INT6765

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Context Info
Confidence 0.81
First Reported 1980
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 49
Total Number 50
Disease Relevance 5.11
Pain Relevance 28.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 3
cerebrospinal fluid 2
nucleus 2
amygdala 2
hippocampus 2
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 85 100.00 Very High Very High Very High
opiate 61 100.00 Very High Very High Very High
orphanin 55 100.00 Very High Very High Very High
opioid receptor 55 100.00 Very High Very High Very High
antagonist 39 100.00 Very High Very High Very High
agonist 34 100.00 Very High Very High Very High
Opioid 33 100.00 Very High Very High Very High
Kappa opioid receptor 23 100.00 Very High Very High Very High
Enkephalin 21 100.00 Very High Very High Very High
Dynorphin 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertrophy 3 100.00 Very High Very High Very High
Convulsion 24 99.80 Very High Very High Very High
Hyperalgesia 3 99.40 Very High Very High Very High
Nociception 3 98.92 Very High Very High Very High
Cv General 4 Under Development 2 98.00 Very High Very High Very High
Hypotension 9 97.70 Very High Very High Very High
Hypertension 2 97.40 Very High Very High Very High
Hypoxia 9 96.60 Very High Very High Very High
Cv Unclassified Under Development 6 96.28 Very High Very High Very High
Urological Neuroanatomy 5 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical localization of ORL-1 in the central nervous system of the rat.
Localization (localization) of ORL-1 in central nervous system associated with central nervous system
1) Confidence 0.81 Published 1996 Journal J. Comp. Neurol. Section Title Doc Link 8725304 Disease Relevance 0 Pain Relevance 0.54
Autoradiographic silver grains in emulsion-coated, Nissl-stained sections were preferentially located between cells, suggesting kappa receptor localization on nerve terminals and/or processes of pituicytes.
Localization (localization) of suggesting kappa receptor in nerve
2) Confidence 0.80 Published 1986 Journal Brain Res. Section Abstract Doc Link 3019482 Disease Relevance 0 Pain Relevance 0.24
Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study.
Localization (release) of nociceptin/orphanin FQ in hippocampus associated with convulsion, orphanin, thalamus and hippocampus
3) Confidence 0.80 Published 2004 Journal J. Neurochem. Section Title Doc Link 15379884 Disease Relevance 0.40 Pain Relevance 0.56
Identification of these distributions adds substantially to data identifying the cellular localization of the principal opiate receptor involved in both analgesic and addictive processes.
Localization (localization) of opiate receptor associated with analgesic and opiate
4) Confidence 0.80 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947922 Disease Relevance 0 Pain Relevance 0.89
The localization of opioid receptor-like (ORL-1) orphan receptor in the ventromedial nucleus of the hypothalamus (VMH) suggested a role for this opioid system in the regulation of lordosis behavior.
Localization (localization) of opioid receptor-like in nucleus associated with opioid receptor, lordosis and opioid
5) Confidence 0.78 Published 1997 Journal Neuroreport Section Abstract Doc Link 9462455 Disease Relevance 0.24 Pain Relevance 0.31
In general co-localization of MOR and ORL-1 receptor immunoreactivity was not observed in either perikarya or neuropil in the dorsal root ganglia, nor in the Lissauer's tract and superficial laminae of the spinal cord.
Localization (localization) of ORL-1 receptor in dorsal root ganglia associated with mu opioid receptor and spinal cord
6) Confidence 0.76 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9733084 Disease Relevance 0.33 Pain Relevance 1.36
Opiate receptor localization in rat cerebral cortex.
Localization (localization) of Opiate receptor in cerebral cortex associated with opiate and cerebral cortex
7) Confidence 0.76 Published 1983 Journal J. Comp. Neurol. Section Title Doc Link 6306069 Disease Relevance 0 Pain Relevance 0.71
Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study.
Localization (release) of nociceptin/orphanin FQ in hippocampus associated with convulsion, orphanin, thalamus and hippocampus
8) Confidence 0.75 Published 2004 Journal J. Neurochem. Section Title Doc Link 15379884 Disease Relevance 0.40 Pain Relevance 0.56
The localization of opioid receptor-like (ORL-1) orphan receptor in the ventromedial nucleus of the hypothalamus (VMH) suggested a role for this opioid system in the regulation of lordosis behavior.
Localization (localization) of ORL-1 in nucleus associated with opioid receptor, lordosis and opioid
9) Confidence 0.71 Published 1997 Journal Neuroreport Section Abstract Doc Link 9462455 Disease Relevance 0.24 Pain Relevance 0.31
In neonatal rats intratesticular administration of opiate receptor antagonists (naloxone, nalmefene) stimulates Sertoli cell proliferation and secretion.
Localization (secretion) of opiate receptor in Sertoli cell associated with antagonist, narcan and opiate
10) Confidence 0.71 Published 1991 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 1668613 Disease Relevance 0 Pain Relevance 0.73
The effect of simultaneous intratesticular injection of the opiate receptor antagonist naloxone and the neurotoxic drug 6-hydroxydopamine (6-OHDA) on testicular growth, compensatory testicular hypertrophy, serum testosterone level and basal testosterone secretion in vitro was studied in neonatal rats.
Localization (secretion) of opiate receptor associated with hypertrophy, antagonist, narcan and opiate
11) Confidence 0.71 Published 1989 Journal Andrologia Section Abstract Doc Link 2510556 Disease Relevance 0.22 Pain Relevance 0.38
In conclusion, nociceptin injected into the CNS stimulated gastric acid secretion in rats via the ORL1 receptors and through mechanisms involving the vagus nerve.
Localization (secretion) of ORL1 in vagus nerve associated with orphanin, central nervous system and vagus nerve
12) Confidence 0.68 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12007927 Disease Relevance 0 Pain Relevance 0.73
Gastric acid secretion by central injection of dynorphin A-(1-17), an endogenous ligand of kappa-opioid receptor, in urethane-anesthetized rats.
Localization (secretion) of kappa-opioid receptor associated with anesthesia, dynorphin and kappa opioid receptor
13) Confidence 0.68 Published 2001 Journal Jpn. J. Pharmacol. Section Title Doc Link 11676193 Disease Relevance 0 Pain Relevance 0.92
The LV injection of naloxone benzoylhydrazone (a kappa3-opioid receptor agonist, 100 microg) also stimulated the secretion in norbinaltorphimine-sensitive manner.
Localization (secretion) of kappa3-opioid associated with agonist, narcan and opioid receptor
14) Confidence 0.68 Published 2001 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11676193 Disease Relevance 0 Pain Relevance 1.10
The specific preoptic region involved in opiate regulation of maternal behavior may be illustrated by the zone of opiate receptor alteration observed herein.
Localization (alteration) of opiate receptor in preoptic region associated with opiate
15) Confidence 0.66 Published 1987 Journal Brain Res. Section Abstract Doc Link 2823974 Disease Relevance 0 Pain Relevance 1.01
CONCLUSIONS: Taken together, our results suggests that mu-opioid receptors in both shell and core portions of the nucleus accumbens, and possibly kappa-opioid in the core, participate in the modulation of rapid tolerance to ethanol.


Localization (portions) of kappa-opioid in nucleus accumbens
16) Confidence 0.65 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 19506836 Disease Relevance 0 Pain Relevance 0
The present study examines the localization of the kappa 1 receptor, a region of the receptor that has little homology with mu and delta receptors.
Spec (examines) Localization (localization) of kappa 1 receptor
17) Confidence 0.65 Published 1996 Journal Neuroscience Section Abstract Doc Link 8867040 Disease Relevance 0 Pain Relevance 0.23
Immunohistochemical localization of the cloned kappa 1 receptor in the rat CNS and pituitary.
Localization (localization) of kappa 1 receptor in pituitary
18) Confidence 0.65 Published 1996 Journal Neuroscience Section Title Doc Link 8867040 Disease Relevance 0 Pain Relevance 0.28
Presence of morphine in rat amygdala: evidence for the mu3 opiate receptor subtype via nitric oxide release in limbic structures.
Localization (release) of opiate receptor in amygdala associated with opiate, amygdala and morphine
19) Confidence 0.64 Published 2004 Journal Med. Sci. Monit. Section Title Doc Link 15567973 Disease Relevance 0 Pain Relevance 0.62
Furthermore, depletion of PKC by 12-O-tetradecanoylphorbol-13-acetate exposure (48 h, 1 microM) also prevented OFQ/N-mediated mu and ORL1 desensitization.
Localization (desensitization) of ORL1
20) Confidence 0.62 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130708 Disease Relevance 0 Pain Relevance 0.66

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