INT67653

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 15.28
Pain Relevance 13.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryos 1
spinal cord 1
internal 1
thoracic 1
oocytes 1
Om (Mus musculus)
Om - S196A (2) Om - Y745H (2)
Pain Link Frequency Relevance Heat
aspirin 14 100.00 Very High Very High Very High
sodium channel 8 99.96 Very High Very High Very High
narcan 85 99.92 Very High Very High Very High
opioid receptor 38 99.86 Very High Very High Very High
Hippocampus 99 99.68 Very High Very High Very High
Pain 70 99.56 Very High Very High Very High
potassium channel 16 99.34 Very High Very High Very High
agonist 37 99.32 Very High Very High Very High
qutenza 103 99.28 Very High Very High Very High
cerebral cortex 7 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 438 99.88 Very High Very High Very High
Disease 319 99.66 Very High Very High Very High
Pain 102 99.56 Very High Very High Very High
Apoptosis 246 98.80 Very High Very High Very High
Drug Dependence 16 98.68 Very High Very High Very High
Infection 65 98.32 Very High Very High Very High
Motor Neuron Diseases 202 98.28 Very High Very High Very High
Neuropathic Pain 64 97.72 Very High Very High Very High
Bordatella Infection 1 97.60 Very High Very High Very High
Depression 447 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whole-cell voltage-clamp experiments were performed on HEK 293 cells expressing R1448H mutant sodium channels.
Gene_expression (expressing) of R1448H mutant (R1448H) associated with sodium channel
1) Confidence 0.36 Published 2001 Journal Muscle Nerve Section Abstract Doc Link 11360256 Disease Relevance 0.33 Pain Relevance 0.29
Direct injection of double-stranded adeno-associated virus type 2 (dsAAV2) with a mu-opioid receptor (MOR) mutant [S4.45(196)A], and a reporter protein (enhanced green fluorescent protein) into the spinal cord (S2/S3) dorsal horn region of ICR mice resulted in antinociceptive responses to systemic injection of opioid antagonist naloxone without altering the acute agonist morphine responses and no measurable tolerance or dependence development during subchronic naloxone treatment.
Gene_expression ([S4.45) of mutant in spinal cord associated with narcan, dorsal horn, opioid receptor, antinociceptive, morphine, spinal cord, addiction, antagonist, tolerance, agonist and opioid
2) Confidence 0.17 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20554907 Disease Relevance 0.07 Pain Relevance 0.91
Buprenorphine did not affect cAMP accumulation in HEK 293 cells expressing the D95N mutant, and it blocked the ability of DSLET and bremazocine to inhibit cAMP accumulation via the D95N mutant, which indicated that buprenorphine acts as an antagonist at the D95N mutant.
Gene_expression (expressing) of D95N mutant (D95N) associated with antagonist and buprenorphine
3) Confidence 0.12 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9435189 Disease Relevance 0 Pain Relevance 1.15
Overexpression of a dominant negative CREB mutant blocked the increase in LC excitability induced by morphine- or cAMP-pathway activation.
Gene_expression (Overexpression) of mutant associated with locus ceruleus and morphine
4) Confidence 0.06 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.08 Pain Relevance 1.20
Differential analysis of P0 WT versus P0 TrkA mutant mice libraries
Gene_expression (libraries) of mutant
5) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0
Differential analysis of P0 WT versus P0 TrkA mutant mice libraries
Gene_expression (versus) of mutant
6) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0
The predicted product of the mutant ?
Gene_expression (product) of mutant
7) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100059 Disease Relevance 0.39 Pain Relevance 0
In the thin rod test, the retention times on a thin stationary plexiglass rod for the wild-type and mutant mice were indistinguishable (ANOVA with repeated measures, genotype effect, F(1,29)?
Gene_expression (wild-type) of mutant
8) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.19 Pain Relevance 0.06
There were no significant differences between the wild-type and mutant PCs in basal electrical properties including input resistance, resting potential, AP firing frequency, amplitude, threshold and half-height width (Table 1).
Gene_expression (wild-type) of mutant associated with action potential
9) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.22 Pain Relevance 0.23
No significant difference was detected between the wild-type and mutant mice in terms of the amplitude and time course of the mGluR1-mediated slow synaptic response (Fig. 4A, Table 1).
Gene_expression (wild-type) of mutant
10) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.66 Pain Relevance 0.33
Expression levels in the mutant mice were estimated as percentages of those in the wild-type mice using NSE as an internal standard.


Gene_expression (Expression) of mutant in internal
11) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0 Pain Relevance 0.11
However, in the presence of NGF, a significant reduction of 18,3% (Fig. 6H) was observed in the length of neurites in Necdin mutant explants cultured, compared to the control (Fig. 6), suggesting that Necdin deficiency impairs the neurites extension induced by NGF signalling in DRGs explants.


Gene_expression (explants) of mutant in neurites
12) Confidence 0.03 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.21 Pain Relevance 0
At E11.5 a quantitative analysis of each Trk-expressing cell subpopulation in lumbar DRGs (L1 to L5), revealed no difference between wild type and mutant embryos (data not shown).
Gene_expression (embryos) of mutant in embryos
13) Confidence 0.03 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.06 Pain Relevance 0
At E11.5, in Necdin mutant embryos, the brachial plexus, formed by the last three cervical and first two thoracic nerves, in the forelimb was appropriately patterned and all nerves emanating from it appear normal compared to wild type (data not shown).
Gene_expression (embryos) of mutant in thoracic
14) Confidence 0.03 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.07 Pain Relevance 0
We then compared the number of cells expressing p75NTR in the lumbar DRGs of wild type and Necdin mutant.
Gene_expression (expressing) of mutant
15) Confidence 0.03 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.12 Pain Relevance 0
APPPS1 mouse model expresses ‘Swedish’ mutant APP and M146L mutant presenilin [28] whereas R1.40 mice express only ‘Swedish’ mutant APP [29].
Gene_expression (del expre) of M146L mutant (M146L)
16) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912762 Disease Relevance 0.54 Pain Relevance 0
L25NMe was chemically synthesized, and the wild type (WT), trapped dimer R26C, and the inactive R6K mutant were recombinantly expressed.


Gene_expression (expressed) of R6K mutant
17) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.30 Pain Relevance 0.13
Although the elevated basal DA tone is due to reduced DAT activity in all mouse lines, the causes of the reduction are different; reduced expression of wild type DAT, in heterozygous DAT-KO and DAT-KD mice, versus normal expression of a mutant DAT with lower uptake activity in DAT-CI mice.
Gene_expression (expression) of mutant associated with dopamine
18) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.48
Generation of point-mutant TRPM8-Y745H
Gene_expression (Generation) of mutant
19) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0.10 Pain Relevance 0.25
Expression and functional phenotype of the TRPM8-Y745H mutant
Gene_expression (Expression) of mutant (Y745H)
20) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.15

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