INT67822

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 19.05
Pain Relevance 7.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SERPINH1) response to stress (SERPINH1)
Anatomy Link Frequency
bowel 2
blood 1
erythrocyte 1
connective tissue 1
SERPINH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 467 100.00 Very High Very High Very High
Inflammation 96 100.00 Very High Very High Very High
psoriasis 74 99.80 Very High Very High Very High
spinal inflammation 38 99.76 Very High Very High Very High
Osteoarthritis 9 99.72 Very High Very High Very High
Adalimumab 52 99.56 Very High Very High Very High
Etanercept 44 99.16 Very High Very High Very High
cytokine 38 98.92 Very High Very High Very High
metalloproteinase 30 96.76 Very High Very High Very High
Inflammatory response 4 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 425 100.00 Very High Very High Very High
Disease 119 100.00 Very High Very High Very High
Infection 106 100.00 Very High Very High Very High
Arthritis 51 100.00 Very High Very High Very High
Cancer 22 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Psoriasis 96 99.80 Very High Very High Very High
Reprotox - General 1 10 99.80 Very High Very High Very High
Low Back Pain 42 99.76 Very High Very High Very High
Inflammatory Bowel Disease 2 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the OA sera clearly cross-reacted with recombinant HSP47.
HSP47 Binding (cross-reacted) of associated with osteoarthritis
1) Confidence 0.36 Published 1999 Journal Arch. Oral Biol. Section Abstract Doc Link 10391498 Disease Relevance 1.35 Pain Relevance 0.71
Spontaneous preterm deliveries were clearly associated with threatened preterm labour, PPROM and vaginal bleeding.
PPROM Binding (associated) of associated with reprotox - general 1
2) Confidence 0.30 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2877057 Disease Relevance 0.93 Pain Relevance 0
In order to determine the cause of the disease, depending on the patient's history, complete blood cell count, blood cultures, cryoglobulins, serum protein electrophoresis, rheumatoid factor, antinuclear antibody, and autoantibodies to neutrophilic cytoplasmic antigens and complement should be checked.
rheumatoid factor Spec (determine) Binding (determine) of in blood associated with disease
3) Confidence 0.23 Published 2001 Journal Scand. J. Rheumatol. Section Abstract Doc Link 11846048 Disease Relevance 1.37 Pain Relevance 0.13
However, several reports have demonstrated that PPROM is associated with matrix degrading enzymes, such as, plasminogen activators (PAs) and matrix metalloproteinases (MMPs) (22-24).
PPROM Binding (associated) of associated with metalloproteinase
4) Confidence 0.17 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526504 Disease Relevance 0.48 Pain Relevance 0.17
Preterm pre-labor rupture of membranes has been associated with intrauterine infection, tobacco use, abruption, multiple gestations, previous PPROM, previous cervical surgery or laceration, a short cervix by ultrasound, genetic connective tissue disorders, and vitamin C deficiency.
PPROM Binding (associated) of in connective tissue associated with lacerations, rupture, mixed connective tissue disorder and infection
5) Confidence 0.12 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 1.34 Pain Relevance 0.19
Also other non-protein markers are associated with PPROM such as lactate [173,179,180], urea [181] and creatinine [181-183].
PPROM Binding (associated) of
6) Confidence 0.10 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.57 Pain Relevance 0
Until now, management of PPROM between 34 and 37 weeks' gestation varies in the Netherlands.
PPROM Binding (management) of
7) Confidence 0.08 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1934382 Disease Relevance 0.69 Pain Relevance 0
This subsequent evaluation includes the use of such laboratory tests as complete blood cell count with differential count, Chem 20 health profile, erythrocyte sedimentation rate, and an arthritic panel (assessment of rheumatoid factor, antinuclear antibody, C-reactive protein).
rheumatoid factor Binding (assessment) of in erythrocyte associated with arthritis
8) Confidence 0.03 Published 1997 Journal J Am Osteopath Assoc Section Abstract Doc Link 9029877 Disease Relevance 0.84 Pain Relevance 0.63
However, cholinesterase does not have the structural features suitable for binding with arsenic.
arsenic Binding (binding) of
9) Confidence 0.02 Published 2010 Journal Environ Health Section Body Doc Link PMC2911418 Disease Relevance 0.12 Pain Relevance 0.03
Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study

Studies on autoantibody production in patients treated with tumor necrosis factor-?

rheumatoid factor Binding (associated) of associated with necrosis, cancer and adalimumab
10) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1526573 Disease Relevance 0.51 Pain Relevance 0.35
As occurrence of multiple pharmaceuticals in water at low concentrations have been reported [1,4,13,23,33], consideration of their interactions in QPhRA becomes important as it constitutes an important uncertainty [3,8,11].
QPhRA Binding (interactions) of
11) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2996217 Disease Relevance 0.09 Pain Relevance 0
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis and psoriasis.
arthritis Binding (association) of associated with seronegative spondarthritis, psoriasis, inflammation, arthropathy and arthritis
12) Confidence 0.01 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.09 Pain Relevance 0.41
Psoriatic arthritis: Pathogenesis and novel immunomodulatory approaches to treatment

Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis and psoriasis.

arthritis Binding (association) of associated with seronegative spondarthritis, psoriasis, inflammation, arthropathy and arthritis
13) Confidence 0.01 Published 2005 Journal J Immune Based Ther Vaccines Section Title Doc Link PMC1208938 Disease Relevance 1.42 Pain Relevance 0.57
It is commonly classified as a subtype of the spondyloarthropathy (SpA) concept, together with ankylosing spondylitis (AS), reactive arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthropathy (USpA) [1].
arthritis Binding (associated) of in bowel associated with seronegative spondarthritis, spinal inflammation, inflammation and arthritis
14) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.89 Pain Relevance 0.88
It is commonly classified as a subtype of the spondyloarthropathy (SpA) concept, together with ankylosing spondylitis (AS), reactive arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthropathy (USpA) [1].
arthritis Binding (associated) of in bowel associated with seronegative spondarthritis, spinal inflammation, inflammation and arthritis
15) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.89 Pain Relevance 0.88
The anticyclic citrullinated peptide (anti-CCP) antibody and rheumatoid factor also significantly declined.
rheumatoid factor Binding (declined) of
16) Confidence 0.00 Published 2006 Journal Mod Rheumatol Section Abstract Doc Link 16906369 Disease Relevance 2.34 Pain Relevance 0.72
The treatment team then chose etanercept, a synthetic fusion protein therapy that binds with tumor necrosis factor (TNF)-alpha, to interrupt reactive inflammatory arthritis.
arthritis Binding (binds) of associated with necrosis, inflammation, cancer, etanercept and arthritis
17) Confidence 0.00 Published 2009 Journal Aust Dent J Section Abstract Doc Link 19473159 Disease Relevance 1.49 Pain Relevance 1.02
Association between the interleukin-1 family gene cluster and psoriatic arthritis.
arthritis Binding (Association) of associated with seronegative spondarthritis and arthritis
18) Confidence 0.00 Published 2006 Journal Arthritis Rheum. Section Title Doc Link 16918024 Disease Relevance 0.64 Pain Relevance 0.55

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