INT6764

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 1998
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.58
Pain Relevance 5.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
striatum 2
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 22 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
Kappa opioid receptor 6 100.00 Very High Very High Very High
Antinociceptive 2 100.00 Very High Very High Very High
agonist 16 99.96 Very High Very High Very High
Morphine 12 99.08 Very High Very High Very High
orphanin 7 97.88 Very High Very High Very High
Analgesic 1 97.12 Very High Very High Very High
halothane 2 95.60 Very High Very High Very High
ketamine 2 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 3 100.00 Very High Very High Very High
Ganglion Cysts 3 92.52 High High
Stupor 1 90.96 High High
Nociception 3 86.96 High High
Drug Dependence 1 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study does not support a role for opiate receptor regulation of the duration of sleeping time.
Regulation (role) of Regulation (regulation) of opiate receptor associated with opiate
1) Confidence 0.45 Published 1982 Journal Anesthesiology Section Abstract Doc Link 6121523 Disease Relevance 0.09 Pain Relevance 0.80
To investigate whether these effects are mediated via GTP-binding G(i/o) proteins we examined the influence of pertussis toxin on the effects of the kappa-opioid receptor agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benz eneacetamide (U-50,488) methanesulphonate and on the as yet undescribed effects of the opioid peptide dynorphin A (1-8) on contraction.
Spec (examined) Regulation (influence) of Regulation (effects) of kappa-opioid receptor associated with bordatella infection, dynorphin, agonist, kappa opioid receptor and opioid
2) Confidence 0.39 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9774224 Disease Relevance 0.23 Pain Relevance 0.44
The results also suggest that postreceptor components are important in regulating the kappa receptor function following prolonged opiate exposure.
Regulation (important) of Regulation (regulating) of kappa receptor associated with opiate
3) Confidence 0.26 Published 1990 Journal Brain Res. Section Abstract Doc Link 2165432 Disease Relevance 0.17 Pain Relevance 1.11
The present study explores developmental changes in mu- and kappa-opiate receptor control of PRL secretion.
Regulation (changes) of Regulation (control) of kappa-opiate receptor associated with opiate
4) Confidence 0.17 Published 1992 Journal Endocrinology Section Abstract Doc Link 1332851 Disease Relevance 0 Pain Relevance 0.53
Repeated and chronic morphine administration causes differential long-lasting changes in dopaminergic neurotransmission in rat striatum without changing its delta- and kappa-opioid receptor regulation.
Neg (without) Regulation (changing) of Regulation (regulation) of kappa-opioid receptor in striatum associated with analgesic, kappa opioid receptor and morphine
5) Confidence 0.14 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7908881 Disease Relevance 0 Pain Relevance 1.15
The present study examined the effects of the competitive NMDA antagonist, NPC 12626, on the antinociceptive effects of the specific kappa-opiate receptor agonist, U69,593, and the pronociceptive effects of orphanin FQ in an invertebrate system, the land snail, Cepaea nemoralis.
Spec (examined) Regulation (effects) of Regulation (effects) of kappa-opiate receptor associated with orphanin, antagonist, agonist, opiate and antinociceptive
6) Confidence 0.06 Published 1997 Journal Peptides Section Abstract Doc Link 9357050 Disease Relevance 0.09 Pain Relevance 1.26

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