INT67670

Context Info Confidence 0.21 First Reported 1996 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.60 Pain Relevance 0.59

Anatomy Link Frequency lung 1 SCLC1 (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 2 100.00 cytokine 12 88.00 agonist 3 80.96 Sumatriptan 3 76.16 antagonist 4 68.24 Potency 1 65.12 Opioid 1 50.24 Central nervous system 1 5.00 anesthesia 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Small Cell Lung Cancer 22 100.00 Lung Cancer 2 100.00 Syndrome 34 99.78 Death 1 89.72 Apoptosis 3 86.12 Cytomegalovirus Infection 20 76.40 Cancer 15 36.04 Necrosis 2 27.76 Skin Cancer 2 5.00 Neurological Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

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Anatomy

Negation

Speculation

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Disease term

We previously reported a significant mitogenic effect of serotonin (5-hydroxytryptamine, 5-HT) on human small-cell lung carcinoma cells (SCLC, GLC-8), mediated by both 5-HT1D and 5-HT1A receptors.

Regulation (effect) of SCLC in lung associated with lung cancer, small cell lung cancer and serotonin

1) Confidence 0.21 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016944 Disease Relevance 0.28 Pain Relevance 0.39

after stimulation with HuDmix in Hu-PNS patients, SCLC and healthy controls.

Regulation (controls) of SCLC associated with syndrome and small cell lung cancer

2) Confidence 0.14 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.70 Pain Relevance 0.12

Together, these results show that naltrindole is a new inhibitor of the Akt/PKB signaling pathway, suggesting that naltrindole could be a potential lead for the development of a new type of inhibitors that target the constitutively active Akt/PKB signaling-dependent SCLC cells.

Regulation (target) of SCLC associated with small cell lung cancer

3) Confidence 0.07 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15574783 Disease Relevance 0.62 Pain Relevance 0.08

General Comments

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