon in P19
15) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.34 Pain Relevance 0
These results indicate that CaMK IV–mediated exon repression requires multiple elements, and that there are two critical elements separate from the UAGG and G track motifs.


Negative_regulation (repression) of exon associated with repression
16) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.50 Pain Relevance 0
The coordinate downregulation of multiple PKC isoforms may be important in the functional depression of neuronal activity in SD.
Negative_regulation (downregulation) of isoforms in neuronal associated with kinase c and depression
17) Confidence 0.01 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014175 Disease Relevance 1.19 Pain Relevance 1.01
We observed a downregulation of the conventional (alpha, beta I, beta II, gamma) and the novel (delta, epsilon, eta) PKC isoforms in SD, but no change in the atypical isozyme (zeta).
Negative_regulation (downregulation) of isoforms associated with kinase c and depression
18) Confidence 0.01 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014175 Disease Relevance 1.19 Pain Relevance 0.99
Progeny were screened for Cre-mediated loss of exon 2 by PCR with a primer 5' to the 5' loxP site and 3' to the 3' loxP site of the Conditional Allele.
Negative_regulation (loss) of exon
19) Confidence 0.01 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.41 Pain Relevance 0
Since exons 2 and 3 are in different protein reading frames, no functional proteins should be generated from transcripts lacking exon 2.
Negative_regulation (lacking) of exon
20) Confidence 0.01 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.68 Pain Relevance 0

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