INT67719

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 8.87
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
molecular_function (Col1a1) cytoplasm (Col1a1)
Anatomy Link Frequency
hearts 2
smooth muscle 1
PSCs 1
basal lamina 1
thickening 1
Col1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 13 99.72 Very High Very High Very High
metalloproteinase 32 99.64 Very High Very High Very High
diclofenac 8 99.52 Very High Very High Very High
dexamethasone 9 99.36 Very High Very High Very High
nalbuphine 1 96.28 Very High Very High Very High
methotrexate 55 89.96 High High
Action potential 27 88.96 High High
antagonist 15 83.76 Quite High
Inflammation 67 80.08 Quite High
fibrosis 63 78.32 Quite High
Disease Link Frequency Relevance Heat
Adhesions 9 100.00 Very High Very High Very High
Hypoxia 38 99.98 Very High Very High Very High
Diabetes Mellitus 229 99.84 Very High Very High Very High
Stress 80 99.76 Very High Very High Very High
Disseminated Intravascular Coagulation 6 99.52 Very High Very High Very High
Hypertension 18 93.12 High High
Anastomotic Leak 4 91.00 High High
Intervertebral Disk Degeneration 117 90.64 High High
Acute Myocarditis 30 89.36 High High
Diabetic Cardiomyopathies 39 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensory nerve ablation strikingly exacerbated early intestinal radiation toxicity (loss of mucosal surface area, inflammation, intestinal wall thickening), but attenuated the development of chronic intestinal radiation fibrosis (collagen I accumulation and transforming growth factor beta immunoreactivity).
Positive_regulation (accumulation) of collagen I in thickening
1) Confidence 0.44 Published 2006 Journal Int. J. Radiat. Oncol. Biol. Phys. Section Body Doc Link 16580503 Disease Relevance 0 Pain Relevance 0
In the posterosuperior region, which is mainly subjected to compressive forces, a strong reaction for type II collagen was observed in the cartilaginous layer (maturative and hypertrophic cell layers), and a rather weak reaction was observed for type I collagen in the precartilaginous and cartilaginous layers, compared with the reactions in other peripheral regions.
Positive_regulation (observed) of type I collagen
2) Confidence 0.40 Published 1996 Journal Arch. Oral Biol. Section Abstract Doc Link 9022924 Disease Relevance 0.14 Pain Relevance 0.07
Parallel to the cell infiltration, an upregulation of messenger RNA-encoding collagen type I and transforming growth factor beta1 could be shown.
Positive_regulation (upregulation) of collagen type I
3) Confidence 0.37 Published 1997 Journal Gastroenterology Section Body Doc Link 9136846 Disease Relevance 0.07 Pain Relevance 0
Morphine enhanced the accumulation of collagen type I in a dose-dependent manner and also increased (p < 0.001) the accumulation of collagen type III at a high concentration (control, 1,291+/-55.8 vs. morphine, 10(-4) M, 2,697.6+/-257.8 ng/microg protein).
Positive_regulation (accumulation) of collagen type I associated with morphine
4) Confidence 0.34 Published 1997 Journal Nephron Section Abstract Doc Link 9346391 Disease Relevance 0.15 Pain Relevance 1.23
Amlodipine, but not nifedipine, prevented an increase in the relative amount of V3 myosin heavy chain isoform and suppressed an increase in mRNA levels of beta-myosin heavy chain, skeletal alpha-actin, and type 1 collagen.
Positive_regulation (increase) of type 1 collagen
5) Confidence 0.21 Published 1998 Journal Hypertension Section Abstract Doc Link 9449387 Disease Relevance 0.29 Pain Relevance 0.14
Instead, our data indicate that the contractile function is compromised by reduced and disrupted F-actin in conjunction with the increased type I collagen.
Positive_regulation (increased) of type I collagen
6) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.44 Pain Relevance 0
RESULTS: High glucose concentrations significantly increased PSC proliferation, alpha-SMA expression, and collagen type I production in PSCs.
Positive_regulation (increased) of collagen type I in PSCs
7) Confidence 0.20 Published 2007 Journal Pancreas Section Body Doc Link 17414061 Disease Relevance 0.16 Pain Relevance 0
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Positive_regulation (increase) of COLIA1
8) Confidence 0.19 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.75 Pain Relevance 0
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Positive_regulation (increase) of COLIA1
9) Confidence 0.19 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.70 Pain Relevance 0
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Positive_regulation (increase) of COLIA1
10) Confidence 0.19 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.69 Pain Relevance 0
Accordingly, we found in our array analysis the upregulation of collagen type I and IV in immunized rat hearts.
Positive_regulation (upregulation) of collagen type I in hearts
11) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.36 Pain Relevance 0.07
Immunohistochemistry of LV free wall showed that type I collagen was increased in diabetic rats (diabetic 7.1 ± 0.1%, control 12.7 ± 0.1%; P < 0.01), and F-actin content reduced (diabetic 56.9 ± 0.6%; control 61.7 ± 0.4%; P < 0.0001) with a disrupted structure.
Positive_regulation (increased) of type I collagen associated with diabetes mellitus
12) Confidence 0.14 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494698 Disease Relevance 1.01 Pain Relevance 0.08
Diabetic hearts showed increased type I collagen per endocardial cross-sectional area (diabetic 7.1 ± 0.1% of area, control 6.2 ± 0.2% of area; P < 0.01) without significant change in type III collagen (diabetic 6.5 ± 0.1% of area, control: 6.2 ± 0.1% of area).
Positive_regulation (increased) of type I collagen in hearts associated with diabetes mellitus
13) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 1.21 Pain Relevance 0
Further, the collagen type I maintaining tissue structure and collagen type IV, a component of basal lamina that allows interaction with integrins and favors cell adhesion, were increased expressed.
Positive_regulation (increased) of collagen type I in basal lamina associated with adhesions
14) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.41 Pain Relevance 0.04
Quantitative analysis also clearly demonstrated an markedly increase in the size of the area staining for collagen, especially for type I, as well as an increased collagen type I/III ratio in the EAM60 group compared to the control group.
Positive_regulation (increased) of collagen type I
15) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 0.41 Pain Relevance 0.38
Densitometry analysis further confirmed an increase in type-I collagen since the ratio of type-I to type-III collagen was significantly increased in tissues from ambulatory animals treated with IGF-I (p = 0.0129) and in unloaded tissues from GH+IGF-I treated animals (p = 0.0131), with a trend of increased levels in ambulatory GH+IGF and HU + IGF tissues (Fig. 7).
Positive_regulation (increase) of type-I collagen
16) Confidence 0.06 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.07 Pain Relevance 0.03
Because collagenase activity affects accumulation of type I collagen, we evaluated the effects of NIM811 on collagenase activity in TWNT-4 cells.
Positive_regulation (accumulation) of type I collagen
17) Confidence 0.05 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.15 Pain Relevance 0.07
The effect of intrastriatal administration of glutaric acid (GTR), a metabolite that accumulates in glutaric acidemia type I (GA-I), on the behavior of adult male rats was investigated.
Positive_regulation (accumulates) of type I
18) Confidence 0.04 Published 1998 Journal Brain Res. Section Abstract Doc Link 9748501 Disease Relevance 0.14 Pain Relevance 0.06
Effects of NIM811 on type I collagen accumulation, matrix metalloproteinase 1 and tissue inhibitor of metalloproteinase-1 production and collagenase activity
Positive_regulation (accumulation) of type I collagen associated with metalloproteinase
19) Confidence 0.04 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.17 Pain Relevance 0.10
There was no effect on collagen I mRNA under the normoxic conditions, but there was a decrease in collogen III; under the stress of hypoxia collagen I mRNA levels were increased by both ligands (Figure 6).
Positive_regulation (increased) of collagen I mRNA associated with stress and hypoxia
20) Confidence 0.04 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.76 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox