INT67860

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.49
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ETF1) RNA binding (ETF1) translation (ETF1)
cytoplasm (ETF1)
Anatomy Link Frequency
reticulum 2
neuron 1
ETF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 15 96.84 Very High Very High Very High
Morphine 3 94.32 High High
opioid receptor 1 90.40 High High
narcan 1 89.36 High High
bradykinin 2 74.52 Quite High
opiate 1 74.44 Quite High
adenocard 58 24.56 Low Low
antagonist 4 18.40 Low Low
GABA receptor 2 17.96 Low Low
Migraine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 29 95.86 Very High Very High Very High
Disease 18 70.88 Quite High
Apoptosis 8 58.00 Quite High
Neurodegenerative Disease 10 51.92 Quite High
Motor Neuron Diseases 37 50.00 Quite Low
Infection 17 45.84 Quite Low
Diabetes Mellitus 4 39.36 Quite Low
Cancer 3 38.96 Quite Low
Asthma 2 38.64 Quite Low
Increased Venous Pressure Under Development 24 38.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In colonic strips incubated with [3H]-choline, fedotozine (10(-5)-10(-4) M) induced an erratic decrease of acetylcholine-release induced by electric stimulation.
Positive_regulation (induced) of acetylcholine-release
1) Confidence 0.23 Published 1996 Journal Ital J Gastroenterol Section Abstract Doc Link 9032586 Disease Relevance 0.07 Pain Relevance 0.46
This mechanism is compatible with the general characteristics of the calcium-induced calcium release (CICR) [27, 29, 49], in which a minimal quantity of Ca2+ is required in the cytoplasm: not enough to activate the eNOS but enough to stimulate the release of more Ca2+ from the reticulum, increasing the iCa2+.
Positive_regulation (stimulate) of release in reticulum
2) Confidence 0.02 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0 Pain Relevance 0.03
Caffeine stimulates the release of Ca2+ from the reticulum, increasing its concentration in the cytoplasm (iCa2+), forming a complex with calmodulin which favors the activation of eNOS.
Positive_regulation (stimulates) of release in reticulum
3) Confidence 0.02 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0 Pain Relevance 0.04
After stimulation of human neuroblastoma and macrophage co-cultures with the TLR2 agonist Pam3CSK4 for a period of 72 hours the release of neuron-specific enolase (NSE) was measured in the culture supernatants and expressed as per cent of the NSE release induced by cell lysis.
Positive_regulation (induced) of release in neuron associated with neuroblastoma and agonist
4) Confidence 0.01 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.42 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox