INT677

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Context Info
Confidence 0.67
First Reported 1978
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 17.47
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CST3) extracellular region (CST3) endoplasmic reticulum (CST3)
lysosome (CST3) cytoplasm (CST3)
Anatomy Link Frequency
CSF 3
joint 1
plasma 1
liver 1
temporomandibular joint 1
CST3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 19 100.00 Very High Very High Very High
cva 4 99.80 Very High Very High Very High
pain labor 2 99.74 Very High Very High Very High
rheumatoid arthritis 14 99.60 Very High Very High Very High
Dorsal horn 2 99.44 Very High Very High Very High
Dysuria 1 98.70 Very High Very High Very High
Pain 45 98.52 Very High Very High Very High
Snapping jaw 1 98.42 Very High Very High Very High
headache 2 97.24 Very High Very High Very High
cINOD 8 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 22 100.00 Very High Very High Very High
Anaemia 2 99.82 Very High Very High Very High
Cv General 3 Under Development 10 99.80 Very High Very High Very High
Labor Pain 2 99.74 Very High Very High Very High
Iritis 1 99.66 Very High Very High Very High
Rheumatoid Arthritis 15 99.60 Very High Very High Very High
Urinary Tract Infection 1 99.52 Very High Very High Very High
Diabetes Mellitus 39 99.44 Very High Very High Very High
Injury 14 99.24 Very High Very High Very High
Malignant Neoplastic Disease 3 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A subsequent study of 10 women suggested that prolonged labor pain resulted in increased cystatin C concentrations in cerebrospinal fluid, and that this could be used as a biomarker for pain.
Positive_regulation (increased) of cystatin C in cerebrospinal fluid associated with pain and pain labor
1) Confidence 0.67 Published 2004 Journal Pain Section Abstract Doc Link 14736582 Disease Relevance 0.83 Pain Relevance 0.83
The median cystatin C concentration in normal volunteers, 2.2 microg/ml, was similar to that previously reported by multiple investigators, and cystatin C concentrations were increased in women in labor (3.9 microg/ml).
Positive_regulation (increased) of cystatin C
2) Confidence 0.67 Published 2004 Journal Pain Section Abstract Doc Link 14736582 Disease Relevance 1.14 Pain Relevance 1.22
We hypothesized that, concurrent with increased expression in dorsal horn, increased secretion would elevate the cystatin C content in cerebrospinal fluid (CSF) during active pain states.
Positive_regulation (elevate) of cystatin C in CSF associated with pain and dorsal horn
3) Confidence 0.67 Published 2003 Journal Pain Section Abstract Doc Link 12670666 Disease Relevance 0.39 Pain Relevance 0.40
The cystatin C increase also was detectable by SELDI with either raw CSF or after antibody capture.
Positive_regulation (increase) of cystatin C in CSF
4) Confidence 0.67 Published 2003 Journal Pain Section Abstract Doc Link 12670666 Disease Relevance 0.65 Pain Relevance 0.69
The denaturation of human gamma globulin was induced by Cu++ at 10 micrometer ("Cu++ induced denaturation") and was further increased by heating at 63 degrees C for 3 hr in the presence of Cu++ ("total denaturation").
Positive_regulation (induced) of gamma globulin
5) Confidence 0.60 Published 1978 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 77827 Disease Relevance 0.10 Pain Relevance 0.10
Sixty percent of the RA patients exhibited elevated levels of plasma cystatin C, whereas only three out of 56 patients showed an elevated plasma creatinine, even though the creatinine clearance was decreased in 57% of these patients.
Positive_regulation (elevated) of cystatin C in plasma associated with disorders of creatine metabolism and rheumatoid arthritis
6) Confidence 0.49 Published 2000 Journal Clin. Chim. Acta Section Abstract Doc Link 10958875 Disease Relevance 1.19 Pain Relevance 0.44
Elevated cystatin C indicates such incipient renal disease, and is, not least because of a simple, well reproducible technique, more recommendable for screening purposes than tedious clearance determinations.
Positive_regulation (Elevated) of cystatin C associated with renal disease
7) Confidence 0.49 Published 2000 Journal Clin. Chim. Acta Section Abstract Doc Link 10958875 Disease Relevance 1.10 Pain Relevance 0.37
METHODS: Serum, urinary NGAL, cystatin C, urinary kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and liver-type fatty acid binding protein (L-FABP) were evaluated before and 2, 4, 8, 24, and 48 hours after cardiac catheterization using commercially available kits.
Positive_regulation (evaluated) of cystatin C in liver
8) Confidence 0.49 Published 2009 Journal Ren Fail Section Body Doc Link 20030526 Disease Relevance 0.28 Pain Relevance 0
[A case of lobar cerebral hemorrhage with low concentration of CSF cystatin C].
Positive_regulation (concentration) of cystatin C associated with cva
9) Confidence 0.49 Published 1991 Journal Rinsho Shinkeigaku Section Title Doc Link 1914334 Disease Relevance 0.79 Pain Relevance 0.23
Multiple linear regression analysis demonstrated that significantly higher serum levels of cathepsin S in patients with either atherosclerotic stenosis (p<0.04) or diabetes (p=0.0005) persisted after adjustment for cystatin C level, renal function, smoking, and serum glucose levels (p=0.008, p=0.0005).
Positive_regulation (adjustment) of cystatin C associated with nicotine addiction, pathologic constriction, diabetes mellitus and atherosclerosis
10) Confidence 0.49 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16140306 Disease Relevance 1.91 Pain Relevance 0.17
For pragmatic reasons, a combination of cTnI >or=0.1 microg/L, ECG findings and a marker of renal function, preferably cystatin C, appears to be most appropriate for early risk stratification of these patients.


Spec (appears) Positive_regulation (appropriate) of cystatin C
11) Confidence 0.49 Published 2008 Journal Int. J. Cardiol. Section Body Doc Link 17662484 Disease Relevance 0.05 Pain Relevance 0
Despite the above mentioned mechanisms, there is no evidence that elevation of serum cystatin C in actual clinical conditions is associated with cardiovascular disease by inflammation.
Positive_regulation (elevation) of cystatin C associated with inflammation and cardiovascular disease
12) Confidence 0.45 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.01 Pain Relevance 0.20
There is an increase in the levels of lactoferrin, beta(2)-microglobulin, sodium, lysozyme C, and cystatin C, and a decrease in salivary amylase and carbonic anhydrase.
Positive_regulation (se in th) of cystatin C
13) Confidence 0.45 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18362310 Disease Relevance 1.84 Pain Relevance 0.06
Serum cystatin C is elevated earlier than creatinine.
Positive_regulation (elevated) of cystatin C
14) Confidence 0.45 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC2989717 Disease Relevance 1.03 Pain Relevance 0.04
Immunoelectrophoresis revealed an elevated gamma-globulin fraction with IgG lambda monoclonal component, as well as a different lambda light chain.
Positive_regulation (elevated) of gamma-globulin
15) Confidence 0.41 Published 2008 Journal Orv Hetil Section Abstract Doc Link 18547895 Disease Relevance 1.21 Pain Relevance 0.08
Other problems have included temporomandibular joint pain, dysuria without apparent urinary tract infection iritis, anemia, and an elevated gamma globulin fraction.
Neg (without) Positive_regulation (elevated) of gamma globulin in temporomandibular joint associated with pain, snapping jaw, anaemia, dysuria, iritis and urinary tract infection
16) Confidence 0.41 Published 1988 Journal Am. J. Med. Genet. Section Abstract Doc Link 3223492 Disease Relevance 0.98 Pain Relevance 0.55
Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values?
Positive_regulation (neutrophil-gelatinase-associated) of cystatin C in neutrophil associated with angina and renal disease
17) Confidence 0.21 Published 2007 Journal Kidney Blood Press. Res. Section Title Doc Link 17901710 Disease Relevance 0.56 Pain Relevance 0.10
Both patients had elevated polyclonal gamma-globulin levels and rheumatoid factors and, in case 2 an increase of IgG in serum.
Positive_regulation (elevated) of gamma-globulin
18) Confidence 0.17 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2176142 Disease Relevance 1.08 Pain Relevance 0.13
It was less inhibited after both types of injections (Post2), and increased at Post3 again (P<0.05) with no significant difference between the glutamate and isotonic saline sessions.
Positive_regulation (increased) of Post3
19) Confidence 0.01 Published 2007 Journal Clin Neurophysiol Section Body Doc Link 17368095 Disease Relevance 0.08 Pain Relevance 0
We found that (1) dielectric scanning diagrams after joint liquid analyses showed similar negative dielectric parameters in group A (inflammatory), B (degenerative) and C (post-accident) with scanning frequencies of about 10,000,000-3501,300 Hz and similar positive parameters of about 3501,300-1593,700 Hz, but qualitative difference dielectric parameters in group A with a frequency of 1593,700-1225,900 Hz, probably dependent on the inflammatory gamma-globulin concentration; (2) higher dielectric parameters (groups B, C) at a scanning frequency of 94,300-57,600 Hz probably dependent on ion concentration; (3) parametric changes of frequency scanning differentiating the diagrams between groups A and B, C, defining the outline pilot study recommended ranges of frequency and temperature testing for further investigations.
Positive_regulation (dependent) of gamma-globulin in joint associated with inflammation
20) Confidence 0.01 Published 2006 Journal Physiol Meas Section Abstract Doc Link 17135704 Disease Relevance 0.61 Pain Relevance 0.23

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