INT67704

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.69
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
capillary 2
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 8 99.44 Very High Very High Very High
Paracetamol 9 98.96 Very High Very High Very High
antidepressant 1 94.16 High High
antagonist 8 75.04 Quite High
opiate 1 70.56 Quite High
Inflammation 33 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 1 100.00 Very High Very High Very High
Cancer 116 99.96 Very High Very High Very High
Glioma 1 97.92 Very High Very High Very High
Adhesions 1 76.72 Quite High
Prostate Cancer 7 73.44 Quite High
Metastasis 3 67.92 Quite High
Carcinoma 3 54.68 Quite High
Brain Tumor 1 22.32 Low Low
Lung Cancer 1 5.20 Low Low
INFLAMMATION 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, methadone appears to be a mixed-type inhibitor and not a suicide inhibitor of cytochrome P450 3A family.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of P450 associated with suicidal behaviour and methadone
1) Confidence 0.41 Published 1997 Journal Toxicology Section Abstract Doc Link 9020195 Disease Relevance 0.10 Pain Relevance 0.81
Incubation with cycloheximide caused a decrease in fentanyl metabolism secondary to a decrease in P450 levels that was prevented by the coincubation with APAP.
Negative_regulation (prevented) of Negative_regulation (decrease) of P450 associated with paracetamol
2) Confidence 0.13 Published 2002 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 11811955 Disease Relevance 0 Pain Relevance 0.79
In a separate study, two mechanistically different synthetic inhibitors of cytochrome P450, 17-ODYA, and miconazole significantly reduced tumor size and capillary formation in intracranial glial tumors, and prolonged survival of treated rats [124].
Negative_regulation (reduced) of Negative_regulation (inhibitors) of P450 in capillary associated with cancer and glioma
3) Confidence 0.02 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.59 Pain Relevance 0.07

General Comments

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