INT67681

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.37
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
microglia 8
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 4 99.96 Very High Very High Very High
antagonist 12 99.84 Very High Very High Very High
Dopamine 3 99.84 Very High Very High Very High
Glutamate 3 98.84 Very High Very High Very High
substance P 4 98.28 Very High Very High Very High
long-term potentiation 40 96.96 Very High Very High Very High
tetrodotoxin 4 96.24 Very High Very High Very High
intrathecal 10 95.92 Very High Very High Very High
withdrawal 2 94.00 High High
allodynia 20 93.52 High High
Disease Link Frequency Relevance Heat
Hypoxia 5 99.82 Very High Very High Very High
Nervous System Injury 56 95.68 Very High Very High Very High
Neuropathic Pain 129 93.52 High High
Stress 9 92.12 High High
Anaerobic Bacterial Infections 2 88.56 High High
Shock 3 78.40 Quite High
Hypersensitivity 19 78.04 Quite High
Pain 60 77.36 Quite High
Injury 14 69.92 Quite High
Urological Neuroanatomy 3 57.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preventing BDNF release from microglia by pretreating them with interfering RNA directed against BDNF before ATP stimulation also inhibits the effects of these cells on the withdrawal threshold and E(anion).
Negative_regulation (Preventing) of Localization (release) of BDNF in microglia associated with withdrawal
1) Confidence 0.50 Published 2005 Journal Nature Section Abstract Doc Link 16355225 Disease Relevance 0.83 Pain Relevance 0.75
The release of BDNF is abolished by inhibiting SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor)-mediated exocytosis.
Negative_regulation (abolished) of Localization (release) of BDNF
2) Confidence 0.45 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.45 Pain Relevance 0.29
The NMDA antagonist d-AP-5 inhibited electrically evoked BDNF release.
Negative_regulation (inhibited) of Localization (release) of BDNF associated with antagonist
3) Confidence 0.43 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.94
For all stimulation protocols tested, removal of extracellular calcium, or blockade of N-type calcium channels, prevented BDNF release.
Negative_regulation (prevented) of Localization (release) of BDNF associated with calcium channel
4) Confidence 0.43 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451139 Disease Relevance 0.09 Pain Relevance 0.32
Surprisingly, we also found that IH-induced secretion of BDNF was blocked by dopamine D2 receptor antagonists or by inhibition of dopamine synthesis with alpha-methyl-p-tyrosine.
Negative_regulation (blocked) of Localization (secretion) of BDNF associated with dopamine, hypoxia and antagonist
5) Confidence 0.41 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.70 Pain Relevance 0.31
The results suggested that the evoked release was independent of the presence of extracellular calcium ions, but dependent on intracellular calcium ion stores, since the intracellular calcium ion chelator BAPTA-AM, but not the extracellular chelator EGTA abolished the high-potassium-induced [125I]BDNF release from synaptosomes.
Negative_regulation (abolished) of Localization (release) of BDNF
6) Confidence 0.38 Published 1996 Journal Brain Res. Section Abstract Doc Link 9017228 Disease Relevance 0 Pain Relevance 0.21
Similarly, depletion of intracellular calcium stores with thapsigargin and treatment with dantrolene, an inhibitor of calcium release from caffeine-ryanodine-sensitive stores, markedly inhibited activity-dependent BDNF release.
Negative_regulation (inhibited) of Localization (release) of BDNF
7) Confidence 0.38 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451139 Disease Relevance 0.08 Pain Relevance 0.25
The late phase of BDNF release and accumulation, but not the early phase of release, are suppressed by inhibiting transcription and translation, indicating that activation of P2X4R causes an initial release of a pre-existing pool of BDNF followed by an increase in de novo synthesis of BDNF.
Negative_regulation (suppressed) of Localization (release) of BDNF
8) Confidence 0.33 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.50 Pain Relevance 0.30
In addition, pretreatment of the microglia with BDNF siRNA prevented release of BDNF by ATP stimulation.
Negative_regulation (prevented) of Localization (release) of BDNF in microglia
9) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.59 Pain Relevance 0.46
Is it required for synaptic plasticity or does it reflect a delayed, compensatory resynthesis following BDNF release?
Negative_regulation (resynthesis) of Localization (release) of BDNF
10) Confidence 0.29 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.06 Pain Relevance 0.51
In addition, pretreatment of the microglia with BDNF siRNA prevented release of BDNF by ATP stimulation.
Negative_regulation (prevented) of Localization (release) of BDNF in microglia
11) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.66 Pain Relevance 0.48
Pretreatment with antibodies against tryptase or PAR2, or using tryptase-deficient HMC-1 cells or PAR2-deficient microglial cells abolished the increase in P2X4R expression and BDNF release.
Negative_regulation (abolished) of Localization (release) of BDNF in microglial cells
12) Confidence 0.06 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.41 Pain Relevance 0.25

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