INT67682

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Context Info
Confidence 0.81
First Reported 1996
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 204
Total Number 207
Disease Relevance 72.36
Pain Relevance 88.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
neurons 23
brain 22
microglia 18
spinal cord 9
dorsal horn 6
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 2195 100.00 Very High Very High Very High
Nerve growth factor 544 100.00 Very High Very High Very High
substance P 294 100.00 Very High Very High Very High
qutenza 255 100.00 Very High Very High Very High
Neuropeptide 115 100.00 Very High Very High Very High
antidepressant 98 100.00 Very High Very High Very High
Serotonin 40 100.00 Very High Very High Very High
neurotrophin 3 8 100.00 Very High Very High Very High
Somatostatin 8 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 404 100.00 Very High Very High Very High
Adhesions 9 100.00 Very High Very High Very High
Headache 27 99.92 Very High Very High Very High
Injury 698 99.90 Very High Very High Very High
Hypoxia 50 99.82 Very High Very High Very High
Stress 189 99.70 Very High Very High Very High
INFLAMMATION 290 99.62 Very High Very High Very High
Urological Neuroanatomy 47 99.56 Very High Very High Very High
Neuropathic Pain 996 99.52 Very High Very High Very High
Nociception 220 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following sciatic nerve transection (performed 14 days previously), release of BDNF was found throughout the whole of the dorsal horn, extending into deeper laminae.
Localization (release) of BDNF in sciatic nerve associated with dorsal horn and sciatic nerve
1) Confidence 0.81 Published 2001 Journal Brain Res. Section Abstract Doc Link 11311885 Disease Relevance 0 Pain Relevance 0.46
These data demonstrate that BDNF is released in association with an endogenous rhythmic activity generated by the developing CNS.
Localization (released) of BDNF
2) Confidence 0.81 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671864 Disease Relevance 0 Pain Relevance 0.30
Similarly, the amount of BDNF released by burst stimulation was increased after NGF treatment.
Localization (released) of BDNF
3) Confidence 0.80 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.88
These experiments demonstrate that BDNF release in the dorsal horn is encoded by specific patterns of afferent fiber stimulation and is mediated by NMDA receptor activation.
Localization (release) of BDNF in dorsal horn associated with nmda receptor and dorsal horn
4) Confidence 0.80 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.72
Here we show that BDNF is released in the rat isolated dorsal horn after chemical stimulation by capsaicin or electrical stimulation of dorsal roots.
Localization (released) of BDNF in dorsal horn associated with qutenza and dorsal horn
5) Confidence 0.80 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.61
BDNF release was also seen after electrical stimulation of the dorsal roots at C-fiber strength.
Localization (release) of BDNF in dorsal roots associated with c fibre
6) Confidence 0.80 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.80
BDNF release was also measured after systemic or intrathecal NGF treatment.
Localization (release) of BDNF associated with intrathecal
7) Confidence 0.80 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.92
In the present study, we evaluated the change of BDNF mRNA in the DRG following peripheral inflammation and also observed colocalization of BDNF and trkA mRNAs by means of in situ hybridization histochemistry in rats.
Localization (colocalization) of BDNF in DRG associated with dorsal root ganglion and inflammation
8) Confidence 0.80 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.89 Pain Relevance 0.74
The bio-active BDNF protein was also secreted by the cells during both growth conditions, as measured by ELISA analysis of BDNF content and secretion.
Localization (secreted) of BDNF
9) Confidence 0.80 Published 2000 Journal Pain Section Abstract Doc Link 10779676 Disease Relevance 0.80 Pain Relevance 0.77
Our results indicate that BDNF release can encode temporal features of hippocampal neuronal activity.
Localization (release) of BDNF in neuronal
10) Confidence 0.80 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451139 Disease Relevance 0.08 Pain Relevance 0.24
Localization of BDNF in the spinal cord following surgical incision
Localization (Localization) of BDNF in spinal cord associated with bdmf and spinal cord
11) Confidence 0.80 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0 Pain Relevance 0.82
However, it is unknown whether or not oxidative stress actually increases availability of BDNF by stimulating BDNF secretion.
Localization (secretion) of BDNF associated with stress
12) Confidence 0.77 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.64 Pain Relevance 0.10
Surprisingly, we also found that IH-induced secretion of BDNF was blocked by dopamine D2 receptor antagonists or by inhibition of dopamine synthesis with alpha-methyl-p-tyrosine.
Localization (secretion) of BDNF associated with dopamine, hypoxia and antagonist
13) Confidence 0.77 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16390493 Disease Relevance 0.70 Pain Relevance 0.31
To localize Htt and BDNF mRNA, rat cortical neurons (DIV 8) were stained for endogenous Htt with an antibody to Htt (MAB2166, Millipore).
Localization (localize) of BDNF in neurons
14) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.19 Pain Relevance 0
This is a number-based analysis; i.e., we analyze co-localization of BDNF mRNA granules and puncta staining of proteins.
Spec (analyze) Localization (localization) of BDNF
15) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
A previous study reported differential localization of the two BDNF mRNA populations in neurons; however, the basis for this phenomenon remains unclear [18].
Localization (localization) of BDNF in neurons
16) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
Upon tissue injury or noxious stimulation, SP and BDNF are released into laminae I and II of the spinal cord dorsal horn, where through activation of their respective postsynaptic receptors, neurokinin-1 (NK-1) and tyrosine kinase B (trkB), contribute to development of hyperalgesia and central sensitization associated with chronic pain [15-18].
Localization (released) of BDNF in spinal cord dorsal horn associated with hyperalgesia, central sensitization, lasting pain, injury, dorsal horn, spinal cord and substance p
17) Confidence 0.76 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 1.01 Pain Relevance 1.24
Furthermore, the finding that SIS significantly decreased acetylated H3 at the promoters of exon I and IV of the BDNF gene indicates that epigenetic mechanisms play a role in the stress-induced changes in distinct BDNF transcripts in the hippocampus.
Localization (decreased) of BDNF in hippocampus associated with stress and hippocampus
18) Confidence 0.75 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.93 Pain Relevance 0.23
A recent in vitro study (20) provided very intriguing evidence for neuroprotection by endothelium-derived BDNF secretion mediated by integrin signaling.
Localization (secretion) of BDNF in endothelium
19) Confidence 0.72 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 1.55 Pain Relevance 0.07
A recent study (20) provided evidence that BDNF released from endothelial cells protects the neurons from a wide array of insults.
Localization (released) of BDNF in neurons
20) Confidence 0.72 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.97 Pain Relevance 0.52

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