INT67636

Context Info Confidence 0.60 First Reported 1996 Last Reported 2001 Negated 0 Speculated 1 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 2.08 Pain Relevance 1.31

DYT10 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 8 100.00 depression 13 99.64 antidepressant 1 97.90 cocaine 1 97.50 Migraine 1 90.20 Catecholamine 1 88.08 imagery 1 87.04 Serotonin 5 83.12 Enkephalin 1 80.48 5HT 1 66.08

Disease Link Frequency Relevance Heat Depression 13 99.64 Osteoporosis 4 96.88 Cancer 7 93.28 Headache 1 90.20 Epilepsy 2 89.72 Metastasis 2 69.44 Hypercalcemia 1 65.36 Pain 1 64.76 Disease 1 57.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To examine the underlying pathophysiological molecular mechanisms of SD, we analyzed the regulation of eight protein kinase C (PKC) isoforms by immunoblot during SD induced by a high-intensity stimulus of synaptic afferents in the CA1 region of hippocampal slices.

Spec (analyzed) Regulation (regulation) of PKC associated with kinase c and depression

1) Confidence 0.60 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014175 Disease Relevance 0.92 Pain Relevance 0.73

Using these methods, Na-dependent, NE+-induced hNET currents that are blocked by cocaine and antidepressants, channel modes of NE+ conduction, voltage-dependent uptake coupled to NE+-induced ion channel activity, PKC (phosphokinase C) regulation of NE+ uptake, and transporter modulation by [Ca2+]i have all been discovered.

Regulation (regulation) of PKC associated with antidepressant and cocaine

2) Confidence 0.60 Published 2001 Journal Mol. Membr. Biol. Section Abstract Doc Link 11396611 Disease Relevance 0.06 Pain Relevance 0.47

Signal transduction studies revealed that regulation of OPN was dependent on both protein kinase C (PKC) and the mitogen-activated protein (MAP) kinase cascade.

Regulation (regulation) of PKC associated with kinase c

3) Confidence 0.26 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10861858 Disease Relevance 1.10 Pain Relevance 0.11

General Comments

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