INT67693

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Context Info
Confidence 0.38
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 1.74
Pain Relevance 5.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
neurons 4
spines 2
adult brain 1
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 62 100.00 Very High Very High Very High
agonist 25 100.00 Very High Very High Very High
Glutamate 78 99.90 Very High Very High Very High
Morphine 14 99.22 Very High Very High Very High
anesthesia 4 98.88 Very High Very High Very High
tolerance 41 98.04 Very High Very High Very High
withdrawal 38 97.36 Very High Very High Very High
antagonist 42 97.28 Very High Very High Very High
butorphanol 9 96.72 Very High Very High Very High
depression 91 94.88 High High
Disease Link Frequency Relevance Heat
Disease 162 95.20 Very High Very High Very High
Depression 91 94.88 High High
Cognitive Disorder 54 91.80 High High
Pain 1 83.00 Quite High
Death 21 78.28 Quite High
Injury 3 77.92 Quite High
Li-fraumeni Syndrome 16 72.40 Quite High
Glaucoma 56 66.68 Quite High
Drug Dependence 26 50.00 Quite Low
Apoptosis 49 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using immunohistochemical double-labeling with a specific antibody recognizing both NR2A and NR2B subunits, we studied the cellular distribution of the NMDA receptor subunit NR2A/2B on all major known striatal neuron types.
NR2A Binding (recognizing) of in neuron associated with nmda receptor
1) Confidence 0.38 Published 1996 Journal Brain Res. Section Abstract Doc Link 9017267 Disease Relevance 0 Pain Relevance 0.19
Using an electron microscope, approximately 5600 cortical spines originating from the two hemispheres of the seven adult animals were analyzed for the location of NR2A subunits.
NR2A Spec (analyzed) Binding (location) of in spines
2) Confidence 0.35 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560119 Disease Relevance 0 Pain Relevance 0.11
NMDARs in adult brain are heteromeric complexes of NR1 and NR2A or NR2B subunit.
NR2A Binding (complexes) of in adult brain
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.92 Pain Relevance 1.01
These results suggest that region-specific changes of NMDA receptor subunit mRNA (NR1 and NR2) as well as NMDA receptor binding ([3H]MK-801) are involved in the development of tolerance to and withdrawal from butorphanol.
NR2 Binding (binding) of associated with nmda receptor, butorphanol, tolerance and withdrawal
4) Confidence 0.34 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.50
NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities, and axon terminals.
NR2A Binding (trafficking) of in spines associated with nmda receptor
5) Confidence 0.31 Published 2003 Journal Brain Res. Section Title Doc Link 12560119 Disease Relevance 0 Pain Relevance 0.23
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
NR2A Spec (whether) Binding (association) of associated with cognitive disorder and morphine
6) Confidence 0.30 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.52
Immunofluorescence with an antibody that recognized NR1 and another that recognized NR2A and NR2B showed that NR1 and NR2B colocalized in 90% of DRG neurons, including most A-fibers (identified by the presence of neurofilament 200 kDa).
NR2A Binding (recognized) of in neurons
7) Confidence 0.29 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.08 Pain Relevance 0.24
Glutamate can bind as an agonist to the NR2 subunits.
NR2 Binding (bind) of associated with glutamate and agonist
8) Confidence 0.27 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695219 Disease Relevance 0.16 Pain Relevance 0.55
Thus, both depolarization of the postsynaptic neuron and binding of agonists at NR1 and NR2 is required for flow of Ca2+ through the NMDAR channel.
NR2 Binding (binding) of in neuron associated with agonist
9) Confidence 0.24 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695219 Disease Relevance 0.18 Pain Relevance 0.37
NMDA antagonists are structurally diverse, and act on these multiple, allosterically coupled recognition sites.12 NMDA receptors with different NR1 and NR2 subunit combinations have different electrophysiological and pharmacological properties.10 Moreover, the NR1 subunits are formed from a single gene product with eight splice variants, whereas NR2 subunits form four different gene products (NR2A, NR2B, NR2C, and NR2D).13 NMDA receptors show distinct distribution patterns in the adult rat brain compared with the developing brain, suggesting that there might be different populations of neurons with unique NMDA receptor subunit compositions and distinct pharmacological properties.14,15
NR2 Binding (combinations) of in neurons associated with nmda receptor and antagonist
10) Confidence 0.17 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615322 Disease Relevance 0 Pain Relevance 0.51
The NR1 contains a specific glutamate-binding site, whereas the NR2 binds to glycine, which acts as a co-agonist for receptor activation.
NR2 Binding (binds) of associated with glutamate and agonist
11) Confidence 0.00 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 0.23 Pain Relevance 0.45

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