INT67636

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.08
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DYT10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 8 100.00 Very High Very High Very High
depression 13 99.64 Very High Very High Very High
antidepressant 1 97.90 Very High Very High Very High
cocaine 1 97.50 Very High Very High Very High
Migraine 1 90.20 High High
Catecholamine 1 88.08 High High
imagery 1 87.04 High High
Serotonin 5 83.12 Quite High
Enkephalin 1 80.48 Quite High
5HT 1 66.08 Quite High
Disease Link Frequency Relevance Heat
Depression 13 99.64 Very High Very High Very High
Osteoporosis 4 96.88 Very High Very High Very High
Cancer 7 93.28 High High
Headache 1 90.20 High High
Epilepsy 2 89.72 High High
Metastasis 2 69.44 Quite High
Hypercalcemia 1 65.36 Quite High
Pain 1 64.76 Quite High
Disease 1 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the underlying pathophysiological molecular mechanisms of SD, we analyzed the regulation of eight protein kinase C (PKC) isoforms by immunoblot during SD induced by a high-intensity stimulus of synaptic afferents in the CA1 region of hippocampal slices.
Spec (analyzed) Regulation (regulation) of PKC associated with kinase c and depression
1) Confidence 0.60 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014175 Disease Relevance 0.92 Pain Relevance 0.73
Using these methods, Na-dependent, NE+-induced hNET currents that are blocked by cocaine and antidepressants, channel modes of NE+ conduction, voltage-dependent uptake coupled to NE+-induced ion channel activity, PKC (phosphokinase C) regulation of NE+ uptake, and transporter modulation by [Ca2+]i have all been discovered.
Regulation (regulation) of PKC associated with antidepressant and cocaine
2) Confidence 0.60 Published 2001 Journal Mol. Membr. Biol. Section Abstract Doc Link 11396611 Disease Relevance 0.06 Pain Relevance 0.47
Signal transduction studies revealed that regulation of OPN was dependent on both protein kinase C (PKC) and the mitogen-activated protein (MAP) kinase cascade.
Regulation (regulation) of PKC associated with kinase c
3) Confidence 0.26 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10861858 Disease Relevance 1.10 Pain Relevance 0.11

General Comments

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