INT6764

Context Info Confidence 0.45 First Reported 1982 Last Reported 1998 Negated 1 Speculated 2 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 0.58 Pain Relevance 5.28

plasma membrane (Oprl1) signal transducer activity (Oprl1)

Anatomy Link Frequency striatum 2 Oprl1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opiate 22 100.00 antagonist 7 100.00 Kappa opioid receptor 6 100.00 Antinociceptive 2 100.00 agonist 16 99.96 Morphine 12 99.08 orphanin 7 97.88 Analgesic 1 97.12 halothane 2 95.60 ketamine 2 95.08

Disease Link Frequency Relevance Heat Bordatella Infection 3 100.00 Ganglion Cysts 3 92.52 Stupor 1 90.96 Nociception 3 86.96 Drug Dependence 1 5.00 Hypoxia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This study does not support a role for opiate receptor regulation of the duration of sleeping time.

Regulation (role) of Regulation (regulation) of opiate receptor associated with opiate

1) Confidence 0.45 Published 1982 Journal Anesthesiology Section Abstract Doc Link 6121523 Disease Relevance 0.09 Pain Relevance 0.80

To investigate whether these effects are mediated via GTP-binding G(i/o) proteins we examined the influence of pertussis toxin on the effects of the kappa-opioid receptor agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benz eneacetamide (U-50,488) methanesulphonate and on the as yet undescribed effects of the opioid peptide dynorphin A (1-8) on contraction.

Spec (examined) Regulation (influence) of Regulation (effects) of kappa-opioid receptor associated with bordatella infection, dynorphin, agonist, kappa opioid receptor and opioid

2) Confidence 0.39 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9774224 Disease Relevance 0.23 Pain Relevance 0.44

The results also suggest that postreceptor components are important in regulating the kappa receptor function following prolonged opiate exposure.

Regulation (important) of Regulation (regulating) of kappa receptor associated with opiate

3) Confidence 0.26 Published 1990 Journal Brain Res. Section Abstract Doc Link 2165432 Disease Relevance 0.17 Pain Relevance 1.11

The present study explores developmental changes in mu- and kappa-opiate receptor control of PRL secretion.

Regulation (changes) of Regulation (control) of kappa-opiate receptor associated with opiate

4) Confidence 0.17 Published 1992 Journal Endocrinology Section Abstract Doc Link 1332851 Disease Relevance 0 Pain Relevance 0.53

Repeated and chronic morphine administration causes differential long-lasting changes in dopaminergic neurotransmission in rat striatum without changing its delta- and kappa-opioid receptor regulation.

Neg (without) Regulation (changing) of Regulation (regulation) of kappa-opioid receptor in striatum associated with analgesic, kappa opioid receptor and morphine

5) Confidence 0.14 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7908881 Disease Relevance 0 Pain Relevance 1.15

The present study examined the effects of the competitive NMDA antagonist, NPC 12626, on the antinociceptive effects of the specific kappa-opiate receptor agonist, U69,593, and the pronociceptive effects of orphanin FQ in an invertebrate system, the land snail, Cepaea nemoralis.

Spec (examined) Regulation (effects) of Regulation (effects) of kappa-opiate receptor associated with orphanin, antagonist, agonist, opiate and antinociceptive

6) Confidence 0.06 Published 1997 Journal Peptides Section Abstract Doc Link 9357050 Disease Relevance 0.09 Pain Relevance 1.26

General Comments

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