INT67737

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.08
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pam) lyase activity (Pam)
Anatomy Link Frequency
paw 1
Pam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 15 98.44 Very High Very High Very High
Neuropeptide 15 97.36 Very High Very High Very High
Pain 2 89.28 High High
Calcitonin gene-related peptide 5 89.04 High High
Inflammation 15 86.40 High High
Inflammatory response 5 85.44 High High
Analgesic 15 75.00 Quite High
sodium channel 25 17.96 Low Low
Action potential 14 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypopituitarism 33 100.00 Very High Very High Very High
Pressure And Volume Under Development 11 99.34 Very High Very High Very High
INFLAMMATION 25 98.48 Very High Very High Very High
Hypokalemic Periodic Paralysis 6 98.44 Very High Very High Very High
Hyperkalemic Periodic Paralysis 5 97.04 Very High Very High Very High
Myotonic Disorders 13 95.92 Very High Very High Very High
Disease 10 90.84 High High
Congenital Myasthenic Syndromes 6 80.24 Quite High
Paralysis 8 76.92 Quite High
Muscle Weakness 2 76.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the continuous administration of PBA to animals over a 7-day period using osmotic pumps not only inhibited hind paw swelling induced by carrageenan but also inhibited serum PAM activity and reduced tissue levels of substance P in hind paws.
Negative_regulation (inhibited) of serum PAM in paw associated with pressure and volume under development and substance p
1) Confidence 0.51 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023299 Disease Relevance 0.59 Pain Relevance 0.47
These results demonstrate for the first time a correlation between the antiinflammatory activity produced by an inhibitor of peptide amidation with its ability to inhibit serum PAM activity and lower endogenous tissue levels of substance P.
Negative_regulation (inhibit) of serum PAM associated with inflammation and substance p
2) Confidence 0.51 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023299 Disease Relevance 0.58 Pain Relevance 0.53
4-Phenyl-3-butenoic acid (PBA) has been shown in vitro to be a turnover-dependent inactivator of peptidylglycine alpha-monooxygenase (PAM), the rate-limiting enzyme involved in the formation of amidated neuropeptides from their glycine-extended precursors.
Negative_regulation (inactivator) of PAM associated with neuropeptide
3) Confidence 0.43 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023299 Disease Relevance 0.25 Pain Relevance 0.33
In the studies reported herein, we have shown that PBA produces a dose-dependent (50-500 mg/kg s.c.) inhibition of serum PAM activity in normal rats without affecting peptidylamidoglycolate lyase activity.
Negative_regulation (inhibition) of serum PAM
4) Confidence 0.38 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023299 Disease Relevance 0.36 Pain Relevance 0.38
4-Phenyl-3-butenoic acid (PBA) has been shown in vitro to be a turnover-dependent inactivator of peptidylglycine alpha-monooxygenase (PAM), the rate-limiting enzyme involved in the formation of amidated neuropeptides from their glycine-extended precursors.
Negative_regulation (inactivator) of alpha-monooxygenase associated with neuropeptide
5) Confidence 0.37 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023299 Disease Relevance 0.25 Pain Relevance 0.33
The prevalence of PAM is estimated at ?
Negative_regulation (prevalence) of PAM associated with hypopituitarism
6) Confidence 0.04 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883924 Disease Relevance 2.05 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox