INT67641

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 90
Total Number 92
Disease Relevance 46.00
Pain Relevance 14.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
monocytes 20
macrophages 16
neutrophils 6
liver 4
peritoneal macrophages 4
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1100 100.00 Very High Very High Very High
tolerance 67 100.00 Very High Very High Very High
Hyperalgesia 6 100.00 Very High Very High Very High
Nicotine 37 99.78 Very High Very High Very High
agonist 302 99.62 Very High Very High Very High
Central nervous system 108 99.60 Very High Very High Very High
Inflammation 1746 99.54 Very High Very High Very High
midbrain 12 99.22 Very High Very High Very High
Angina 95 99.04 Very High Very High Very High
cINOD 55 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 278 100.00 Very High Very High Very High
Fever 41 100.00 Very High Very High Very High
Hyperalgesia 6 100.00 Very High Very High Very High
Death 235 99.98 Very High Very High Very High
Acute Renal Failure 45 99.88 Very High Very High Very High
Burns 222 99.70 Very High Very High Very High
Cv General 2 Under Development 39 99.60 Very High Very High Very High
INFLAMMATION 1884 99.54 Very High Very High Very High
Infection 379 99.52 Very High Very High Very High
Hemolytic Uremic Syndrome 369 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oral antibiotics feeding after burn significantly decreased TLR4 mRNA expression of intestinal mucosa compared with that of burn group (Figure 5C).
Negative_regulation (decreased) of Gene_expression (expression) of TLR4 mRNA associated with burns
1) Confidence 0.58 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.24 Pain Relevance 0
Diminished TLR-4 expression has also been reported in isolated cells exposed directly to endotoxin [24]; however, the reason for this down-regulation response during infection is not known.
Negative_regulation (Diminished) of Gene_expression (expression) of TLR-4 associated with infection
2) Confidence 0.56 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.64 Pain Relevance 0.17
Using murine macrophage ANA-1 cells, the authors further demonstrated with chloroquine a decreased expression of TLR4 and 9 mRNA expressions as well as a blockade of NF?
Negative_regulation (decreased) of Gene_expression (expressions) of TLR4 in macrophage
3) Confidence 0.51 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.80 Pain Relevance 0.17
mg/d resulted in a 36.2% reduction in TLR4 expression on CD14+ monocytes.
Negative_regulation (reduction) of Gene_expression (expression) of TLR4 in monocytes
4) Confidence 0.51 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.32 Pain Relevance 0.28
Administration of LPS 1 h after indomethacin aggravated the damage, whereas LPS pretreatment inhibited it with reduction of expression of TLR4 and cytokines.
Negative_regulation (reduction) of Gene_expression (expression) of TLR4
5) Confidence 0.50 Published 2008 Journal Gut Section Body Doc Link 17639086 Disease Relevance 0 Pain Relevance 0
Commensal depletion decreased TLR4 expression as well as NF-?
Negative_regulation (decreased) of Gene_expression (expression) of TLR4
6) Confidence 0.43 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2901327 Disease Relevance 1.15 Pain Relevance 0.03
We previously demonstrated that an AD mouse model (Mo/Hu APPswe PS1dE9 mice) homozygous for a destructive mutation of TLR4 (TlrLps-d/TlrLps-d) had increases in diffuse and fibrillar A?
Negative_regulation (destructive) of Gene_expression (mutation) of TLR4 associated with disease
7) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 0.51 Pain Relevance 0.47
Benazepril can inhibit over-expression of TLR4 and reduce serum levels of TNF-?
Negative_regulation (inhibit) of Gene_expression (expression) of TLR4
8) Confidence 0.42 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Abstract Doc Link PMC2956475 Disease Relevance 0.48 Pain Relevance 0.17
Benazepril can inhibit over-expression of TLR4 and reduce serum levels of TNF-?
Negative_regulation (inhibit) of Gene_expression (expression) of TLR4
9) Confidence 0.42 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.56 Pain Relevance 0.18
Benazepril can inhibit over-expression of TLR4 and reduce serum levels of TNF-?
Negative_regulation (inhibit) of Gene_expression (-) of TLR4
10) Confidence 0.42 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.56 Pain Relevance 0.18
Benazepril can inhibit over-expression of TLR4 and reduce serum levels of TNF-?
Negative_regulation (inhibit) of Gene_expression (over) of TLR4
11) Confidence 0.42 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.56 Pain Relevance 0.18
Benazepril can inhibit over-expression of TLR4 and reduce serum levels of TNF-?
Negative_regulation (inhibit) of Gene_expression (-) of TLR4
12) Confidence 0.42 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Abstract Doc Link PMC2956475 Disease Relevance 0.48 Pain Relevance 0.17
Benazepril can inhibit over-expression of TLR4 and reduce serum levels of TNF-?
Negative_regulation (inhibit) of Gene_expression (over) of TLR4
13) Confidence 0.42 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Abstract Doc Link PMC2956475 Disease Relevance 0.48 Pain Relevance 0.17
As shown in Table 2, expressions of TLR4 and levels of TNF-?
Negative_regulation (shown) of Gene_expression (expressions) of TLR4
14) Confidence 0.41 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 1.14 Pain Relevance 0.18
It is estimated that ACEI can stabilize vulnerable plaques of atherosclerosis and reduce the number of acute cardiovascular events by inhibiting the over-expression of TLR4 and reduce serum levels of TNF-?
Negative_regulation (inhibiting) of Gene_expression (over-expression) of TLR4 in plaques associated with increased venous pressure under development
15) Confidence 0.41 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.62 Pain Relevance 0.21
Some reports have demonstrated that expression of TLR4 was mainly localized in infiltrating macrophages in atherosclerotic lesions, suggesting a close link between the progression of coronary atherosclerosis and TLR4 signalling [10,14].
Negative_regulation (localized) of Gene_expression (expression) of TLR4 in macrophages associated with atherosclerosis
16) Confidence 0.41 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 1.01 Pain Relevance 0.04
Glycine inhibits LPS-binding protein (LBP) mRNA expression in the liver mice challenged with LPS, also decreases TLR4 mRNA expression, and decrease activity of NF?
Negative_regulation (decreases) of Gene_expression (expression) of TLR4 mRNA in liver
17) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.36 Pain Relevance 0.30
This further confirms an earlier experiment where nicotine induced a downregulation of TLR4 expression on human monocytes, with or without concomitant LPS stimulation [68].
Negative_regulation (downregulation) of Gene_expression (expression) of TLR4 in monocytes associated with nicotine
18) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.57 Pain Relevance 0.71
They demonstrated a dose dependent decrease of TLR4 mRNA and protein expression in CD14+ human monocytes incubated in vitro with simvastatin or atorvastatin.
Negative_regulation (decrease) of Gene_expression (expression) of TLR4 mRNA in monocytes
19) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.31 Pain Relevance 0.58
Using murine macrophage ANA-1 cells, the authors further demonstrated with chloroquine a decreased expression of TLR4 and 9 mRNA expressions as well as a blockade of NF?
Negative_regulation (decreased) of Gene_expression (expressions) of TLR4 in macrophage
20) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.80 Pain Relevance 0.17

General Comments

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