INT67849

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.83
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SKP1) nucleoplasm (SKP1)
Anatomy Link Frequency
reservoir 2
inner ear 2
bars 1
SKP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 264 99.84 Very High Very High Very High
Pain 6 98.74 Very High Very High Very High
psoriasis 63 95.44 Very High Very High Very High
rheumatoid arthritis 30 75.88 Quite High
Inflammation 60 74.40 Quite High
cytokine 36 71.20 Quite High
Infliximab 3 65.76 Quite High
Central nervous system 3 46.20 Quite Low
chemokine 6 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 234 99.84 Very High Very High Very High
Pain 3 98.74 Very High Very High Very High
Hypercalcemia 18 98.40 Very High Very High Very High
Arthritis 30 95.96 Very High Very High Very High
Psoriasis 66 95.44 Very High Very High Very High
Disease 21 88.40 High High
Rheumatoid Arthritis 30 75.88 Quite High
INFLAMMATION 39 74.40 Quite High
Iron Overload 6 42.24 Quite Low
Wound Healing 3 37.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the sequence in the 3'-UTR of CM1, a PCR primer pain was synthesized and used to confirm that a human homologue of Ocp2-rs2, designated OCP2 and expressed in the developing human inner ear, is localized to 5q22-5q35.2.
Gene_expression (expressed) of OCP2 in inner ear associated with pain
1) Confidence 0.78 Published 1997 Journal Gene Section Abstract Doc Link 9031623 Disease Relevance 0.10 Pain Relevance 0.10
Based on the sequence in the 3'-UTR of CM1, a PCR primer pain was synthesized and used to confirm that a human homologue of Ocp2-rs2, designated OCP2 and expressed in the developing human inner ear, is localized to 5q22-5q35.2.
Gene_expression (expressed) of Ocp2 in inner ear associated with pain
2) Confidence 0.78 Published 1997 Journal Gene Section Abstract Doc Link 9031623 Disease Relevance 0.10 Pain Relevance 0.10
Other OCP2-like sequences located on chromosomes 4p16.2-4p14, 7pter-q22 and 12p13-12qter (but not the chromosome 10 OCP2-like sequence) will PCR amplify the expected size product at a lower annealing temperature using the OCP2 3'-UTR PCR primers indicating that there may be a human OCP2 gene family.
Gene_expression (located) of OCP2-like
3) Confidence 0.67 Published 1997 Journal Gene Section Abstract Doc Link 9031623 Disease Relevance 0.09 Pain Relevance 0.09
These studies indicate that the major reservoir of OCP in PsA is CD16+ cells, a finding that may catalyze the development of susceptibility biomarkers for arthritis in Ps patients and a treatment response marker in PsA patients with erosive arthritis.
Gene_expression (reservoir) of OCP in reservoir associated with psoriasis and arthritis
4) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.22 Pain Relevance 0.57
CD16+ cells are the major reservoir of OCP in PsA patients
Gene_expression (reservoir) of OCP in reservoir associated with arthritis
5) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.49 Pain Relevance 0.25
Although CD16+ cells were the major reservoir of OCP in most PsA patients (Figure 4(b), subject numbers 5 to 8, orange bars), it is noteworthy that CD16int cells, instead of CD16+, were the source of OCP in one of the PsA subjects (Figure 4(b), subject number 4, turquoise bar).
Gene_expression (source) of OCP in bars associated with arthritis
6) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.83 Pain Relevance 0.37

General Comments

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