INT67869

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.67
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
blood 1
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 9 99.20 Very High Very High Very High
cytokine 1 97.96 Very High Very High Very High
Paracetamol 8 96.48 Very High Very High Very High
Chronic pancreatitis 1 76.76 Quite High
opiate 1 74.36 Quite High
Opioid 1 70.68 Quite High
aspirin 3 50.00 Quite Low
qutenza 1 10.00 Low Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 90.20 High High
Cancer 1 89.84 High High
INFLAMMATION 1 77.60 Quite High
Pancreatitis 2 76.76 Quite High
Apoptosis 2 75.00 Quite High
Injury 2 75.00 Quite High
Stress 1 74.80 Quite High
Body Weight 1 57.16 Quite High
Hepatotoxicity 1 48.56 Quite Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative mRNA levels for the antioxidant enzymes CuZnSOD, MnSOD, CAT and Gpx-1 were determined by reverse transcriptase polymerase chain reaction (RT-PCR) in groups where differences in activities between control and treated samples were observed.
Spec (determined) Transcription (levels) of Gpx-1
1) Confidence 0.68 Published 2006 Journal Biogerontology Section Abstract Doc Link 16518720 Disease Relevance 0 Pain Relevance 0.90
The impact of these compounds on mRNA expression of GPX, TNF-alpha, and MCP-1 indicated that these compounds could act at a transcription level.
Transcription (expression) of GPX
2) Confidence 0.40 Published 2009 Journal J. Food Sci. Section Abstract Doc Link 19799668 Disease Relevance 0.44 Pain Relevance 0.58
TGF-beta1 suppressed mRNA expression as well as reduced the activities of catalase and GPx.
Transcription (expression) of GPx
3) Confidence 0.10 Published 1997 Journal Free Radic. Biol. Med. Section Abstract Doc Link 9034240 Disease Relevance 0.15 Pain Relevance 0.08
METHODS: Determinations were made of gastric mucosal injury, mucosal gastric blood flow, mucosal mRNA expression of glutathione peroxidase (GPx), zinc copper superoxide dismutase (SOD) and heat shock protein (HSP70) by RT-PCR and protein expression for HSP70 by Western blotting.
Transcription (expression) of GPx in blood
4) Confidence 0.02 Published 2003 Journal Inflamm. Res. Section Body Doc Link 14504662 Disease Relevance 0.08 Pain Relevance 0

General Comments

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