INT67862

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Context Info
Confidence 0.29
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.45
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ETF1) RNA binding (ETF1) translation (ETF1)
cytoplasm (ETF1)
ETF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 2 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Neurotransmitter 1 100.00 Very High Very High Very High
adenocard 29 99.32 Very High Very High Very High
Morphine 3 94.80 High High
Abstinence syndrome 2 91.04 High High
narcan 1 89.84 High High
opioid receptor 1 89.76 High High
Migraine 6 86.60 High High
Disease Link Frequency Relevance Heat
Cancer 2 100.00 Very High Very High Very High
Migraine Disorders 4 97.12 Very High Very High Very High
Syndrome 2 91.04 High High
Headache 9 86.60 High High
Stress 4 83.04 Quite High
Prostate Cancer 1 75.00 Quite High
Pain 2 73.84 Quite High
Disease 6 71.36 Quite High
Increased Venous Pressure Under Development 12 57.52 Quite High
Anxiety Disorder 1 22.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In colonic strips incubated with [3H]-choline, fedotozine (10(-5)-10(-4) M) induced an erratic decrease of acetylcholine-release induced by electric stimulation.
Negative_regulation (decrease) of acetylcholine-release
1) Confidence 0.29 Published 1996 Journal Ital J Gastroenterol Section Abstract Doc Link 9032586 Disease Relevance 0.07 Pain Relevance 0.46
However, inhibition of COX-2 pathway alone did not seem sufficient to inhibit cancer cell proliferation, and NO-release in a time-dependent manner strongly contributes to this activity.
Negative_regulation (inhibit) of NO-release associated with cancer
2) Confidence 0.10 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 18667313 Disease Relevance 0.17 Pain Relevance 0.07
The mechanism by which this occurs is a blocking of the adenosine receptors; when there is an excessive release of adenosine there is a response in which the release of neurotransmitter molecules, such as serotonin, noradrenaline, acetylcholine, and dopamine, is inhibited, causing an imbalance that can be seen in the symptoms associated with migraines [72]
Negative_regulation (inhibited) of release associated with dopamine, neurotransmitter, adenocard, noradrenaline, migraine disorders and serotonin
3) Confidence 0.01 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 1.20 Pain Relevance 1.37

General Comments

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